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    Effects of misoprostol on the endometrium of ovariectomized rats
    (2000) Sönmez A.S.; Birincio?lu M.; Aydin A.; Kiliç E.; Şahin N.
    Misoprostol (Cytotec, Searle, England), a prostaglandin E1 analogue, is indicated for protection of peptic disease induced by cyclo-oxygenase inhibitors. Since vaginal bleeding was reported during misoprostol use previously, we hypothesized that misoprostol might cause endometrial stimulation. Therefore, we investigated the effects of misoprostol on the endometrium of ovariectomized (OVX) rats to investigate any endometrial changes. Thirty-two, four month-old, parous female Sprague-Dawley rats were used in this study. All rats underwent ovariectomy at the beginning of the study. Sixty days after the ovariectomy six rats were sacrificed to remove the uterus and the remaining 26 rats were divided into three groups. Group I (six rats) was treated with vehicle (1 cc of distilled water orally) for 60 days. Groups II and II (ten rats each) were treated with oral 100 and 200 ?g/day misoprostol, respectively, for 60 days. At the end of the treatment laparotomy was performed and the uteri of all the rats were removed. Histopathologic examination of the endometrium 60 days after ovariectomy revealed endometrial atrophy. But after misoprostol administration a minimal endometrial proliferation was encountered regardless of the dose of misoprostol. The present study demonstrated that misoprostol can cause a proliferation in the endometrium after 60 days of administration. Long term studies are needed to evaluate if this proliferation leads to hyperplasia and cancer, especially in postmenopausal women.
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    The significance of MPV and N/L value in diagnosis of endometrial cancer
    (Gunes Kitap Kirtasiye, 2016) Yılmaz E.; Coşkun E.İ.; Şahin N.; Elkıran T.; Çıplak B.; Şimşek Y.
    Objective: Endometrial cancer is the most often determined malignancy. Beyond the factors like unopposed estrogen, endometrial hyperplasia, the existence of chronic inflammation has been thaugt as responsible also for the ethiology of endometrial cancer as in all tumours. In this study we tried to find out the role of chronic inflammation in endometrium cancer by using the hemaetologic markers like MPV, N/L. Material and Method: There has been 111 patients included in the study. Patients are diveded into four groups according to the endometrial tissue sampling results. Endometrial samplings are diagnosed in the pathology laboratory by their histopathologic characteristics. Total blood count is done by using Siemens Healthcare Diagnostic Item ADVIA 2120i. For the statistical analysis, SPSS 22.0, Chicago, IL programme has been used. Results: In the statistical analysis, there is not a significant difference of N/L ratios between groups (P>0.05). As the MPV values are examined, there has been significant difference between groups and in the endometrial cancer group, this value has been higher (p<0.001). Discussion: Chronic inflammation is an important factor in the ethiology of carcinogenesis. It has been showed that the cells causing inflammation; lymphocytes, platelets and especially neutrophils are increased in the tumoral tissue and their metabolisms are also increased in the tumoral tissue. It is not so different in gynecologic cancers like our study. In this case agents slowing down the inflammatory process, render an important part of the cancer therapy. © 2017 Gunes Kitap Kirtasiye. All rights reserved.
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    Struma ovarii: A rare case report
    (Gunes Kitap Kirtasiye, 2015) Yılmaz E.; Coşkun E.İ.; Şahin N.; Çıplak B.
    Objective: Struma ovarii is a rarely seen ovarian tumour that usually diagnosed in postoperative period by pathological examination. Case: 41 years old patient has been consulted by the department of gyneacology. A conglomerated right adnexial mass sized as 175X70 mm has been seen by transvaginal ultrasonography.It has been diagnosed as struma ovarii by the pathologic examination. Result: Struma ovarii has been a rare pathology. In this case report, whole characteristics of this pathologic tumour has been discussed. © 2015, Gunes Kitap Kirtasiye, All rights reserved.