The Relationship between Extracellular Volume Compartments and Matrix Metalloproteinases-2 in Left Ventricular Remodeling after Myocardial Infarction
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Arquivos Brasileiros Cardiologia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Matrix metalloproteinases (MMPs) can affect myocardial extracellular volume (ECV) and its compartments, and this can provide more detailed information about the mechanism of adverse left ventricular (LV) remodeling (AR) after acute myocardial infarction (MI).Objectives: To investigate the role of changes (Delta) in ECV compartments (matrix volume (MVi) and cell volume (CVi)) in the development of AR after MI, and their relationship with MMP-2 expressions.Methods: Ninety-two first MI patients who underwent 3 Tesla cardiovascular magnetic resonance imaging performed 2 weeks (baseline) and 6 months post-MI. We measured T1 mapping with MOLLI sequences. ECV was performed post-gadolinium enhancement. ECV and LV mass were used to calculate MVi and CVi. AR was defined as an increase of >= 12% in LV end-diastolic volume in 6 months. MMPs were measured using a bead-based multiplex immunoassay system at first day (baseline) and 2 weeks post-MI. P <0.05 was accepted as statistically significant.Results: Mean ECV and mean MVi baseline levels were higher in AR group compared to without AR group (42.9 +/- 6.4 vs 39.3 +/- 8.2%, p= 0.037; 65.2 +/- 13.7 vs 56.7 +/- 14.7 mL/m2, p=0.010; respectively). CVi levels was similar between groups. A positive correlation was found between baseline levels of MMP-2 and baseline levels of ECV (r=0.535, p<0.001) and MVi (r=0.549, p<0.001). Increased Delta MVi levels was independently predictor of AR (OR=1.03, p=0.010). Delta MVi had superior diagnostic performance compared to Delta ECV in predicting AR (Delta AUC: 0.215 +/- 0.07, p<0.001).Conclusion: High MVi levels are associated with AR, and Delta MVi was independently predictor of AR. This may be associated with MMP-2 release due to increased inflammatory response.
Açıklama
Anahtar Kelimeler
Myocardial Infarction, metabolism, Ventricular Remodeling, Myofibroblasts, cytology, Matrix Metaloproteinase, TI Mapping
Kaynak
Arquivos Brasileiros De Cardiologia
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
119
Sayı
6
