Evaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel method

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dc.authoridCure, Medine Cumhur/0000-0001-9253-6459
dc.authoridCüre, Erkan/0000-0001-7807-135X
dc.authoridAydogan Baykara, Rabia/0000-0003-0542-266X
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authorwosidCure, Medine Cumhur/A-1089-2018
dc.authorwosidCüre, Erkan/W-4922-2017
dc.authorwosiddoğan, erdal/ABI-7249-2020
dc.authorwosidAydogan Baykara, Rabia/ACI-5046-2022
dc.authorwosidEREL, Ozcan/U-1008-2019
dc.contributor.authorBaykara, Rabia Aydogan
dc.contributor.authorTuzcu, Ayca
dc.contributor.authorOmma, Ahmet
dc.contributor.authorAcet, Gunseli Karaca
dc.contributor.authorDogan, Erdal
dc.contributor.authorAydin, Almila
dc.contributor.authorCure, Medine Cumhur
dc.date.accessioned2024-08-04T20:58:45Z
dc.date.available2024-08-04T20:58:45Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Increased reactive oxygen species may play an important role in Ankylosing spondylitis (AS) etiopathogenesis. The thiol group is a very potent antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with AS by evaluating thiol/disulfide homeostasis. METHODS: In this study, a total of 66 AS patients (27 male, 39 female) and 66 healthy controls (21 male, 45 female) were enrolled. Recently, a novel method for the thiol measurement was found. Thiol and disulfide values were measured by the novel methods. RESULTS: Native thiol (NT) (p<0.001) and native thiol/total thiol (NTT) (p<0.001) levels of AS patients were significantly lower compared to the values of the healthy group. However, disulfide (p<0.001), disulfide/native thiol (DNT) (p<0.001) and disulfide/total thiol (DTT) levels of AS patients were a strongly higher control group. A negative correlation was found between BASFI and NTT. Also, a negative correlation was found between BASDAI and NT, NTT levels. A positive correlation was found between BASFI and disulfide, DNT and DTT levels. A positive correlation was found between BASFI and disulfide, DNT and DTT levels. CONCLUSION: The findings revealed that thiol-disulfide homeostasis deteriorated in patients with AS in favor of disulfide amounts. Thiol-disulfide homeostasis can play roles in the etiology and severity of AS.en_US
dc.identifier.doi10.14744/nci.2018.37132
dc.identifier.endpage354en_US
dc.identifier.issn2148-4902
dc.identifier.issue4en_US
dc.identifier.pmid31909379en_US
dc.identifier.startpage348en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2018.37132
dc.identifier.urihttps://hdl.handle.net/11616/103136
dc.identifier.volume6en_US
dc.identifier.wosWOS:000500484500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectthiolen_US
dc.subjectdisulfideen_US
dc.subjectthiol/disulfide homeostasisen_US
dc.subjectoxidative stressen_US
dc.titleEvaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel methoden_US
dc.typeArticleen_US

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