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Öğe Acute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patients(Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011) Kartalcı, Şükrü; Bay Karabulut, Aysun; Özcan, Abdulcemal; Porgalı, Esra; Ünal, SüheylaElectroconvulsive therapy (ECT) is an effective treatment alternative for schizophrenia. Previous studies have already indicated the possible effects of oxidative stress in this disorder. However, there have been no previous studies evaluating the effects of ECT on the oxidative stress in these patients. We therefore aimed to investigate the acute and chronic effects of ECT on serum levels of oxidant and antioxidant molecules in schizophrenia patients (n= 28). The serum MDA and CAT levels of the patients with schizophrenia were higher than that of the controls before ECT (n= 20) but there was no significant difference in the serum NO and GSH levels of the patient groups compared to the controls. We found that the NO levels of the patients were higher than the controls in the group experiencing their first episode but not in the chronic group. There was a significant clinical improvement in the patients in terms of BPRS, SANS and SAPS reduction after the 9th ECT, but not the 1st ECT. Serum MDA levels were significantly reduced compared to the baseline after the 9th ECT session although there was no significant difference after the 1st session. Separate evaluation of the patient groups revealed that the significant MDA decrease following ECT was in the patients experiencing their first episode and not in the chronic group. No significant difference was noted in the serum levels of other oxidant and antioxidant molecules after either the 1st or 9th ECT session. These results suggest that ECT does not produce any negative effect on oxidative stress in patients with schizophrenia.Öğe Auditory event related potentials in patients with premature ejaculation(Urology, 2001) Özcan, Abdulcemal; Özbek, Emin; Soylu, Ahmet; Yılmaz, Uğur; Güzelipek, Mehmet; Balbay, DeryaObjectives. To investigate in a descriptive manner the P300 component of the event-related potential (ERP), which is related to aspects of cognitive processing, in patients with premature ejaculation (PE) to determine whether there is a cognitive alteration in this condition. Recent studies with short latency evoked potentials such as cortical somatosensory evoked potentials have indicated that afferent sensory inputs from the genital area to the nervous system are increased in PE. However, the cortical neural process of ejaculation has remained poorly understood. Methods. We performed ERPs in 20 patients with PE and in 20 age-matched healthy subjects. ERPs were evoked by an auditory oddball paradigm consisting of 150 tone bursts (80% 1 kHz; 20% 2 kHz). The latencies of the N200 and the P300 waves and the amplitude of the P300 wave were measured. Results. The mean latencies of the N200 and P300 waves were significantly longer in the patients with PE than in the controls (P 0.04 and 0.03, respectively). No significant difference was found in the P300 amplitude between the controls and patients (P 0.05). Conclusions. These data indicate that the greater cortical representation of sensory stimuli from the genital areas that has been shown with somatosensory evoked potential studies might be related to a cognitive/ neurobehavioral dysfunction. The dysfunction involves an increased time to evaluate and categorize the stimuli in the central nervous system, with no change in the quality of cognition and neural disinhibition by the prefrontal cortex to early sensory processing in subcortical or primary cortical regions, which are cognitive neural processes underlying ERP generation.Öğe Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus(Neuroradiology, 2005) Saraç, Kaya; Akıncı, Ayşehan; Alkan, Alpay; Aslan, Mehmet; Baysal, Tamer; Özcan, AbdulcemalAbstract The metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9±3.4 (8.2–19.4). The average number of keto-acidosis episodes was 1.9±2.2 (0–9) and the average number of daily insulin injections was 2.8±0.97 (2–4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover.Öğe Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type1 diabetes mellitus(NEURORADIOLOGY, 2005) Saraç, Kaya; Akıncı, Ayşehan; Alkan, Alpay; Aslan, Mehmet; Baysal, Tamer; Özcan, AbdulcemalThe metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9±3.4 (8.2–19.4). The average number of keto-acidosis episodes was 1.9±2.2 (0–9) and the average number of daily insulin injections was 2.8±0.97 (2–4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover.