Increased dilator response to nitrate and decreased flow mediated dilatation in migraineurs
Yükleniyor...
Dosyalar
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Headache: The Journal of Head and Face Pain
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background.—It has been known that in a migraine attack intracranial and extracranial arteries on the headache
side dilate and when the migraine attack has subsided, the intracranial arteries show segmental narrowing. We
hypothesized that patients with migraine had an underlying systemic vasomotion abnormality and there might be
an increased nitrate-mediated vasodilatory response in the brachial artery of migraineurs. Accordingly we aimed to
measure endothelium dependent and independent functions of brachial artery in migraineurs and healthy subjects.
Materials and Methods.—Twenty-four patients who fulfilled the diagnostic criteria of migraine were enrolled
in the study. Twenty-six age- and sex-matched healthy control subjects comprised the control group. Flow-mediated
dilatation and nitrate-mediated dilatation were measured in all patients and control subjects by means of brachial
artery ultrasonography.
Results.—Flow-mediated dilatation of patients with migraine was significantly lower than that of control subjects
(7.6 ± 3.7% vs 10.4 ± 3.5%, respectively, P = .008). However, nitrate-mediated dilatation in migraineurs was
significantly higher than that of nonmigraineurs (25% vs 14%, respectively, P< .001).
Conclusion.—We have shown that migraineurs have decreased endothelium dependent function whereas increased
nitrate-mediated response in their brachial artery. It can be suggested that the mechanism underlying
migraine may be a diffuse vascular vasomotion abnormalities and migraine may be a local manifestation of systemic
vascular abnormality rather than a primary cerebral phenomenon.
Açıklama
Anahtar Kelimeler
Migraine headache, Endothelial function, Flow-mediated dilatation, Endothelium
Kaynak
Headache: The Journal of Head and Face Pain
WoS Q Değeri
Scopus Q Değeri
Cilt
47
Sayı
1
Künye
Yetkin, E. Özışık, H. I. Özcan, A. Aksoy, Y. Turhan, H. (2007). Increased dilator response to nitrate and decreased flow mediated dilatation in migraineurs. Headache: The Journal of Head and Face Pain. 47(1), 104–110.
