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Öğe Chemistry and engineering of brush type polymers: Perspective towards tissue engineering(Elsevier, 2022) Acari, Idil Karaca; Sel, Evren; Ozcan, Imren; Ates, Burhan; Koytepe, Sueleyman; Thakur, Vijay KumarIn tissue engineering, it is imperative to control the behaviour of cells/stem cells, such as adhesion, proliferation, propagation, motility, and differentiation for tissue regeneration. Surfaces that allow cells to behave in this way are critical as support materials in tissue engineering. Among these surfaces, brush-type polymers have an important potential for tissue engineering and biomedical applications. Brush structure and length, end groups, bonding densities, hydrophilicity, surface energy, structural flexibility, thermal stability, surface chemical reactivity, rheological and tribological properties, electron and energy transfer ability, cell binding and absorption abilities for various biological molecules of brush-type polymers were increased its importance in tissue engineering applications. In addition, thanks to these functional properties and adjustable surface properties, brush type polymers are used in different high-tech applications such as electronics, sensors, anti-fouling, catalysis, purification and energy etc. This review comprehensively highlights the use of brush-type polymers in tissue engineering applications. Considering the superior properties of brush-type polymer structures, it is believed that in the future, it will be an effective tool in structure designs containing many different biomolecules (enzymes, proteins, etc.) in the field of tissue engineering.Öğe Determination of characterization, antibacterial and drug release properties of POSS- based film synthesized with sol-gel technique(Tubitak Scientific & Technological Research Council Turkey, 2021) Acari, Idil Karaca; Koytepe, Suleyman; Ates, Burhan; Yilmaz, Ismet; Seckin, Turgaythe study, antibacterial film synthesis was aimed using sol-gel technique from POSS structure with various functional groups. For this purpose, antibacterial properties have been acquired by metronidazole to the films to be synthesized. The films obtained were coated on glass surface samples by dip coating method. Antibacterial activities of surface coated glass samples were observed in E.coli and S. aureus bacteria. Metronidazole release studies in the film samples were followed by UV spectrophotometer. It was observed that drug release reached 68.90% at the end of the 24th h. As a result, it is thought that the synthesized film will be a good candidate especially for biomedical surface coating areas.Öğe The effects of Zn/Fe co-dopants on the structural, thermal, magnetic, and in vitro biocompatibility properties of calcium pyrophosphate ceramics(Elsevier, 2022) Kebiroglu, Hanifi; Ates, Tankut; Bulut, Niyazi; Ercan, Ismail; Ercan, Filiz; Acari, Idil Karaca; Koytepe, SuleymanIn the present work, calcium pyrophosphate (CPP) samples co-doped with Zn and Fe were prepared by using a wet chemical method, and their thermal, magnetic, structural, morphologic, and in vitro biocompatibility properties were investigated for the first time. X-ray diffraction (XRD) results showed that a continuous decreasing trend in two lattice parameters, unit cell volume, and average crystallite size was observed with the increasing Zn content. Zn content affected the magnetic and thermal behaviors, cell viability property of the CPP, as well as morphology. The sample containing 0.22 at.% Zn and 0.22 at.% Fe showed the best biocompatibility among all the samples, and the higher amount of Zn caused the lower cell viability. The bandgap of the CPP decreased with adding of Zn, while the linear absorption coefficient value increased.Öğe Immobilization of ?-Amylase onto Quantum Dots Prepared from Hypericum perforatum L. Flowers and Hypericum capitatum Seeds: Its Physicochemical and Biochemical Characterization(Springer/Plenum Publishers, 2023) Acari, Idil Karaca; Dik, Gamze; Bakar, Busra; Ulu, Ahmet; Onal, Yunus; Ates, BurhanEnzyme immobilization is an effective way to increase the catalytic activity and stability of the alpha-amylase (Amy) enzyme for industrial uses. For this purpose, carbon and graphene quantum dot (QDs) structures were prepared from Hypericum perforatum L. flowers (QD-1), and Hypericum capitatum seeds (QD-2) obtained from an herbalist in Hatay province of Turkey. Structural and morphological characterization of the prepared QDs and QDs/Amy were carried out by Fourier transform infrared spectrophotometer (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), and energy dispersive