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    Advancing frailty assessment in dermatology: the role of the Clinical Frailty Scale and multidisciplinary collaboration
    (Oxford Univ Press, 2026) Altunisik, Nihal
    [No abstract available]
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    Assessing Public Awareness and Perception of Teledermatology Via Survey
    (Mattioli 1885, 2024) Altunisik, Nihal; Gencoglu, Sule; Turkmen, Dursun; Sener, Serpil
    Introduction:Teledermatology represents an alternative medical approach allowing for the remote assessment of a patient's clinical information without the need for face-to-face consultations. Objectives:This study aims to gauge the public's awareness and perception of teledermatology. Methods: This research employed a cross-sectional observational design. Data collection was executed using an online survey. Sociodemographic attributes of all participants, such as age, gender, and occupation, were recorded. The survey, designed using Google Forms, comprised two sections: demo-graphic information (5 questions) and queries related to teledermatology (10 questions). Questions and options in the survey were reviewed and revised by two dermatologists to eliminate potential misunderstandings, grammar, and other errors. Power analysis indicated a requirement of a minimum of 527 participants, given a 0.05 margin of error, 98% confidence level, and 0.50 response distribution. Results:A total of 873 individuals completed the survey- 47.7% were male and 52.3% were female. Students made up 48.1% of the participants, while 22.6% were civil servants. The Marmara Region had the highest participation rate at 47.7%. Remarkably, 41.9% of participants were unfamiliar with the term teledermatology. However, 57.2% expressed a preference for consultations via teleder-matology. Furthermore, 63.7% mentioned facing challenges when attempting to communicate with dermatologists for skin-related concerns. A notable 71.6% supported the formal implementation of teledermatology in our country. Conclusions:Our survey highlighted a limited awareness of teledermatology among participants, yet a majority showed a preference for teledermatology consultations. For a comprehensive understanding of public knowledge and perception towards teledermatology, more extensive, multicentric studies are necessary
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    Comment on 'A positive HIV result in a routine dermatology clinic systemics screening'
    (Oxford Univ Press, 2024) Toplu, Sibel Altunisik; Altunisik, Nihal
    We were intrigued by the correspondence of Baptista Gon & ccedil;alves et al., 'A positive HIV result in a routine dermatology clinic systemics screening', published recently in Clinical and Experimental Dermatology.
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    Comment on 'Dramatic improvement with colchicine in antihistamine- and omalizumab-resistant chronic spontaneous urticaria'
    (Oxford Univ Press, 2024) Altunisik, Nihal
    [No abstract available]
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    Comment on 'Effects of the COVID-19 pandemic on head lice and scabies infestation dynamics: a population-based study in France'
    (Wiley, 2022) Turkmen, Dursun; Altunisik, Nihal
    [Abstract Not Available]
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    Comment on 'Immune response to COVID-19 mRNA vaccination in patients with psoriasis undergoing treatment with biologics'
    (Oxford Univ Press, 2024) Toplu, Sibel Altunisik; Altunisik, Nihal
    [Abstract Not Available]
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    Comment on 'Modified intralesional aciclovir therapy in the management of recalcitrant palmoplantar and ungual warts: a case series of 14 patients'
    (Oxford Univ Press, 2025) Altunisik, Nihal; Kanat, Zekiye; Sezer, Suat; Turkmen, Dursun
    [No abstract available]
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    Comment on 'Psychodermatology in psychiatry: awareness and education among psychiatry trainees'
    (Wiley, 2022) Ucuz, Ilknur; Turkmen, Dursun; Altunisik, Nihal
    [Abstract Not Available]
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    Comment on 'Unexpected consequences of SARS-CoV-2 pandemic: scabies infestation'
    (Wiley, 2022) Turkmen, Dursun; Altunisik, Nihal
    [Abstract Not Available]
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    Commentary on Potential risk factors for Varicella-zoster virus reactivation after COVID-19 vaccination
    (Wiley, 2022) Turkmen, Dursun; Altunisik, Nihal; Altunisik Toplu, Sibel
    [Abstract Not Available]
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    Commentary on The effect of 577-nm pro-yellow laser on demodex density in patients with rosacea
    (Wiley, 2022) Altunisik, Nihal; Turkmen, Dursun
    [Abstract Not Available]
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    Comparison of patients' diagnoses in a dermatology outpatient clinic during the COVID-19 pandemic period and pre-pandemic period
    (Wiley, 2021) Turkmen, Dursun; Altunisik, Nihal; Mantar, Irem; Durmaz, Imge; Sener, Serpil; Colak, Cemil
    Aim In this study, we compared the current diagnoses of patients admitted to the dermatology outpatient clinic with the diagnoses during the non-pandemic period, and we examined the effect of COVID-19 on the patient profile. Methods Diagnoses were compared by examining the patient files of the 3-month period when the pandemic was influential in our country and the 2-week non-pandemic period corresponding to the same season a year ago. The outpatient diagnoses in the first month and the last month of the 3-month pandemic period were also compared. Results During the 3-month pandemic process, the most common reasons for applying to the outpatient clinic were acne, urticaria, psoriasis, and allergic/irritant contact dermatitis. Urticaria, psoriasis, allergic/irritant contact dermatitis, scabies, liken planus, mycosis fungoides, zona zoster, recurrent aphthous stomatitis and polymorph light eruption were statistically more common in the pandemic period. Moreover, acne, other eczematous dermatities, verruca, androgenic alopecia, and melanocytic nevus diagnoses were found to decrease statistically during the pandemic period when compared with the non-pandemic period. Conclusion Unlike other studies, the present study evaluated the patient diagnoses during the pandemic period and the period a year before and discussed the possible reasons for the changes in patient profiles.
