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  • Küçük Resim
    Öğe
    Enfektif endokardite bağlı santral sinir sitemi septik embolisi: Otopsi olgu sunumu
    (İnönü Üniversitesi Tıp Fakültesi Dergisi, 2010) Türkkan, Dilhan; Yüksel, Fadime; Şamdancı, Türkmen Emine; Ak, Sibel
    Öz: Enfektif endokardit (EE) tedavi edilmediği takdirde hemen daima ölümle sonuçlanan bir hastalıktır. Burada, ense sertliği ve ateşe bağlı olarak menenjit öntanısı alan fakat bir çok sistemik emboli nedeniyle kaybedilen EE'li yirmiüç yaşındaki bir erkek hastanın klinik önemi ve postmortem dokularının histopatolojik bulguları sunulmuştur. Sistemik embolisi olan genç hastalarda etyolojide EE olabileceği vurgulanmıştır.
  • Küçük Resim Yok
    Öğe
    Evaluation of diagnostic performance of new antigen-based enzyme immune assay for diagnosis of Hepatitis C virus (HCV) infections
    (Academic Journals, 2012) Kooglu, Mehmet; Ak, Sibel; Ak, Muharrem; Yakupogullari, Yusuf; Ozer, Ali
    Laboratory diagnosis of Hepatitis C virus (HCV) is sometimes problematic. A novel immune enzyme assay (HCV-Core Antigen, Abbott Laboratories/Germany) has been recently licensed for detection of HCV antigen in human serum. In this study, we aimed to evaluate diagnostic performance of this new test in comparison with the HCV-RNA quantification and anti-HCV antibody (anti-HCV-Ab) analyses. A total of 152 serum samples of which 112 anti-HCV-Ab positive (range 1.08 to 386.54 s/co) and 40 anti-HCV-Ab negative (<1 s/co) were analyzed with HCV-RNA and HCV-Ag tests. According to HCV-RNA detection, sensitivity and specificity of HCV-Ag test was measured as 96.9 and 100%, respectively and of anti-HCV-Ab were measured as 100 and 60%, orderly. An excellent positive predictive value for HCV-Ag test was detected as 100%, whereas 28.5% for anti-HCV-Ab test. Pearson correlation analysis showed that there was a statistically significant and strong relationship (p < 0.001, R: 0.773) between HCV-Ag and HCV-RNA quantification analysis. The correlation between the two tests showed an exponential trend (R-2: 0.949). These results suggest that HCV-Ag test may be a reliable assay for HCV antigen detection, which is also well-correlated with serum viral load. However, large studies, including different HCV genotypes and with extreme viral quantity, are required to assess analytic potency of this novel kit.
  • Küçük Resim Yok
    Öğe
    Hydatid cyst of the ovary
    (Int Scientific Literature, Inc, 2010) Karaman, Ulku; Turkmen, Emine Samdanci; Birol, Fatih; Ak, Sibel; Kalayci, Ozlem Tugce; Beytur, Leyla
    Background: Echinococcus granulosus is a cestode that causes hydatid cyst disease with its larval form. The disease is often located in the liver; however, it may also be seen in the lungs, kidneys, spleen, brain, bone and heart. Case Report: A 38-year-old woman who had been operated on 4 years ago due to hydatid cyst disease located in the liver, presented at our clinic with pain in the epigastric and inguinal areas. The sonographic, serological and pathological evaluation of the patient leaded us to an uncommon presentation of hydatid cyst lodged in the ovarium. Conclusions: This case is reported to draw attention to unusual localizations of the hydatic cyst.