X-ray (EDX). Meanwhile, biochemical characterizations such as optimum pH and temperature, kinetic parameters, effects of metal ions, organic solvents, and trypsin digestion on enzyme activity were performed and compared with free Amy. The Amy enzyme was immobilized with an activity efficiency of 71.15% for QD-1/Amy, and 81.51% for QD-2/Amy under optimal conditions. The difference in activity efficiency between QD-1/Amy and QD-2/Amy was likely due to a change in the surface porosity of QDs structures. While the optimal pH value of all three forms of Amy was recorded as 6.0, their optimal temperature was found to be 40 degrees C. The activation energy (E-a) of the free Amy was found to be 4.81 kJ/mol, while it was 9.61 kJ/mol, and 3.20 kJ/mol for QD-1/Amy, and QD-2/Amy, respectively. K-m values were calculated as 1.18, 1.57, and 1.35 mg/mL for free Amy, QD-1/Amy, and QD-2/Amy, respectively, and V-max values were calculated as 37.52, 37.60, and 39.93 mu mol/min, respectively. Kinetic data revealed that the immobilized enzymes had lower substrate affinity compared to the free Amy. Besides, the QD-1/Amy and QD-2/Amy exhibited more stability than free Amy against metal ions, organic solvents as well as trypsin digestion due to the increment in conformational rigidity caused by changes in the secondary structures of the immobilized enzyme. For instance, after incubation with trypsin for 120 min, free Amy, QD-1/Amy, and QD-2/Amy retained approximately 20%, 35%, and 26% of initial activities, respectively. Finally, it can be proposed that the prepared carriers in this work may a useful to produce stable and active immobilized Amy to be used in industrial applications.Öğe Interaction of nickel ferrite nanoparticles with nucleic acids(Elsevier, 2022) Topkaya, Seda Nur; Acari, Idil Karaca; Kaya, Huseyin Oguzhan; Ozcan, Imren; Koytepe, Suleyman; Cetin, Arif E.In this article, we introduced an electrochemical biosensor employing graphite electrodes (GE) decorated with Nickel ferrite (NiFe2O4) nanoparticles for nucleic acid detection. NiFe2O4 nanoparticles in a narrow size distribution were synthesized with co-precipitation technique. Their chemical and crystallographic properties were characterized with FTIR and X-ray spectroscopies. Nanoparticle size distribution and hydrodynamic diameter were determined with particle size analyzer. Elemental content and purity of nanoparticles were analyzed with EDX analysis. Our analyses showed a diameter of similar to 10 nm for NiFe2O4 nanoparticles. Electrochemical properties of NiFe2O4 nanoparticles were examined with different analysis methods. Conductivity properties of NiFe2O4 nanoparticles were investigated with Cyclic Voltammetry (CV), which confirmed that nanoparticles on GE surface have a high surface area and conductivity. More importantly, in this article, the interactions between NiFe2O4 nanoparticles and double stranded DNA (dsDNA), single stranded DNA (ssDNA), and RNA were for the first time examined using Differential Pulse Voltammetry (DPV), CV, and Electrochemical Impedance Spectroscopy (EIS). Oxidation peak currents of NiFe2O4 nanoparticles and guanine bases of dsDNA, ssDNA, and RNA showed that NiFe2O4 nanoparticles effectively interacts with nucleic acids via an electrostatic mode.Öğe Preparation of 10-undecenoic acid based polyurethane/PCL fibers by electrospinning method and investigation of their antifungal properties(Springer, 2022) Acari, Idil Karaca; Boran, Filiz; Kolak, Seda; Tatlici, Eray; Yesilada, Ozfer; Koytepe, Suleyman; Ates, BurhanNowadays, in the treatment of such fungal infections, antifungal drugs in various forms are one of the most preferred methods. These medications can be in the form of creams and lotions, shampoos, pills, suppositories, powders, or sprays. The dose of the drugs is adjusted according to the type and growth area of the fungus, the severity of the symptoms, and the medical history of the patients. Dressing materials with antifungal properties are an alternative treatment method used for the treatment of fungal skin infections. These covers not only treat fungal infections but also prevent their spread. Within the scope of this study, polyurethane-based wound dressing materials (PU-UDA/PCL) with antifungal properties were developed. Electrospining method was used to produce these dressing materials and the surface area of the wound dressing material was increased, thereby increasing the effect of antifungal property. Polypropylene glycol, glycerol, and catechin as polyol were preferred in polyurethane (PU) synthesis. These structures were polymerized with isophorone diisocyanate and modified with 10-undecenoic acid. Obtained 10-undecenoic acid modified polyurethane (PU-UDA) structures were transformed into wound dressing structure with polycaprolactone (PCL) by electrospinning method. Structural, morphological, and thermal properties of the wound dressing materials were analyzed with different instrumental analysis methods. The antifungal activities of PU-UDA/PCL were tested. Antifungal tests were performed on C. albicans and C. tropicalis. Therefore, PU-UDA/PCL series could be used as an efficient antifungal agent. Finally, it was determined that the obtained 10-undecenoic acid-based polyurethane fibers have a suitable structure and feature for the treatment of many fungal infections.