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    Comparison of the dental serial patch test outcomes of lichen planus patients with and without oral involvement
    (Deri Zuhrevi Hastaliklar Dernegi, 2015) Altunisik, Nihal; Sener, Serpil; Sarac, Gulbahar Ceylan
    Background and Design: Lichen planus (LP) is a chronic and enflammatory cutaneous disease. Numereous diseases and agents have been accused in the etiology of LP. The materials used in dental treatment are one of these factors. We aimed to compare the results of dental series patch test in LP patients with and without oral involvement to determine whether the dental restorative materials play a role in the etiology of LP and to detect the effect of dental materials in cases where there is no oral involvement. Materials and Methods: The study involved a total of 38 patients who were admitted to the Dermatology Department and Dentistry Faculty Oral and Maxillofacial Surgery Department and were diagnosed with LP clinically and/or histopathologically. Nineteen of patients had oral involvement and the other 19 patients had no oral involvement. All of the patients received dental serial patch test. Results: Fourteen of the 19 patients with oral involvement (73.7%) and 15 patients without oral involvement (78.9%) showed positive reaction against at least one material. There was no statistically significant difference between the groups in terms of patch test positivity (p= 1.00). The allergens that mostly caused positive reaction against patch test in the group with oral involvement were copper sulfate and cobalt (II) cloride hexahydrate (23.3%). In the group without oral involvement the most common allergen that caused positive reaction was copper sulfate (% 47.3). Conclusion: The similarity of the allergens that caused positive reaction and the rate of positivity in dental serial patch test in the groups with and without oral involvement promote that the dental restorative materials may trigger the disease even in cases without oral LP. This study is a preliminary study due to the lack of a healthy control group and the small number of subjects.
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    Demodex parasite density in patients with melasma: a case-control study
    (Taylor & Francis Ltd, 2026) Baran, Fatma Bengisu; Altunisik, Nihal; Turkmen, Dursun; Kanat, Zekiye; Sener, Serpil
    Background: Although multiple factors contribute to the development of melasma, there are reports suggesting a potential role of Demodex parasites in hyperpigmentation. This study aimed to compare the density and prevalence of Demodex infestation between patients with melasma and healthy controls. Methods: This case-control study included 35 melasma patients and 35 healthy volunteers. Standard superficial skin biopsies using cyanoacrylate adhesive were taken from the malar regions. Samples were examined via light microscopy, with a density of >= 5 Demodex/cm(2) defined as positive. Results: No statistically significant difference was found between the melasma and control groups in terms of Demodex mite density or positivity rates. Correlation analysis revealed no significant relationship between mMASI scores and Demodex mite density. As a secondary finding, the mean mMASI score was significantly higher in male participants compared to female participants. Conclusion: In this case-control study, we found no statistically significant association between Demodex parasite density and melasma in our study population. While our findings do not support an association in this sample, future large-scale and multicenter studies could further explore the potential role of Demodex in skin disorders that have been suggested by other reports. The single-center design and moderate sample size should be considered when interpreting these results.
