Neuro-ichthyotic syndromes: a case series
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MEDKNOW PUBLICATIONS & MEDIA PVT LTD, B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA
Erişim Hakkı
info:eu-repo/semantics/restrictedAccess
Özet
Background: The neuro-ichthyotic diseases are clinically and genetically heterogeneous. The purpose of this study was to evaluate the clinical and neuroradiological findings and to analyze mutation in 15 patients with neuro-ichthyotic diseases. Materials and Methods: We retrospectively analyzed the records of 15 patients with the diagnosis of neuro-ichthyotic diseases. Results: Eight female and seven male patients (age range 11 months-52 years) were investigated. There were eight patients with Sjogren-Larsson syndrome (SLS), five patients with multiple sulfatase deficiency (MSD), one patient with Chanarin-Dorfman's syndrome, and one patient with mental retardation, enteropathy, deafness, neuropathy, ichthyosis, and keratodermia (MEDNIK) syndrome. Parental consanguinity was found in all the patients except one. All patients had ichthyosis. Diagnosis was performed with genetic study. Conclusions: Because biochemical and clinical findings are variable, the diagnosis is difficult in most of the cases. Detailed skin and physical examinations are mandatory in these patients. Genetic tests are necessary for accurate diagnosis.
Açıklama
Anahtar Kelimeler
Multıple Sulfatase Defıcıency, Sjogren-Larsson-Syndrome, Chanarın-Dorfman-Syndrome, Copper-Metabolısm, Mednık Syndrome, Pathogenesıs, Defect
Kaynak
Journal of pedıatrıc neuroscıences
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
1
Künye
Güngör, S. (2018). Neuro-ichthyotic syndromes: a case series. Cilt:13 Sayı:1, 34-38 ss.