Öğe Caffeic acid phenethyl ester CAPE attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels(International Journal of Developmental Neuroscience, 2006) Aladağ, Mehmet Arif; Türköz, Yusuf; Özcan, Abdulcemal; Şahna, Engin; Parlakpınar, Hakan; Akpolat, Nusret; Çiğremiş, YılmazBackground: Cerebral vasospasm, a medical complication of aneurysmal subarachnoid hemorrhage (SAH), is associated with high morbidity and mortality rates, even after the aneurysm has been secured surgically or endovascularly. Evidence accumulated during the last decade suggest that scavenging a vasodilator, nitric oxide (NO), by superoxide anions (O2 ), and activating a strong vasoconstructor, protein kinase C (PKC), are the two most important mechanisms in the pathogenesis of vasospasm. Our aim in this study was to determine whether caffeic acid phenethyl ester (CAPE), a non-toxic oxygen free radical scavenger, prevents vasospasm in an experimental rat model of SAH. Methods: Twenty eight rats (225–250 g) were divided into four groups equally: group 1, control group; group 2, SAH group; group 3, SAH plus placebo group; and group 4, SAH plus CAPE group. We used double haemorrhage method for SAH groups. Starting 6 h after SAH, 10 mmol/kg CAPE or an equal volume of 0.9% saline were administered by intraperitoneal injection twice daily for 5 days to SAH plus CAPE and SAH plus placebo groups, respectively. CAPE or 0.9% saline injections were continued up to 5th day after SAH. Rats were sacrificed on the 5th day. Brain sections at the level of the pons were examined by light microscopy. Measurements were made for the cross-sectional areas of the lumen and the vessel wall (intimae plus media) of basilar artery by a micrometer. The levels of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) were measured in rat brain tissue. Results: Administration of CAPE significantly attenuated the vasoconstriction of the basilar artery. There were marked narrowing in the lumens of and thickening in the walls of basilar arteries in the SAH, and the SAH plus placebo compared with CAPE group ( p < 0.001). We also observed that CAPE administration significantly decreased the tissue level of MDA, while significantly increased the tissue levels of GSH, NO in the SAH plus CAPE group compared to only SAH group, p < 0.05. Conclusions: Our results indicate that CAPE is effective in attenuating delayed cerebral vasoconstriction following experimental SAH. Our findings also suggest that the elevation of lipid peroxidation and reduction of NO bioavailability, resulting from the generation and the interaction of free radicals, have a significant role in the pathogenesis of vasospasm after SAH.Öğe Central pontine myelinolysis in Wilson s disease MR spectroscopy findings(Magnetic Resonance Imaging, 2004) Kızkın, Sibel; Kaya, Saraç; Özışık Karaman, Handan Işın; Özcan, AbdulcemalAlthough a pontine lesion on cranial MRI is frequently associated with an extrapontine lesion, few cases report solitary pontine involvement in Wilson disease, and it is usually recognized as central pontine lesions related to hepatic dysfunction. A patient with Wilson’s disease having a solitary pontine lesion without basal ganglia involvement in cranial MRI with cerebellar symptoms is presented. Based on MR spectroscopy findings, this solitary pontine lesion could be regarded as central pontine myelinolysis rather than the neurologic involvement in Wilson’s disease.Öğe Cerebral artery hemodynamics in polycystic ovary syndrome(Gynecological Endocrinology, 2005) Kızkın, Sibel; Engin Üstün, Yaprak; Üstün, Yusuf; Özcan, Abdulcemal; Serbest, Semih; Özışık Karaman, Handan IşınObjective. The aim of the present study was to investigate hemodynamic changes in the medial cerebral artery and also the internal carotid artery in young women with polycystic ovary syndrome (PCOS) and polycystic ovaries (PCO). Methods. Twenty-eight patients with PCOS, 16 patients with PCO and 24 healthy control subjects were included in the study. Blood flow rate, pulsatility index and back pressure of both the medial cerebral artery and the internal carotid artery were determined by transcranial Doppler ultrasonography and the results compared between groups. Results. There were no significant differences between the groups in bilateral medial cerebral artery and internal carotid artery blood flow rate, pulsatility index and back pressure. Conclusion. Our results do not indicate whether the risk of cerebrovascular events will increase for PCOS patients in middle and advanced age, but do show that changes in cerebral hemodynamics are not likely in PCOS at an early stage.