Yazar "Aglamis, E." seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rats
    (Comenius Univ, 2014) Tasdemir, S.; Tasdemir, C.; Vardi, N.; Parlakpinar, H.; Aglamis, E.; Ates, B.; Sagir, M.
    Objective: The incidence of urinary bladder disturbances and renal structural changes and functional decline are found to increase with age. Methods: We investigated the effect of melatonin treatment in addition to estrogen replacement therapy in pine-alectomized (Px) and ovariectomized (Ovx) rats. 56 female Wistar rats were divided into seven groups, each containing eight animals: Sham, (Ovx), (Px), Px+Ovx, Px+Ovx receiving estrogen (Px+Ovx+E), Px+Ovx receiving melatonin (Px+Ovx+M) and Px+Ovx estrogen and melatonin supplemented (Px+Ovx+EM) group (EM group). We evaluated reduced glutathione (GSH) levels and malondialdehyde (MDA) levels. The mean collagen fiber (CF)/smooth muscle (SM) ratio in the bladder wall and structure of the kidney were examined histolologically. We aleso recorded response of the bladder contractility to acetylcholine (Ach). Results: Px and Ovx groups showed statistically significant reductions of antioxidant defenses, impaired Ach-evoked contraction, histological changes compared with the control group. Also, these changes were prominent in Px+Ovx group compared with all other groups. Both estrogen and melatonin reversed these changes however best restoration was observed in the EM group. Conclusions: Px performed in addition to Ovx led to a distinct increase in oxidative damage in bladder and renal tissue and deteriorate of the detrussor function. Either estradiol or melatonin replacement alone or in combination prevents significant alterations of tissue histology and bladder contractility following Ovx and Px. Thus, combination treatment appears to be the best method to restore both contractility and histomorphology of bladder and kidney tissues after Ovx and Px (Tab. 3, Fig. 4, Ref. 44). Text in PDF www.elis.sk.
  • Küçük Resim Yok
    Öğe
    Iatrogenic foreign body in bladder induced recurrent urinary tract infection: a case report
    (Verduci Publisher, 2011) Tasdemir, C.; Ogras, M. S.; Aglamis, E.
    Urinary tract infections (UTI) are the most common infections in women. Although these infections can be seen in healthy women without any anatomical and functional pathology in etiology, foreign bodies should also be considered. We present a foreign body case due to iatrogenic causes which had recurrent urinary tract infections for 5-6 months and that did not respond to medical treatment.
  • Küçük Resim Yok
    Öğe
    The role of National Institutes of Health category IV prostatitis in accurately staging the newly diagnosed prostate cancer
    (Springer London Ltd, 2013) Aglamis, E.; Tasdemir, C.; Ceylan, C.
    It has been known that the National Institutes of Health category IV (NIH-IV) prostatitis increases the serum total prostate-specific antigen (tPSA) in patients with benign prostatic hyperplasia. However, the effect of NIH-IV prostatitis on tPSA levels, which are used for staging prostate cancer (PCa) in patients with PCa, has not been previously investigated. To evaluate the effect of NIH-IV prostatitis on the tPSA which is used for staging PCa in patients with newly diagnosed PCa. A total of 198 patients in whom PCa was detected were included in the study. Group 1 included patients with only PCa, while Group 2 included patients with prostatitis and PCa. The tPSA levels of patients in Groups 1 and 2 were compared. A total of 120 (61 %) PCa (Group 1) and 78 (39 %) PCa + NIH-IV prostatitis (Group 2) patients were identified. The tPSA levels of 70 (58 %) patients in Group 1 and 22 (28 %) patients in Group 2 were at the interval of < 20 ng/ml (the mean levels of tPSA: 11.8 +/- A 4.5 and 14.1 +/- A 3.3, respectively). The tPSA levels of 50 (42 %) patients in Group 1 and 56 (72 %) patients in Group 2 were within the range of a parts per thousand yen20 ng/ml (the mean levels of tPSA: 39.9 +/- A 31.0 and 47.0 +/- A 29.2, respectively). Within both the < 20 ng/ml range and a parts per thousand yen20 ng/ml range, the mean tPSA value in Group 2 was found to be significantly higher than that of Group 1 (p = 0.03 and 0.01, respectively). The existence of NIH-IV prostatitis together with cancer in patients with PCa significantly increases the tPSA level which is used in staging the PCa.