The effect of agoraphobia on oxidative stress in panic disorder
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Psychiatry Investigation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We
measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant
levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a
significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the
control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants
were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There
was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated
that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings
suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
Açıklama
Anahtar Kelimeler
Agoraphobia, Free radical, Panic disorder, Oxidative stress, Total antioxidant capacity
Kaynak
Psychiatry Investigation
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
4
Künye
Göğcegöz Gül, I. Karlıdağ, R. Cumurcu, H. B. Türköz, Y. Özcan, A. C. Erdemli, E. (2013). The effect of agoraphobia on oxidative stress in panic disorder. Psychiatry Investigation 10(4), 317–325.