Öğe Comparison of nerve vessel and cartilage grafts in promoting peripheral nerve regeneration(Annals of plastic surgery, 2013) Fırat, Cemal; Geyik, Yılmaz; Aytekin, Ahmet Hamdi; Gül, Mehmet; Kamışlı, Suat; Yiğitcan, Birgül; Özcan, AbdulcemalAbstract: Peripheral nerve injury primarily occurs due to trauma as well as factors such as tumors, inflammatory diseases, congenital deformities, infections, and surgical interventions. The surgical procedure to be performed as treatment depends on the etiology, type of injury, and the anatomic region. The goal of treatment is to minimize loss of function due to motor and sensory nerve loss at the distal part of the injury. Regardless of the cause of the injury, the abnormal nerve regeneration due to incomplete nerve regeneration, optimal treatment of peripheral nerve injuries should provide adequate coaptation of proximal and distal sides without tension, preserving the neurotrophic factors within the repair line. The gold standard for the treatment of nerve defects is the autograft; however, due to denervation of the donor site, scarring, and neuroma formation, many studies have aimed to develop simpler methods, better functional results, and less morbidity. In this study, a defect 1 cm in length was created on the sciatic nerve of rats. The rats were treated with the following procedures: group 1, autograft; group 2, allogeneic aorta graft; group 3, diced cartilage graft in allogeneic aorta graft; and group 4, tubularized cartilage graft in allogeneic aorta graft. Group 5 was the control group. The effects of cartilage tissue in nerve regeneration were evaluated by functional and histomorphological methods. Group 1, for which the repair was performed with an autograft, was evaluated to be the most similar to the control group. There was not a statistically significant difference in myelination and Schwann cell rates between group 2, in which an allogeneic aorta graft was used, and group 3, in which diced cartilage in an allogeneic aorta graft was used. In group 4, myelination and Schwann cell formation were observed; however, they were scattered and irregular, likely due to increased fibrosis. In all of the groups, nerve regeneration at various rates was observed both functionally and histomorphologically. This study demonstrates that cartilage tissue has promoting effects in nerve regeneration.Öğe Comparison of three conservative treatment protocols in carpal tunnel syndrome(INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2006) Baysal, Özlem; Altay, Zühal; Özcan, Abdulcemal; Ertem, Kadir; Yoloğlu, Saim; Aycan, KayhanThe aim of this study was to investigate and compare the therapeutic effect of three different combinations in the conservative treatment of carpal tunnel syndrome (CTS) by means of clinical and electrophysiological studies. The combinations included tendon- and nerve-gliding exercises in combination with splinting, ultrasound treatment in combination with splinting and the combination of ultrasound, splinting, tendon- and nerve-gliding exercises. A total 28 female patients (56 wrists) with clinical and electrophysiologic evidence of bilateral CTS were studied. In all patient groups, the treatment combinations were significantly effective immediately and 8 weeks after the treatment. The results of the long-term patient satisfaction questionnaire revealed that symptomatic improvement is more prominent in the group treated with splinting, exercise and ultrasound therapy combination. Our results suggest that a combination of splinting, exercise and ultrasound therapy is a preferable and an efficacious conservative type of treatment in CTS.