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Gönderi tarihi için Makale Koleksiyonu listeleme

Gönderi tarihi için Makale Koleksiyonu listeleme

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  • The effect of melatonin on acetylsalicylic acid induced kidney and testis damage 
    Altıntaş, Ramazan; Polat, Alaadin; Parlakpınar, Hakan; Vardı, Nigar; Beytur, Ali; Oğuz, Fatih; Sağır, Mustafa; Yıldız, Azibe; Duran, Zeynep Rümeysa (Human & Experimental Toxicology, 2014)
    The aim of this study was to evaluate the acute effect of high-dose acetylsalicylic acid (ASA) on kidney and testis, and the potential protective and therapeutic effects of melatonin on ASA-related pathology. A total of ...
  • The protective effects of apocynin on kidney damage caused by renal ischemia reperfusion 
    Altıntaş, Ramazan; Polat, Alaadin; Vardı, Nigar; Beytur, Ali; Yıldız, Azibe; Sağır, Mustafa; Parlakpınar, Hakan; Oğuz, Fatih (Journal of Endourology, 2013)
    Purpose: This experimental study was designed to explore the protective effect of apocynin, the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. Methods: Thirty-two rats ...
  • Protective effects of melatonin and d glucan againstliver injury in rats a comparative study 
    Aydoğan, Mustafa Said; Erdoğan, Mehmet Ali; Polat, Alaadin; Yücel, Aytaç; Özgül, Ülkü; Parlakpınar, Hakan; Duran, Zeynep Rümeysa; Yıldız, Azibe; Durmuş, Mahmut (Advances in Clinical and Experimental Medicine, 2013)
    Objectives. The aim of this study was to investigate the possible protective effects of melatonin and β-d-glucan against ischemia-reperfusion (IR) injury in rats. Materials and Methods. Forty rats were randomly divided ...
  • Relationship between depression and loneliness in elderly and examination of influential factors 
    Aylaz, Rukiye; Aktürk, Ümmühan; Erci, Behice; Öztürk, Hatice; Aslan, Hakime (Archives of Gerontology and Geriatrics, 2012)
    This study was planned and conducted for the purpose of examining the relationship between depression and loneliness in elderly people and the influencing factors. The study was a descriptive and correlational study and ...
  • New arylalkyl azole derivatives showing anticonvulsant effects could have VGSC and or GABAAR affinity according to molecular modeling studies 
    Sarı, Suat; Karakurt, Arzu; Uslu, Harun; Kaynak, Filiz Betül; Çalış, Ünsal; Dalkara, Sevim (European Journal of Medicinal Chemistry, 2016)
    (Arylalkyl)azoles (AAAs) emerged as a novel class of antiepileptic agents with the invention of nafimidone and denzimol. Several AAA derivatives with potent anticonvulsant activities have been reported so far, however ...
  • Functionalized imidazolium and benzimidazolium salts as paraoxonase 1 inhibitors synthesis characterization and molecular docking studies 
    Karataş, Mert Olgun; Uslu, Harun; Alıcı, Bülent; Gökçe, Başak; Gençer, Nahit; Arslan, Oktay; Arslan, Nahide Burcu; Özdemir, Namık (Bioorganic & Medicinal Chemistry, 2016)
    Paraoxonase (PON) is a key enzyme in metabolism of living organisms and decreased activity of PON1 was acknowledged as a risk for atherosclerosis and organophosphate toxicity. The present study describes the synthesis, ...
  • Some coumarins and benzoxazinones as potent paraoxonase 1 inhibitors 
    Karataş, Mert Olgun; Alıcı, Bülent; Gökçe, Başak; Gencer, Nahit; Arslan, Oktay; Uslu, Harun (Journal of Enzyme Inhibition and Medicinal Chemistry, 2016)
    In this study, we aimed to investigate the effect of some coumarin and benzoxazinone derivatives on the activity of human PON1. Human serum paraoxonase 1 was purified from fresh human serum blood by two-step procedures ...
  • Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors synthesis molecular docking and anticonvulsant studies 
    Karataş, Mert Olgun; Uslu, Harun; Sarı, Suat; Alagöz, Mehmet Abdullah; Karakurt, Arzu; Alıcı, Bülent; Bilen, Çiğdem; Yavuz, Emre; Gençer, Nahit; Arslan, Oktay (Journal of Enzyme Inhibition and Medicinal Chemistry, 2016)
    Among many others, coumarin derivatives are known to show human carbonic anhydrase (hCA) inhibitory activity. Since hCA inhibition is one of the underlying mechanisms that account for the activities of some antiepileptic ...
  • Effects of interactions between various fats and active passive phases on postprandial inflammation in rats 
    Otlu, Hüsniye Gül; Kayhan, Başak; Güldür, Tayfun (Biological Rhythm Research, 2016)
    The circadian clock controls number of behavioral and physiological processes during daily light/dark cycle including inflammation and vascular injury. However, how reciprocal interaction of dietary fats and light/dark ...
  • Circadian rhythm in mammals time to eat time to sleep 
    Güldür, Tayfun; Otlu, Hüsniye Gül (Biological Rhythm Research, 2016)
    Circadian rhythm is defined as rhythmic fluctuations in physiological processes which enable living organisms to make necessary arrangements for upcoming changes in the environment thereby optimizing their metabolism. ...
