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    The evaluation of our newborns cases operated due to necrotizing enterocolitis
    (2017) Korkmaz, Levent; Baştuğ, Osman; Daar, Ghaniya; Korkut, Sabriye; Halis, Hülya; Özdemir, Ahmet; Ceylan, Mahir; Güneş, Tamer; Öztürk, Mehmet Adnan; Kurtoğlu, Selim
    Abstract:Aim: This study aimed to investigate the characteristics of newborns operated due to necrotizing enterecolitis (NEC) in newborn intensive care unit and to evaluate the mortality of these patients. Material and Methods: The research was designed retrospectively. The study included 39 patients operated due to NEC in our newborn intensive care unit between January 2010 and December 2015 and their characteristic factors and prognosis were evaluated. Results: The average gestational age and weight at birth of the newborns were 31.5±3.7 weeks, 1861±817 g respectively. There were significant differences between the newborns who died and survived in respect to birth weight, age at the time of operation, presence of antenatal steroid application, hypoxic ischemic encephalopathy, intestinal presence of perforation, blood culture positivity (p<0.05 for all comparisons). Conclusion: NEC is the most common life-threatening gastrointestinal emergency experienced by premature infants cared for in the newborn intensive care unit. It is thought that the most important ethiologic factors are prematurity, hypoxia and enteral nutrition. At the same time, it is a devastating gastrointestinal disease that is associated with severe sepsis, intestinal perforation, and significant morbidity and mortality. Its mortality and morbidity rates have been reduced due to developments in newborn intensive care. However, mortality rate is still high among newborns operated due to NEC. For these reasons our thought is that promptly arranged operation time can help to reduce the frequency of mortality.
  • Küçük Resim
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    Evaluation of our newborns with galactosemia
    (Turgut Özal Tıp Merkezi Dergisi, 2016) Korkmaz, Levent; Öztürk, Mehmet Adnan; Kardaş, Fatih; Daar, Ghaniya; Baştuğ, Osman; Kendirci, Mustafa; Akın, Ali; Korkut, Sabriye; Özdemir, Ahmet; Asçioğlu, Mustafa Erhan
    Abstract Objective: In this study, we aimed to help clinicians in the recognition and follow-up of galactosemia by emphasizing that this disease may manifest with different clinical pictures in the neonatal period Materials and Methods: This retrospective uncontrolled study included 19 patients diagnosed with galactosemia and followed-up between January 1994 and January 2014. Five of them had been previously diagnosed. Reductant agents in urine were evaluated using Benedict test, while galactose-1-phosphate uridyltransferase (GALT) was measured with kinetic, enzymatic, colorimetric measurement method. GALT mutation analysis was performed with the Tetraprimer Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) method. Galactose and free galactose were studied with the modified Diepenbrock colorimetric microassay method. Results: Eight (42.1%) of the patients were female and 11 (57.9%) male. Time of the suspicion for galactosemia was found as 11.5±6.3 days, while one patient (5.3%) had a familial history of galactosemia. The most common findings were nutritional intolerance (n=17, 89.5%), hypotonia (n=17, 89.5%) and organomegaly (n=15, 78.9%). The most commonly seen genetic disorder was GALT enzyme deficiency (n=12, 85.7%) and the most common mutation was the Q188R mutation (n=8, 66.6%). Conclusion: Galactosemia is a life threatening, but treatable disease with early diagnosis as well as being one of the metabolic diseases which cause confusion when clinically nonspecific findings are observed. Besides these clinical and laboratory findings, early diagnosis can be established by keeping in mind that galactosemia may present in infants having these findings. Keywords: Galactosemia; Neonate; Clinical And Laboratory Findings.