Protective effect of Lycium barbarum on renal injury induced by acute pancreatitis in rats

Basit Öğe Kaydı
dc.contributor.authorDogan, Tugba
dc.contributor.authorBatcioglu, Kadir
dc.contributor.authorKustepe, Elif Kayhan
dc.contributor.authorUyumlu, Ayse Burcin
dc.contributor.authorYilmaztekin, Yakup
dc.date.accessioned2024-08-04T21:00:55Z
dc.date.available2024-08-04T21:00:55Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Lycium barbarum (LB) is a plant species that is well known in Chinese traditional medicine and is also considered a nutrient, belonging to the Solanaceae family, also called goji berry or wolfberry. Objectives: The aim of this study was to investigate the protective efficacy of LB, in kidney damage caused by acute pancreatitis (AP). Materials and Methods: In the study, we used 36 female Wistar albino rats (12 in each group) which were divided into three groups: Control, cerulein (100 mu g/kg b. wt. intraperitonally) and Cerulein + LB (6 mg/ml/day gastric gavage) group. Serum lipase, Interleukin (IL)-1, and IL-6 levels were measured. Superoxide dismutase, catalase (CAT), glutathione peroxidase enzyme activity assays and 8-hydroxy deoxyguanosine, malondialdehyde (MDA), and protein levels were measured in kidney tissue samples. In addition, histopathological analysis was performed in kidney tissue samples. Results: According to the findings, in the AP model created with Cerulein, administration of LB plant extract decreased oxidative stress and damage caused by AP in the kidney tissue and partially suppressed the inflammatory reactions in the tissue. Conclusion: According to the findings, in the AP model created with Cerulein, administration of LB extract decreased oxidative stress and in kidney damage caused by AP.en_US
dc.identifier.doi10.4103/pm.pm_516_21
dc.identifier.endpage159en_US
dc.identifier.issn0973-1296
dc.identifier.issn0976-4062
dc.identifier.issue77en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.4103/pm.pm_516_21
dc.identifier.urihttps://hdl.handle.net/11616/103939
dc.identifier.volume18en_US
dc.identifier.wosWOS:000789098400020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofPharmacognosy Magazineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectantioxidant enzymesen_US
dc.subjectkidney Injuryen_US
dc.subjectLycium barbarumen_US
dc.subjectoxidative stressen_US
dc.titleProtective effect of Lycium barbarum on renal injury induced by acute pancreatitis in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu