The role of digital rectal examination, biopsy Gleason sum and prostate-specific antigen in selecting patients who require pelvic lymph node dissections for prostate cancer

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dc.authoridKattan, Michael W/0000-0002-3840-4161;
dc.authorwosidKattan, Michael W/HZM-2315-2023
dc.authorwosidDILLIOGLUGIL, OZDAL/AAS-1697-2020
dc.contributor.authorRogers, E
dc.contributor.authorGurpinar, T
dc.contributor.authorDillioglugil, O
dc.contributor.authorKattan, MW
dc.contributor.authorGoad, JR
dc.contributor.authorScardino, PT
dc.contributor.authorGriffith, DP
dc.date.accessioned2024-08-04T21:02:12Z
dc.date.available2024-08-04T21:02:12Z
dc.date.issued1996
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective To examine the usefulness of clinical stage, tumour differentiation and prostate-specific antigen (PSA) level, alone and in combination, to predict regional nodal metastases in individual patients with localized prostate cancer. Patients and methods The usefulness of digital rectal examination (DRE), biopsy Gleason sum and PSA, alone and in combination, to predict nodal metastases in an individual patient was examined. The study included 689 patients who had laparoscopic or open pelvic lymph node dissection for clinical stage T1-3 prostate cancer. The Kruskal-Wallis test, Mantel-Haenszel test, chi-squared test and logistic regression were used for continuous, ordinal, categorical, and multivariate analysis, respectively. Results Of the 689 patients who underwent radical prostatectomy, 52 (8%) had nodal metastases. Although clinical stage, DRE, pre-operative PSA level and biopsy Gleason sum were significantly related in the univariate analysis, only pre-operative PSA level and biopsy Gleason sum were significant predictors of lymph node status in a multivariate analysis. However, based on a receiver operating characteristic curve, a model with satisfactory sensitivity and specificity could not be obtained. Conclusion Current estimations of primary prostate cancer biology using pre-operative PSA level, clinical stage and biopsy Gleason sum are not sufficiently sensitive to predict nodal metastases, and pelvic lymphadenectomy remains the definitive method of detection.en_US
dc.identifier.doi10.1046/j.1464-410X.1996.00117.x
dc.identifier.endpage425en_US
dc.identifier.issn0007-1331
dc.identifier.issue3en_US
dc.identifier.pmid8881954en_US
dc.identifier.startpage419en_US
dc.identifier.urihttps://doi.org/10.1046/j.1464-410X.1996.00117.x
dc.identifier.urihttps://hdl.handle.net/11616/104561
dc.identifier.volume78en_US
dc.identifier.wosWOS:A1996VF04700018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBritish Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectprostatic neoplasmsen_US
dc.subjectlymph node metastasesen_US
dc.subjectpre-operative stagingen_US
dc.titleThe role of digital rectal examination, biopsy Gleason sum and prostate-specific antigen in selecting patients who require pelvic lymph node dissections for prostate canceren_US
dc.typeArticleen_US

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