  • Analysis of urine biomarkers for early determination of acute kidney injury in non septic and non asphyxiated critically ill preterm neonates 
    Karadağ, Ahmet; Elmas, Taner; Tabel, Yılmaz; Özdemir, Ramazan; Otlu, Hüsniye Gül (The Journal of Maternal-Fetal & Neonatal Medicine, 2016)
    Objective: We designed the present study to test the hypothesis that urinary biomarkers might predict acute kidney injury (AKI) development in non-septic and non-asphyxiated critically ill preterm infants. We evaluated ...
  • Bisphenol A Exposure Routes Metabolism and Toxicity 
    Otlu, Hüsniye Gül; Türköz, Yusuf (İnönü Üniversitesi Sağlık Bilimleri Dergisi, 2016)
    Gıda paketlerinde, konservelerde, kişisel bakım ürünlerinde, diş malzemelerinde ve günlük hayatta kullandığımız pek çok üründe bulunan Bisfenol A (BPA) gibi ksenobiyotikler, insan sağlığı için büyük tehdit oluşturmaktadır. Son ...
  • Poster Communications 
    Çay, Mahmut; Yılmaz, Nesibe; Şenol, Deniz; Çevirgen, Furkan; Uçar, Cihat; Özbağ, Davut (Acta Physiologica, 2016)
  • Polymorphisms in MMP 2 and TIMP 2 in Turkish patients with prostate cancer 
    Yaykaşlı, Kürşat Oğuz; Kayıkçı, Muhammet Ali; Yılmaz, Nesibe; Soğuktaş, Hatice; Düzenli, Selma; Arslan, Ali Osman; Metin, Ahmet; Kaya, Ertuğrul; Hatipoğlu, Ömer Faruk (TURKISH JOURNAL OF MEDICAL SCIENCES, 2014)
    Aim: Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) ...
  • Association between survivin gene polymorphisms and the susceptibility to colon cancer development in the turkish population 
    Yılmaz, Nesibe; Yaykaşlı, Kürşat Oğuz; Yılmaz, Ümit; Eröz, Recep; Uzunlar, Ali Kemal; Ankaralı, Handan; Şahiner, Cem; Baltacı, Davut (Asian Pacific Journal of Cancer Prevention, 2014)
    Background: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and ...
  • Investigation of ICAM 1 and 3 integrin gene variations in patients with brain tumors 
    Yılmaz, Ümit; Zeybek, Şakir Ümit; Timirci Kahraman,Özlem; Kafadar, Ali Metin; Toptaş, Bahar; Yılmaz, Nesibe; Çelik, Faruk; Yaylım, İlhan (Asian Pacific Journal of Cancer Prevention, 2013)
    Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. β3 integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor ...
  • Papiller Tiroid Kanserinde Braf T1799a Mutasyonunun Tumor Buyukluğune Etkisi 
    Yaykaşlı, Kürşat Oğuz; Yılmaz, Nesibe; Oktay, Murat; Yaykaşlı, Emine; Önder, Elif; Aydın Oktay, Nilay; Aydın, Yusuf (Düzce Üniversitesi Tıp Fakültesi Dergisi, 2013)
    Amaç: Tiroid kanseri en yaygın endokrin malinitesidir ve tüm dünyada insidansı giderek artmaktadır. Tüm tiroid kanseri vakalarının yaklaşık % 80’ini teşkil eden papiller tiroid kanserinin etyolojisinde başta T1799A ...
  • Investigation of survivin gene polymorphism in patients with gastric carcinoma 
    Yılmaz, Nesibe; Yaykaşlı, Kürşat Oğuz; Soğuktaş, Hatice; Oktay, Murat; Erdem, Havva; Kaya, Ertuğrul; Ekinci, Aysun; Kaya, Savaş (Dicle Medical Journal / Dicle Tip Dergisi, 2012)
    Amaç: Dünya genelinde mide kanserinin insidansı düş- mesine rağmen hala önemli bir sağlık problemidir. Türkiye’de ise yılda 30.000 yeni mide kanseri vakasıyla 2. en sık görülen kanserdir. Mide kanseri genetik ve ...
  • Meme kanserli hastalarda TIMP2 gen polimorfizmlerinin sıklığının araştırılması 
    Göksen Arslan, Ulviye; Özmerdivenli, Recep; Yaykaşlı, Kürşat Oğuz; Oktay, Murat; Erdem, Havva; Soğuktaş, Hatice; Yılmaz, Nesibe; Yaykaşlı, Emine (EUROPEAN JOURNAL OF MEDICAL SCIENCE, 2012)
    The breast cancers were placed in first rank among other cancer types in women, and second rank after lung cancer in terms of death in the World. It is estimated that this cancer has 20/100.000 frequency in east region ...
  • The protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouse 
    Baykalır, Burcu Gül; Çiftçi, Osman; Çetin, Aslı; Öztanır, Mustafa Namık; Başak, Neşe (Acta cir bras, 2016)
    ABSTRACT PURPOSE: To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS: Animals(n=40) ...