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    A case of multiple sclerosis presenting as eight and half syndrome
    (KIrıkkale Üniv Tıp Fak Dergisi, 2015) Kamışlı, Özden; Tecellioğlu, Mehmet; Özcan, Abdul Cemal
    We present a case young woman who presented with right gaze limitation and right eye limitation of adduction with horizontal nystagmus on abduction left side (one-and-a-half syndrome) in addition to a right-sided lower motor neuron facial nerve palsy which is called eight-and-a-half syndrome. The etiology in our patient was multiple sclerosis which was confirmed by medical history and magnetic resonance imaging.
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    Clitoral electromyography
    (The Journal of Urology, 2002) Yılmaz, Uğur; Soylu, Ahmet; Özcan, Abdul Cemal; Kamışlı, Özden
    Purpose The clitoris has several histomorphological and functional similarities to the penis. In this study we evaluated spontaneous and evoked electromyography activity in the clitoris. Materials and Methods We evaluated 11 healthy female volunteers with clitoral electromyography using a concentric needle electrode placed intracorporeally. The hand, foot and genital sympathetic skin responses, and spontaneous electrodermal activity were simultaneously recorded with silver surface electrodes. Another concentric needle electrode was placed subdermally on the mons pubis to differentiate clitoral activity from possible artifact. After recording spontaneous electromyography and electrodermal activity the left median nerve was stimulated to record evoked clitoral activity, and the sympathetic skin response in the hand, foot and genital regions. Results There was spontaneous electromyography activity in the corpus clitoris. All dermal sites, including the hand, foot and genital regions, showed spontaneous electrodermal activity. No spontaneous activity was recorded from the subdermal needle electrode. Distraction of attention and coughing increased the amplitude and frequency of spontaneous clitoral electromyography and electrodermal activity at all sites. After stimulating the left median nerve all sites except that of the subdermal needle electrode showed evoked activity. Conclusions The demonstrated evoked and spontaneous clitoral electromyography activity seems to indicate a sympathetic tonus of the corpus clitoris, as recorded from the corpus cavernosum of the penis in human males. Clitoral electromyography may be a useful objective assessment tool for evaluating female sexual dysfunction as well as genital autonomic innervation.
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    The effect of agoraphobia on oxidative stress in panic disorder
    (Psychiatry Investigation, 2013) Göğcegöz Gül, Işıl; Karlıdağ, Rıfat; Cumurcu, Hatice Birgül; Türköz, Yusuf; Özcan, Abdul Cemal; Erdemli, Erman
    We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
  • Küçük Resim Yok
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    P50 sensory gating in patients with vaginismus
    (Anatolian Journal of Psychiatry, 2015) Göğcegöz Gül, Işıl; Karlıdağ, Rıfat; Özcan, Abdul Cemal
    Birincil vajinismus (BV) hastalarında cinsel birleşme sırasında, birbiriyle ilişkisiz uyaranların algılanarak baş etme kapasitelerinin üstünde bir stres etkeni olarak yorumlanması ve duyusal bilgi işleme süreçlerinde bir bozukluk, vulvovajinada ağrı duyma ile ilgili korku/kaygı duyma ile ilişkili olabilir varsayımıyla BV hastalarında P50 duyusal kapılama araştırıldı. Yöntem: BV tanısı konan 17-38 yaşları arasında 35 hasta ile yaş ve cinsiyet açısından eşleştirilmiş 29 sağlıklı gönüllüye nörofizyoloji laboratuvarında P50 kayıtlaması yapıldı ve sonuçlar karşılaştırıldı. Sonuç- lar: BV grubunun kontrol grubuna göre P50 kapılama oranı ve S1 amplitüdü istatistiksel olarak anlamlı düzeyde düşük saptandı. Tartışma: Beyne gelen uyaranların filtrelenmesinde ve uygun davranışsal yanıtın oluşturulmasında gerekli olan duyusal kapılamanın BV grubunda azalması iç ve dış çevreden gelen, gereğinden fazla ve birbiriyle ilişkisiz uyaranların algılanarak baş etme kapasitelerinin üstünde bir stres etkeni olarak yorumlanmasına neden olabilir. Araştırmamız BV hastalarında duyusal kapılamayı değerlendiren ilk çalışma olduğundan, daha geniş hasta gruplarıyla yapılacak yeni çalışmalara gereksinme vardır.