Utility of blind forceps biopsy of the main carina and upper-lobe carina in patients with non-small cell lung cancer

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dc.authoridGunen, Hakan/0000-0001-6631-4457
dc.authorwosidGunen, Hakan/HKV-9202-2023
dc.contributor.authorGunen, H
dc.contributor.authorKizkin, O
dc.contributor.authorTahaoglu, C
dc.contributor.authorAktas, O
dc.date.accessioned2024-08-04T21:02:23Z
dc.date.available2024-08-04T21:02:23Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective: Preoperative detection of non-small cell lung cancer (NSCLC) metastasis to the main carina and upper-lobe carina can alter the operative approach, preclude further staging procedures, and save many patients from thoracotomy. This stum assessed whether bronchoscopic forceps biopsy of the normal-appearing main carina and upper-lobe carina (blind biopsy) ipsilateral to the primary NSCLC lesion improved the accuracy of cancer staging and helped guide the management of these patients. Patients and methods: A prospective study of 52 patients was carried out at the SSK Surveyypasa Center for Chest Disease and Cardiothoracic Surgery. Over a 6-month period, we bronchoscopically evaluated 52 consecutive NSCLC patients who were radiologically classified as operable. At least five blind forceps biopsy specimens were obtained from the main carina and/or upper-lobe carina during each patient's initial fiberoptic bronchoscopic examination. Biopsy specimens were collected from the main carina and upper-lobe carina in 51 and 17 patients, respectively. Initially, all patients were staged and evaluated for operability in standard fashion, without histologic assessment of the blind biopsy specimens. We then restaged the disease and reassessed the patients' operability in light of the biopsy findings. Results: Metastasis was histologically diagnosed in seven patients (13.7%) who underwent main carina biopsy and in four patients (23.5%) who underwent upper-lobe carina biopsy. Cancer-positive blind biopsy results changed the status of 25% (6 of 24) of patients from operable to inoperable, and changed the surgical approach in 11.1% (2 of 18) of patients who ultimately did undergo surgery. We found no statistical relationship between metastasis to either carina and tumor type, stage of disease, visibility of the tumor on fiberoptic bronchoscopy, primary tumor location, T status, or N status (p > 0.05). Conclusions: A blind forceps biopsy of the main carina and upper-lobe carina ipsilateral to the lesion site should be done routinely at initial bronchoscopic examination of all radiologically operable patients with suspected lung cancer. This type of screening can save a significant number of NSCLC patients from inappropriate or unnecessary thoracotomy and further staging procedures with their associated morbidity and risk.en_US
dc.identifier.doi10.1378/chest.119.2.632
dc.identifier.endpage637en_US
dc.identifier.issn0012-3692
dc.identifier.issn1931-3543
dc.identifier.issue2en_US
dc.identifier.pmid11171748en_US
dc.identifier.startpage632en_US
dc.identifier.urihttps://doi.org/10.1378/chest.119.2.632
dc.identifier.urihttps://hdl.handle.net/11616/104700
dc.identifier.volume119en_US
dc.identifier.wosWOS:000166977300049en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofChesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectblind biopsyen_US
dc.subjectcarinaen_US
dc.subjectfiberoptic bronchoscopyen_US
dc.subjectlung canceren_US
dc.titleUtility of blind forceps biopsy of the main carina and upper-lobe carina in patients with non-small cell lung canceren_US
dc.typeArticleen_US

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