The effect of agoraphobia on oxidative stress in panic disorder

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dc.contributor.authorGöğcegöz Gül, Işıl
dc.contributor.authorKarlıdağ, Rıfat
dc.contributor.authorCumurcu, Hatice Birgül
dc.contributor.authorTürköz, Yusuf
dc.contributor.authorÖzcan, Abdul Cemal
dc.contributor.authorErdemli, Erman
dc.date.accessioned2017-05-19T11:50:27Z
dc.date.available2017-05-19T11:50:27Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.en_US
dc.identifier.citationGöğcegöz Gül, I. Karlıdağ, R. Cumurcu, H. B. Türköz, Y. Özcan, A. C. Erdemli, E. (2013). The effect of agoraphobia on oxidative stress in panic disorder. Psychiatry Investigation 10(4), 317–325.en_US
dc.identifier.doi10.4306/pi.2013.10.4.317en_US
dc.identifier.endpage325en_US
dc.identifier.issn1738-3684
dc.identifier.issue4en_US
dc.identifier.startpage317en_US
dc.identifier.urihttp://synapse.koreamed.org/DOIx.php?id=10.4306/pi.2013.10.4.317
dc.identifier.urihttps://hdl.handle.net/11616/6907
dc.identifier.volume10en_US
dc.language.isoenen_US
dc.publisherPsychiatry Investigationen_US
dc.relation.ispartofPsychiatry Investigationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgoraphobiaen_US
dc.subjectFree radicalen_US
dc.subjectPanic disorderen_US
dc.subjectOxidative stressen_US
dc.subjectTotal antioxidant capacityen_US
dc.titleThe effect of agoraphobia on oxidative stress in panic disorderen_US
dc.typeArticleen_US

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