Öğe Complex partial status epilepticus(CLINICAL ELECTROENCEPHALOGRAPHY, 1988) Komşuoğlu, Sezer Şener; Özcan, Abdulcemal; Özmenoğlu, Mehmet; Gürhan, HasanÖğe Decreased endothelium dependent vasodilatation in patients with migraine a new aspect to vascular pathophysiology of migraine(Coronary Artery Disease, 2006) Ertan, Yetkin; Özışık Karaman, Handan Işın; Özcan, Abdulcemal; Aksoy, Yüksel; Turhan, HasanBackground Migraine is a common neurovascular disorder characterized by attacks of severe headache, autonomic and neurological symptoms. We hypothesized that patients with migraine had abnormal endothelial function. The vascular theory of migraine assumes that the major pathophysiological events that initiate the migraine attack occur in the perivascular nerves of the major cerebral vessels. Accordingly, we aimed to measure endothelium-dependent vasodilatation in migraineurs by means of flow-mediated dilatation, which reflects endothelium-dependent vasodilatation capacity. Materials and methods Forty-five patients who fulfilled the diagnostic criteria for migraine and 45 age and sexmatched healthy participants were enrolled in the study. Flow-mediated dilatation of the brachial artery was determined using a high-resolution B-mode ultrasonographic system. Flow-mediated vasodilatation was expressed as the change in post-stimulus diameter as a percentage of the baseline diameter. Results Mean ages of the patients were 33 ± 10 years in migraineurs (range: 18–52 years, 36 female, 9 male) and 33 ± 9 years in non-migraineurs (range: 17–50 years, 36 female and 9 male). Flow-mediated dilatation of patients with migraine is significantly lower than that of the controls (8.02 ± 4.095% vs. 10.72 ± 3.52%, respectively, P = 0.001). Conclusion We have shown that migraineurs have decreased endothelium-dependent vasodilatation capacity compared with non-migraineurs. Migraine may be a local manifestation of systemic vascular vasomotion abnormalities.Öğe The effect of human placental suspension on rat sciatic nerve healing(Acta Orthopaedica et Traumatologica Turcica, 2007) Ayran, İrfan; Esenkaya, İrfan; Karakaplan, Mustafa; Germen, Burak; Milcan, Abdullah; Özcan, Abdulcemalİnsan plasenta süspansiyonunun sıçan periferik sinir rejenerasyonundaki etkisi araştırıldı. Çalışma planı: Çalışmaya ağırlıkları 250-300 gr arasında değişen, sekiz adet erişkin Sprague-Dawley türü dişli sıçan alındı. Sıçanlar kontrol (n=4) ve denek (n=4) olmak üzere iki gruba ayrıldı. Sıçanların her iki siyatik siniri anestezi altında eksplore edilip kesildi ve hemen tamir edildi. Tamir bölgesine işlem sonunda ve ikinci ve beşinci günlerde, test grubunda insan plasenta süspansiyonu, kontrol grubunda ise serum fizyolojik uygulandı. Cerrahi öncesinde ve sekizinci haftanın sonunda fonksiyonel değerlendirme için sıçanların her iki alt ekstremitesine elektromiyografi yapıldı. Sekizinci hafta sonunda histopatolojik değerlendirme için sıçanların yaşları sonlandırıldı ve tamir bölgesi ve distalinden alı- nan kesitler incelenerek miyelinli akson sayımı yapıldı. Sonuçlar: Elektromiyografik değerlendirmede her iki grupta da girişim sonrasında, girişim öncesine göre latans değerlerinde uzama, amlitüd değerlerinde azalma görüldü. Bu değişimler test grubunda biraz daha az olmasına rağmen kontrol grubuyla arasında anlamlı fark yoktu (p>0.05). Kontrol grubunda en belirgin bulgu endonöral kollajen artışlı iken, test grubunda rejeneratif aksonal de- ğişikliklerin varlığıydı. Her iki grupta da distaldeki akson sayıları tamir bölgesinden fazla bulundu. Tamir bölgesindeki ve distal bölgedeki miyelinli akson say›m› test grubunda daha fazlaydı; ancak, bu farklılık sadece tamir bölgesindeki akson sayısında anlamlı düzeydeydi (p=0.001). Çıkarımlar: insan plasenta süspansiyonunun periferik sinir rejenerasyonunu olumlu etkileyebilece¤i sonucuna varıldı.Öğe Ergen hastada aripiprazole bağlı nöroleptik malign sendrom bir olgu sunumu(Nöro Psikiyatri Arşivi, 2011) Kamışlı, Özden; Özcan, Özlem; Kaplan, Yüksel; Özcan, AbdulcemalNöroleptik Malign Sendrom(NMS) sıklıkla antipsikotik kullanımına bağlı, nadir görülen bir sendromdur. Bu sendromda genellikle hipertermi, kas rigiditesi, otonomik bozukluklar, mental durum değişiklikleri, tremor, serum kreatinfosfokinaz yüksekliği ve lökositoz görülür. Aripiprazol flizofreni tedavisinde kullanılan yeni bir antipsikotiktir. Bu yazıda otizm ve mental retardasyon tanısı ile takip edilen ergen bir hastada düflük doz aripiprazol kullanımı ile ortaya çıkan NMS tablosu tartışılacaktır.