CHANGES IN TYROSINE HYDROXYLASE ACTIVITY, ADRENOMEDULLIN (ADM) AND TOTAL RNA LEVELS BY TREATMENT OF ORGANOSELENIUM COMPOUNDS IN RAT HYPOTHALAMUS EXPOSED TO 7,12-DIMETHYLBENZANTHRACENE (DMBA)

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dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorGok, Yetkin
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:57:21Z
dc.date.available2024-08-04T20:57:21Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of synthetic organoselenium compounds (Se I and Se II) on the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis as well as adrenomedullin (ADM) and total RNA levels were determined in the hypothalamus of adult rats exposed to DMBA (7,12-dimethylbenz[a]anthracene). DMBA, an organic environmental pollutant, is a polycyclic aromatic hydrocarbon that can induce a range of toxic effects and stress in rats. Selenium is an essential trace element, which interacts with antioxidants, and has anticancer and antihypertensive properties. TH is an aromatic amino acid hydroxylase whose activity is elevated in response to a range of stress inducers. TH activity is normally regulated by negative feedback in catecholamine biosynthesis. ADM is an abundantly present peptide in a broad range of normal tissues including adrenal medulla, lungs, kidneys and brain. Plasma ADM levels are elevated in a number of diseases including essential hyptertension and chronic renal failure. The antioxidant properties of ADM offer protection against organ damage induced by high blood pressure, ischemia and aging. DMBA treatment increased the TH activity and ADM level in the hypothalamus. These increases were found to be inhibited by Se I and Se II treatments. These studies demonstrate that synthetic organoselenium compounds can suppress DMBA-induced stress-related changes in the rat hypothalamus. Therefore, the antioxidant and antihypertensive effects of Se I and Se II may have important effects in the maintainance of homeostasis.en_US
dc.description.sponsorshipInonu University [BAP 2005/60]en_US
dc.description.sponsorshipInonu University Research Fund (BAP 2005/60) is gratefully acknowledged for support of this work.en_US
dc.identifier.endpage668en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4Aen_US
dc.identifier.startpage664en_US
dc.identifier.urihttps://hdl.handle.net/11616/102557
dc.identifier.volume19en_US
dc.identifier.wosWOS:000279807100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTyrosine hydroxylaseen_US
dc.subjectadrenomedullinen_US
dc.subjecthypothalamusen_US
dc.subjectsynthetic organoselenium compoundsen_US
dc.subjectDMBAen_US
dc.titleCHANGES IN TYROSINE HYDROXYLASE ACTIVITY, ADRENOMEDULLIN (ADM) AND TOTAL RNA LEVELS BY TREATMENT OF ORGANOSELENIUM COMPOUNDS IN RAT HYPOTHALAMUS EXPOSED TO 7,12-DIMETHYLBENZANTHRACENE (DMBA)en_US
dc.typeArticleen_US

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