The Relationship between Extracellular Volume Compartments and Matrix Metalloproteinases-2 in Left Ventricular Remodeling after Myocardial Infarction

Basit Öğe Kaydı
dc.authoridDemirtaş, Bekir/0000-0002-6266-2291
dc.authoridEyyupkoca, Ferhat/0000-0003-2630-3619
dc.authoridAltintas, Mehmet sait/0000-0001-8206-8268
dc.authoridAteş, Ömer Faruk/0000-0002-0281-1128
dc.authoridBiter, Halil ibrahim/0000-0002-5355-6729
dc.authoridHidayet, Siho/0000-0002-4103-9345
dc.authorideyerci, Nilnur/0000-0002-6293-3338
dc.authorwosidDemirtaş, Bekir/GRJ-5653-2022
dc.authorwosidEyyupkoca, Ferhat/AAE-9244-2022
dc.authorwosidAltintas, Mehmet sait/HSC-9027-2023
dc.authorwosidbiter, halilibrahim/HHZ-0989-2022
dc.authorwosidAteş, Ömer Faruk/AAA-1119-2020
dc.contributor.authorEyyupkoca, Ferhat
dc.contributor.authorEyerci, Nilnur
dc.contributor.authorAltintas, Mehmet Sait
dc.contributor.authorFelekoglu, Mehmet Ali
dc.contributor.authorBiter, Halil Ibrahim
dc.contributor.authorHidayet, Siho
dc.contributor.authorSivri, Serkan
dc.date.accessioned2024-08-04T20:53:14Z
dc.date.available2024-08-04T20:53:14Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Matrix metalloproteinases (MMPs) can affect myocardial extracellular volume (ECV) and its compartments, and this can provide more detailed information about the mechanism of adverse left ventricular (LV) remodeling (AR) after acute myocardial infarction (MI).Objectives: To investigate the role of changes (Delta) in ECV compartments (matrix volume (MVi) and cell volume (CVi)) in the development of AR after MI, and their relationship with MMP-2 expressions.Methods: Ninety-two first MI patients who underwent 3 Tesla cardiovascular magnetic resonance imaging performed 2 weeks (baseline) and 6 months post-MI. We measured T1 mapping with MOLLI sequences. ECV was performed post-gadolinium enhancement. ECV and LV mass were used to calculate MVi and CVi. AR was defined as an increase of >= 12% in LV end-diastolic volume in 6 months. MMPs were measured using a bead-based multiplex immunoassay system at first day (baseline) and 2 weeks post-MI. P <0.05 was accepted as statistically significant.Results: Mean ECV and mean MVi baseline levels were higher in AR group compared to without AR group (42.9 +/- 6.4 vs 39.3 +/- 8.2%, p= 0.037; 65.2 +/- 13.7 vs 56.7 +/- 14.7 mL/m2, p=0.010; respectively). CVi levels was similar between groups. A positive correlation was found between baseline levels of MMP-2 and baseline levels of ECV (r=0.535, p<0.001) and MVi (r=0.549, p<0.001). Increased Delta MVi levels was independently predictor of AR (OR=1.03, p=0.010). Delta MVi had superior diagnostic performance compared to Delta ECV in predicting AR (Delta AUC: 0.215 +/- 0.07, p<0.001).Conclusion: High MVi levels are associated with AR, and Delta MVi was independently predictor of AR. This may be associated with MMP-2 release due to increased inflammatory response.en_US
dc.identifier.doi10.36660/abc.20220061
dc.identifier.endpage957en_US
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.issue6en_US
dc.identifier.pmid36541989en_US
dc.identifier.scopus2-s2.0-85143720217en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage946en_US
dc.identifier.urihttps://doi.org/10.36660/abc.20220061
dc.identifier.urihttps://hdl.handle.net/11616/101050
dc.identifier.volume119en_US
dc.identifier.wosWOS:000904464400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherArquivos Brasileiros Cardiologiaen_US
dc.relation.ispartofArquivos Brasileiros De Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMyocardial Infarctionen_US
dc.subjectmetabolismen_US
dc.subjectVentricular Remodelingen_US
dc.subjectMyofibroblastsen_US
dc.subjectcytologyen_US
dc.subjectMatrix Metaloproteinaseen_US
dc.subjectTI Mappingen_US
dc.titleThe Relationship between Extracellular Volume Compartments and Matrix Metalloproteinases-2 in Left Ventricular Remodeling after Myocardial Infarctionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu