The evaluation and classification of drug-related problems by a clinical pharmacist in an internal diseases intensive care unit: A prospective cohort 7-month study

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dc.contributor.authorDurmus, Mefkuere
dc.contributor.authorGun, Zeynep Ulku
dc.contributor.authorBerktas, Haci Bayram
dc.date.accessioned2024-08-04T21:02:03Z
dc.date.available2024-08-04T21:02:03Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims: Drug -related problems can cause morbidity and mortality as well as increase health-care costs. Clinical pharmacists provide many benefits to healthcare systems by detecting, decreasing, and preventing drug -related problems. It was aimed to determine and classify drug -related problems and determine risk factors for drug -related problems. Methods: Drug -related problems were evaluated prospectively between August 16, 2021, and March 16, 2022, in 257 patients during their hospital stay who were hospitalized in the internal diseases intensive care unit and took at least one drug. Patients who were not administered any drug or who were younger than 18 were excluded from the study. The Pharmacetical Care Network Europe v.9 method was utilized to classify these problems. Clinical and demographic characteristics of patients with and without drug -related problems were compared by statistical analysis. Risk factors of drug -related problems were determined by logistic regression analysis. Results: At least one drug -related problem was detected in 157 of the 257 patients and a total of 399 drug -related problems were recorded. 399 recommendations were made, and 349 (87.5%) of these were accepted and 50 (12.5%) were not accepted. Drug selection (C1) was the most common cause of drug -related problems at 42.2%, and dose selection (C3) followed this by 41.5%. The results of regression analysis showed that atrial fibrillation (OR: 2.985, CI: 1.158-7.692), hematopoietic stem cell transplantation (OR: 3.883, CI: 1.256-11.999), antibacterial drugs (OR: 3.285, CI: 1.563-6.904), or polypharmacy (OR: 3.955, CI:1.207- 11.071) were risk factors of drug -related problems. Conclusion: The most common drug -related problem category was found as treatment safety and the causes of them were found as drug selection and dose selection. Clinicians should pay attention when prescribing new drugs to patients with atrial fibrillation and a history of hematopoietic stem cell transplantation. Furthermore, clinicians and clinical pharmacists should pay attention if polypharmacy and antibacterial drugs are present in medical therapies.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2024.1327194
dc.identifier.endpage11en_US
dc.identifier.issn2587-2087
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2024.1327194
dc.identifier.urihttps://hdl.handle.net/11616/104435
dc.identifier.volume54en_US
dc.identifier.wosWOS:001216536800010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClinical pharmacyen_US
dc.subjectdrug -related problemen_US
dc.subjectintensive care uniten_US
dc.titleThe evaluation and classification of drug-related problems by a clinical pharmacist in an internal diseases intensive care unit: A prospective cohort 7-month studyen_US
dc.typeArticleen_US

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