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    Comparison of Clinical and Angiographic Parameters Right Coronary Artery Shapes in Patients With Acute Myocardial Infarction from Right Coronary Artery
    (Elsevier Science Inc, 2013) Altintas, Mehmet Sait; Ermis, Necip; Cuglan, Bilal; Alturk, Erdal; Ozdemir, Ramazan
    [Abstract Not Available]
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    The effect of asthma controlling on heart rate recovery in patients with asthma
    (2022) Cuglan, Bilal; Akbaba Bagci, Belma; Altintas, Mehmet Sait; Altuntas, Emine
    Aim: The heart rate recovery index (HRRI) impairment was found in patients with pulmonary disease such as obstructive sleep apnea syndrome. Asthma is one of the most prevalent respiratory diseases in worldwide. In this study, we aimed to investigate the presence of HRRI impairment with asthma control test in patients with asthma. Material and Methods: A total of 45 people with asthma and 47 healthy participants were consequently enrolled to study from December 2019 through March 2020. The Asthma Control Test™(ACT) survey was used to evaluate the status of asthma. All participants were to undergo cardiopulmonary exercise testing. Heart rate recovery was calculated according to heart rate decreasing in recovery period. Results: Two groups had similar results in terms of laboratory parameters and demographic features. There was a statistically difference in exercise capacity, peak exercise heart rate, (METs) and duration of exercise. Also, all HRRI parameters were reached statistically significant when compared with control group. However, there was no statistically significance in HRRI when ACT groups were compared with each other. Conclusions: The differences of HRRI in ACT groups did not reach to statistically significance. This result could be a consequence of having only two ACT groups and not having any patients belonging to the well-controlled group.
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    The Relationship between Extracellular Volume Compartments and Matrix Metalloproteinases-2 in Left Ventricular Remodeling after Myocardial Infarction
    (Arquivos Brasileiros Cardiologia, 2022) Eyyupkoca, Ferhat; Eyerci, Nilnur; Altintas, Mehmet Sait; Felekoglu, Mehmet Ali; Biter, Halil Ibrahim; Hidayet, Siho; Sivri, Serkan
    Background: Matrix metalloproteinases (MMPs) can affect myocardial extracellular volume (ECV) and its compartments, and this can provide more detailed information about the mechanism of adverse left ventricular (LV) remodeling (AR) after acute myocardial infarction (MI).Objectives: To investigate the role of changes (Delta) in ECV compartments (matrix volume (MVi) and cell volume (CVi)) in the development of AR after MI, and their relationship with MMP-2 expressions.Methods: Ninety-two first MI patients who underwent 3 Tesla cardiovascular magnetic resonance imaging performed 2 weeks (baseline) and 6 months post-MI. We measured T1 mapping with MOLLI sequences. ECV was performed post-gadolinium enhancement. ECV and LV mass were used to calculate MVi and CVi. AR was defined as an increase of >= 12% in LV end-diastolic volume in 6 months. MMPs were measured using a bead-based multiplex immunoassay system at first day (baseline) and 2 weeks post-MI. P <0.05 was accepted as statistically significant.Results: Mean ECV and mean MVi baseline levels were higher in AR group compared to without AR group (42.9 +/- 6.4 vs 39.3 +/- 8.2%, p= 0.037; 65.2 +/- 13.7 vs 56.7 +/- 14.7 mL/m2, p=0.010; respectively). CVi levels was similar between groups. A positive correlation was found between baseline levels of MMP-2 and baseline levels of ECV (r=0.535, p<0.001) and MVi (r=0.549, p<0.001). Increased Delta MVi levels was independently predictor of AR (OR=1.03, p=0.010). Delta MVi had superior diagnostic performance compared to Delta ECV in predicting AR (Delta AUC: 0.215 +/- 0.07, p<0.001).Conclusion: High MVi levels are associated with AR, and Delta MVi was independently predictor of AR. This may be associated with MMP-2 release due to increased inflammatory response.