Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small celllung cancer with brain metastases: A retrospective analysis of multicenter study (anatolian society ofmedical oncology)

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dc.contributor.authorElkiran, Emin Tamer
dc.date.accessioned2019-07-24T06:37:19Z
dc.date.available2019-07-24T06:37:19Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.en_US
dc.identifier.citationElkıran, ET. (2018). Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small celllung cancer with brain metastases: A retrospective analysis of multicenter study (anatolian society ofmedical oncology). Cilt:14 Sayı:3, 578-582 ss.en_US
dc.identifier.doi10.4103/0973-1482.176417en_US
dc.identifier.endpage582en_US
dc.identifier.issue3en_US
dc.identifier.startpage578en_US
dc.identifier.urihttps://hdl.handle.net/11616/12893
dc.identifier.volume14en_US
dc.language.isoenen_US
dc.publisherMedknow publıcatıons & medıa pvt ltd, b-9, kanara busıness centre, off lınk rd, ghaktopar-e, mumbaı, 400075, ındıaen_US
dc.relation.ispartofJournal of cancer research and therapeutıcsen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectTyrosıne Kınase Inhıbıtorsen_US
dc.subjectPhase-Iı-Trıalen_US
dc.subjectRadıcal Treatmenten_US
dc.subjectNever-Smokersen_US
dc.subjectSurvıvalen_US
dc.subjectAdenocarcınomaen_US
dc.subjectManagementen_US
dc.subjectTherapyen_US
dc.subjectRadıotherapyen_US
dc.subjectGefıtınıben_US
dc.titlePrognostic factors of patients who received chemotherapy after cranial irradiation for non-small celllung cancer with brain metastases: A retrospective analysis of multicenter study (anatolian society ofmedical oncology)en_US
dc.typeArticleen_US

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