Öğe Hesperidin a citrus flavonoid has the ameliorative effects against experimental autoimmune encephalomyelitis EAE in a C57BL J6 mouse model(Neurochemical Research, 2015) Çiftçi, Osman; Özcan, Abdulcemal; Kamışlı, Özden; Çetin, Aslı; Başak, Neşe; Bilal, AytaçThe aim of this study was determined the effects of Hesperidin (HP) on neuronal damage in brain tissue caused by Experimental allergic encephalomyelitis (EAE), an established model of multiple sclerosis in C57BL/J6 mice. To explore 40 mice were equally divided into four groups: (1) Control, (2) EAE, (3) HP, and (4) HP ? EAE. 14 days after induction of EAE with MOG35- 55 and pertussis toxin, the mice treated with HP at the doses of 50 mg/kg/day for 7 days subcutaneously. To our results HP treatment prevents the oxidative stress caused by EAE via a decrease in lipid peroxidations and increase in elements of the antioxidant defense systems in brain tissue. Also, EAE elevate the IL-17, express the pro-in- flammatory cytokines, and caspase-3-like immunreactivity, show apoptosis, staining in EAE mice brain and increased the incidence of histopathological damage. However, immonohistochemical and histological changes were reversed with HP. Moreover, elevated TNF-a and IL-1b levels, a result of EAE, were decreased in serum and neurological deficits as clinical signs were reversed with HP treatment in EAE mice, given HP. In conclusion, HP treatment effectively prevents oxidative, immunological and histological damage in the brain caused by EAE. It was thought that the beneficial effects of HP are likely a result of its strong antioxidant and anti-inflammatory properties.Öğe Hesperidin protects brain and sciatic nerve tissues against cisplatin induced oxidative histological and electromyographical side effects in rats(Toxicology and Industrial Health, 2015) Kamışlı, Suat; Çiftçi, Osman; Kaya, Kürşat; Çetin, Aslı; Kamışlı, Özden; Özcan, AbdulcemalIn the present study, the beneficial effect of hesperidin (HP), a citrus flavonoid, on cisplatin (CP)-induced neurotoxicity was investigated. A total of 28 rats were equally divided into four groups; the first group was kept as control. In the second and third groups, CP and HP were given at the doses of 7 and 50 mg/kg/day, respectively. In the fourth group, CP and HP were given together at the same doses. The results indicated that although CP caused significant induction of lipid peroxidations and reduction in the antioxidant defense system potency in the brain and sciatic nerve, HP prevented these effects of CP. Besides, CP led to histopathological damage, mainly apoptosis, as well as electromyographical (EMG) changes in sciatic nerve. On the other hand, HP treatment reversed histopathological and EMG effects of CP. In conclusion, CP had severe dose-limiting neurotoxic effects and these effects of CP can be prevented by HP treatment. Thus, it appears that coadministration of HP with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.Öğe Increased dilator response to nitrate and decreased flow mediated dilatation in migraineurs(Headache: The Journal of Head and Face Pain, 2007) Yetkin, Ertan; Özışık, Handan Işın; Özcan, Abdulcemal; Aksoy, Yüksel; Turhan, HasanBackground.—It has been known that in a migraine attack intracranial and extracranial arteries on the headache side dilate and when the migraine attack has subsided, the intracranial arteries show segmental narrowing. We hypothesized that patients with migraine had an underlying systemic vasomotion abnormality and there might be an increased nitrate-mediated vasodilatory response in the brachial artery of migraineurs. Accordingly we aimed to measure endothelium dependent and independent functions of brachial artery in migraineurs and healthy subjects. Materials and Methods.—Twenty-four patients who fulfilled the diagnostic criteria of migraine were enrolled in the study. Twenty-six age- and sex-matched healthy control subjects comprised the control group. Flow-mediated dilatation and nitrate-mediated dilatation were measured in all patients and control subjects by means of brachial artery ultrasonography. Results.—Flow-mediated dilatation of patients with migraine was significantly lower than that of control subjects (7.6 ± 3.7% vs 10.4 ± 3.5%, respectively, P = .008). However, nitrate-mediated dilatation in migraineurs was significantly higher than that of nonmigraineurs (25% vs 14%, respectively, P< .001). Conclusion.—We have shown that migraineurs have decreased endothelium dependent function whereas increased nitrate-mediated response in their brachial artery. It can be suggested that the mechanism underlying migraine may be a diffuse vascular vasomotion abnormalities and migraine may be a local manifestation of systemic vascular abnormality rather than a primary cerebral phenomenon.