Öğe Preparation, characterization, and biocompatibility of chondroitin sulfate-based sol-gel coatings and investigation of their effects on osseointegration improvement(Taylor & Francis As, 2023) Pasahan, Aziz; Sevimli, Resit; Kivilcim, Nilufer; Acari, Idil Karaca; Erenler, A. Sebnem; Sezer, Selda; Durmat, H. TurgutIn this work, implants with enhanced antibacterial and surface properties besides mechanical, biological, and chemical properties were prepared with the replacement of traditional titanium and titanium alloys in the field of biomedical materials. Titanium substrates were coated with chondroitin sulfate (CS) containing (3-glycidoxypropyl)trimethoxysilane (GLYMO) and tetraethoxysilane (TEOS) based thin film using sol-gel technology. Chondroitin sulfate is a preferred material due to its characteristics antioxidative and osseointegresion properties besides its collagen-forming properties. Coated implants were morphologically elucidated with atomic force microscopy (AFM), and scanning electron microscopy (SEM). The structure of the chondroitin sulfate-containing films was investigated with Fourier Transform Infrared Spectroscopy (FTIR) and Energy Dispersive X-Ray Analysis (EDX) techniques. The obtained CS-based sol-gel surface coatings are thermally stable up to similar to 200 degrees C according to TGA and DTA analysis results. The biological and antibacterial properties of the coatings were also determined. The biocompatibility and osseointegration properties of the coatings developed within the scope of the study were, determined by in vivo studies on rats. According to biocompatibility results of CS/Sol-Gel coated surfaces, Cell viability (%) rates of CS-based coatings showed between 89 and 66%. According to the experimental data, it has been claimed that implants improved with antibacterial, stable, homogeneous, and biocompatible coatings can be used as a new alternative product for dental and orthopedic applications.Öğe Tuning electronic properties of hydroxyapatite through controlled doping using zinc, silver, and praseodymium: A density of states and experimental study(Elsevier Sci Ltd, 2024) Sahin, Binnur; Ates, Tankut; Acari, Idil Karaca; Barzinjy, Azeez A.; Ates, Burhan; Ozcan, Imren; Bulut, NiyaziThis study presents a comprehensive exploration of the electronic properties of hydroxyapatite (HA) doped with zinc (Zn), silver (Ag), and praseodymium (Pr). Five distinct compositions-0.4Pr-HA, 0.4Zn-0.4Pr-HA, 0.8Zn0.4Pr-HA, 0.4Ag-0.4Pr-HA, and 0.8Zn-0.4Pr-HA were systematically investigated through Density of States (DOS) and band structure calculations. The computed band gap values, ranging from 4.4037 to 4.1554 eV, revealed a progressive decrease in band gap energy from 0.4Pr-HA to 0.8Ag-0.4Pr-HA, emphasizing the substantial impact of dopant composition on electronic properties. Additionally, the incorporation of Pr induced distinct bands and peaks in the density of states, signifying the emergence of specific energy levels associated with Pr and suggesting a clear effect on the electronic structure. Furthermore, the study explores the influences of dopant type and quantity on the electronic structure, microstructure, spectral, thermal, and in vitro cell viability properties of Pr-based HA samples. Theoretical results demonstrated a continuous decrease in the bandgap with Ag or Zn dopants, and the study observed controllable changes in LAC values based on co-dopant type and quantity. Experimental outcomes revealed significant effects on crystallinity, crystallite size, lattice parameters, and unit cell volume, confirmed through XRD, SEM, EDX, FTIR, and Raman analyses. These findings provide valuable visions into the tunability of the electronic properties of HA through controlled doping with Zn, Pr, and Ag. This knowledge is crucial for modifying materials with desirable electronic properties, and thus holds promise for various applications in electronic devices and biocompatible coatings.
