Meropenem-Associated Acute Hepatocellular Liver Injury: A Rare Case Report

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dc.contributor.authorSalduz, Ekrem
dc.contributor.authorAvcu, Atakan
dc.contributor.authorKose, Adem
dc.contributor.authorYilmaz, Zeynep Burcin
dc.date.accessioned2026-04-04T13:30:41Z
dc.date.available2026-04-04T13:30:41Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractDrug-induced liver injury (DILI) is a serious and commonly encountered clinical complication, the diagnosis of which is usually established by exclusion. Antibiotics, particularly beta-lactam agents, are among the leading causes of DILI. Meropenem is a widely used broad-spectrum carbapenem antibiotic. This report presents a case of acute hepatocellular liver injury that developed within 24 hours after initiation of meropenem for the treatment of pneumonia in an 85-year-old patient. Viral hepatitis, autoimmune diseases, and other potential causes of liver injury were comprehensively excluded. In the presence of marked elevations in liver enzymes, meropenem was discontinued, after which the biochemical abnormalities were observed to resolve spontaneously without any specific treatment. Reports of meropenem-induced liver injury are rare in the literature; the rapid onset and reversibility observed in this case underscore the importance of drug discontinuation in management. In clinical practice, awareness of the risk of hepatotoxicity associated with meropenem use and adoption of a multidisciplinary approach in similar cases are of great importance.
dc.identifier.doi10.5578/flora.2026011492
dc.identifier.endpage134
dc.identifier.issn1300-932X
dc.identifier.issn2602-2842
dc.identifier.issue1
dc.identifier.startpage130
dc.identifier.urihttps://doi.org/10.5578/flora.2026011492
dc.identifier.urihttps://hdl.handle.net/11616/108306
dc.identifier.volume31
dc.identifier.wosWOS:001721010800016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherBilimsel Tip Yayinevi
dc.relation.ispartofFlora Infeksiyon Hastaliklari Ve Klinik Mikrobiyoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectDrug-induced liver injury
dc.subjectHepatotoxicity
dc.subjectMeropenem
dc.titleMeropenem-Associated Acute Hepatocellular Liver Injury: A Rare Case Report
dc.typeArticle

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