Öğe Isolated intracranial hypertension a rare presentation of neurobrucellosis(Microbes and Infection, 2004) Özışık Karaman, Handan Işın; Ersoy, Yasemin; Tevfik, Mehmet Refik; Kızkın, Sibel; Özcan, AbdulcemalBrucella melitensis infection is endemic in the eastern and south-eastern Anatolia regions of Turkey. We report an unusual case of brucella meningitis presenting with bilateral papilla stasis, diplopia and absence of other neurological involvement. Diagnosis was made by positive culture of Brucella spp. with a BACTEC 9120 system with inoculation of the patient’s cerebrospinal fluid (CSF). This is the first report of isolation of Brucella spp. from CSF on a BACTEC 9120 system for diagnosis of meningitis. This case demonstrated that brucella meningitis may present with very slight symptoms, and inoculation of CSF into BACTEC bottle besides conventional cultures improves the detection of Brucella in endemic areas such as Turkey.Öğe Jaffe campanacci syndrome and non convulsive status epilepticus a case report(NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, 2010) Kamışlı, Özden; Kamışlı, Suat; Altınayar, Sibel; Kaplan, Yüksel; Özcan, AbdulcemalJaffe Campanacci sendromu non-ossifiye fibromlar ve cafe au lait lekelerinden oluflur. Baz› hastalarda mental retardasyon görülebilmektedir. Nonkonvülzif status epileptikus, çeflitli hastal›klarla iliflkili olabilmektedir. Bununla birlikte, bildi¤imiz kadar›yla bu iki durum aras›nda bir iliflki literatürde daha önce bildirilmemifl- tir. Biz bu yaz›m›zda Jaffe Campanacci sendromu olan ve nonkonvülzif status epileptikus geliflen bir hastay› sunduk.Öğe Lower extremity isokinetic muscle strength in patients with parkinson s disease(Journal of Clinical Neuroscience, 2010) Durmuş, Bekir; Baysal, Özlem; Altınayar, Sibel; Altay, Zühal; Özcan, AbdulcemalWe evaluated lower extremity isokinetic muscle strength to determine affected muscle groups and their dependence on movement velocity, and to establish the relationship between muscle strength and clinical severity, as well as muscle strength and falls, in Parkinson’s disease (PD). Twenty-five patients diagnosed with PD and 24 healthy volunteers were enrolled in this study. Lower extremity muscle strength was measured using an isokinetic dynamometer. Each participant’s clinical status was examined in accordance with the Unified Parkinson’s Disease Rating Scale; fall history was also recorded. We observed a significant decrease in isokinetic muscle strength in the patient group, especially in both hip and knee flexors and extensors. Decreased muscle strength was independent of velocity, and correlated with clinical severity and falls. Movement velocity-independent lower extremity isokinetic muscle weakness has been observed in patients with PD, especially in the knee and hip joints. The evaluation of isokinetic muscle strength may be a useful tool for the assessment of clinical severity and falls in PD.Öğe The neuropsychological and neurophysiological profile of women with pseudoseizure(Comprehensive Psychiatry, 2013) Han Almış, Behice; Cumurcu, Hatice Birgül; Ünal, Süheyla; Özcan, Abdulcemal; Aytaş, ÖzgürObjective: Our aim in this study was to compare the assessments of neuropsychological tests and the p50 neurophysiological test of patients with seizure diagnosed as conversion disorder and healthy control subjects, and to investigate the neurological status in conversion disorder with pseudoseizure. Methods: A total of 22 female conversion disorder patients with convulsions diagnosed according to SCID-I/CV and 22 healthy women were included in the assessment. The participants were administered WMS-R, the cancellation test, and the Stroop test as neuropsychological tests and p50 was assessed as a neurophysiological test. Results: The patient's results for the neuropsychological tests were found to be significantly low compared to the control group. The p50 sensory gating ratios of the patient group were statistically significantly lower than the controls. There was no significant correlation between the neuropsychological test scores and gating ratios of the patient and control groups. Conclusions: This study is the first to check sensory gating in conversion disorder patients with pseudoseizure and its most important result is finding reduced p50 sensory gating in patients. Our results suggest that these patients have a neurological tendency to this disease due to functional neurophysiological features.
