Evaluation of the serum C-reactive protein-albumin ratio and its relationship with disease severity IN alopecia areata: A prospective case-control study

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dc.authoridKALAYCI, BULENT NURI/0000-0001-5838-8528
dc.authoridBalta, Ilknur/0000-0002-0909-589X
dc.authorwosidli, juqian/KII-7123-2024
dc.authorwosidKALAYCI, BÜLENT/HKF-3285-2023
dc.contributor.authorKalayci, Bulent Nuri
dc.contributor.authorBalta, Ilknur
dc.date.accessioned2024-08-04T20:58:46Z
dc.date.available2024-08-04T20:58:46Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Alopecia areata (AA) is an autoimmune and inflammatory disease characterized by localized or diffuse non-scarring hair loss. The serum C-reactive protein (CRP)/albumin ratio (CAR) is a novel inflammatory marker and a significant prognostic indicator in several diseases. Aim We aimed to explore CAR in AA patients and healthy controls and analyze the possible correlation between CAR and disease severity. Method The present study was conducted with 65 eligible AA patients and 65 age- and gender-matched healthy controls. Disease severity was analyzed based on the Severity of Alopecia Tool (SALT) score. The CAR score was calculated by dividing serum CRP by the albumin content in both patient and healthy control groups. Findings 56.9% of the patients were male and 43.1% were female, and the mean age was 31.93 +/- 9.67. The patient group' mean CAR level (0.42 +/- 0.3) was statistically higher than that of the healthy controls (0.07 +/- 0.04), (p < 0.05). There were positive correlations between disease severity, CAR (r = 0.65; p < 0.01), and CRP (r = 0.66; p < 0.01), while the correlation between disease severity and albumin was negative (r = -0.56; p < 0.01). In the receiver operating characteristic analysis conducted on disease severity, the area under the curve was 0.16 for albumin, 0.92 for CRP, and 0.95 for CAR. The optimum CAR for AA severity was 0.38 with 87% sensitivity and 92% specificity. Conclusion In the study, we determined that the CAR was higher in AA patients when compared to the control group, and the elevation was associated with disease severity. The present study findings demonstrated that alopecia areata was associated with systemic inflammation, and CAR is a useful inflammatory marker in AA patients.en_US
dc.identifier.doi10.1111/jocd.15460
dc.identifier.endpage7199en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue12en_US
dc.identifier.pmid36225083en_US
dc.identifier.startpage7194en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.15460
dc.identifier.urihttps://hdl.handle.net/11616/103151
dc.identifier.volume21en_US
dc.identifier.wosWOS:000878242900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalbuminen_US
dc.subjectalopecia areataen_US
dc.subjectC-reactive proteinen_US
dc.subjectC-reactive protein-albumin ratio (CAR)en_US
dc.subjectinflammatory markeren_US
dc.titleEvaluation of the serum C-reactive protein-albumin ratio and its relationship with disease severity IN alopecia areata: A prospective case-control studyen_US
dc.typeArticleen_US

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