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    The efficacy of a single-session pro-yellow laser in the treatment of facial telangiectasia
    (Springer London Ltd, 2021) Turkmen, Dursun; Altunisik, Nihal; Sener, Serpil
    Facial telangiectasia (FT) is a condition in which small dilated vessels visibly protrude on the surface of the skin. The aim of this study was to evaluate the efficacy and safety of a single-session pro-yellow laser in the treatment of FT and spider angioma (SA) to compare it with a limited number of studies conducted on this subject. In this pilot study, we reviewed 41 patients who admitted to our dermatology clinic with FT and SA and were treated by using pro-yellow laser. The efficacy of the treatment was evaluated using the recorded clinical information and digital camera images. The improvement was graded as complete (90-100%), very good (75-89%), good (50-74%), moderate (25-49%), and weak (< 25%). Of the 41 patients included in the study, 37 (90.2%) had FT and four (9.8%) had SA. Twenty-two patients were female and 19 were male. Pro-yellow laser therapy was generally well tolerated by patients, and minimal pain occurred during the application. In 1-month follow-up, good, very good, or complete recovery was achieved in 51.4% of the FT patients. The new pro-yellow laser only has a yellow light wavelength. Its unique wavelength at 577-nm yellow light is ideal for vascular lesions. In this study, 51.4% of the patients with FT achieved good, very good, or complete improvement after a single session of 577-nm pro-yellow laser, and complete improvement was achieved in all the four patients with SA.
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    Evaluation of awareness regarding skin moisturisation and moisturiser usage frequency in individuals over 65 years of age
    (Wiley, 2020) Altunisik, Nihal; Kayhan Tetik, Burcu; Mete, Burak
    Objective Skin dryness is a common dermatological problem among older people.We aimed to evaluate the frequency of moisturiser use and awareness of its benefits among older people. Methods This cross-sectional descriptive study included 556 individuals over 65 years of age, all of whom were patients at family medicine and dermatology outpatient clinics at a tertiary teaching hospital. Data were summarised descriptively and analysed using binary logistic regression analysis. Results Of the 556 individuals who participated in the study, 241 were women and 315 were men. Moisturisers were being used by 217 patients (39%), and 91 patients (16.4%) classified the use of skin moisturisers as skincare. Conclusion We found that individuals over 65 years of age had insufficient knowledge regarding the use and benefits of skin moisturisers.
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    Evaluation of plasma zonulin level and its relationship with inflammatory cytokines in patients with vitiligo
    (Wiley, 2023) Arslan, Selami; Altunisik, Nihal; Turkmen, Dursun; Uremis, Muhammed M.; Sener, Serpil; Turkoz, Yusuf
    Background It has been proven that there is an increase in intestinal permeability in some autoimmune diseases. In our study, we purposed to assess intestinal permeability in vitiligo disease by looking at zonulin levels. At the same time, we aimed to examine the correlation of inflammatory cytokines and lipopolysaccharide (LPS) levels with zonulin. Methods Forty-one patients and 41 healthy participants were involved in our study. Blood samples were taken from all patients and controls, and the levels of zonulin, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and LPS were examined. Results The mean of zonulin in the patient group was found to be statistically higher than the control group (p < 0.05). A positive correlation was found between zonulin level and IL-6, TNF-alpha, and LPS levels (p < 0.05). TNF-alpha and LPS levels in the vitiligo group were significantly higher than in the control group, but there was no such significance in terms of IL-6 levels. Conclusion We think that serum zonulin level increases and intestinal permeability increases in vitiligo disease.
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    Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients
    (Wiley, 2022) Durmaz, Imge; Turkmen, Dursun; Altunisik, Nihal; Uremis, Nuray; Uremis, Muhammed Mehdi; Sener, Serpil; Turkoz, Yusuf
    Background Rosacea is a chronic inflammatory skin disease of unknown pathogenesis. TWEAK and TRAIL are two cytokines thought to have a role in the pathogenesis of some inflammatory and autoimmune diseases. Aims The purpose of this study was to examine TWEAK and TRAIL serum levels and oxidative stress markers in patients with rosacea. Material and Method Forty rosacea patients and 40 sex- and age-matched healthy controls were involved in the study. Serum TWEAK and TRAIL levels were evaluated with ELISA kits. Serum total antioxidant status, total oxidant status, total thiol, native thiol, disulfide levels were evaluated, and oxidative stress index was computed. Results Serum levels of TWEAK, TRAIL, and oxidative stress markers did not differ statistically in the patients and controls. Both TWEAK and TRAIL levels in the patients were detected to be statistically higher in male than in female. Conclusion TWEAK and TRAIL may not have a systemic effect in rosacea, unlike other inflammatory diseases. More studies are needed to investigate the role of TWEAK and TRAIL in rosacea.
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    Evaluation of temperament and character traits of patients with severe acne
    (Wiley, 2020) Altunisik, Nihal; Cansel, Neslihan; Turkmen, Dursun; Ucuz, Ilknur; Cumurcu, Hatice Birgul
    Background Acne vulgaris (AV) is an inflammatory disease of the pilosebaceous unit. The relationship between personality and acne development has not been fully explained, and to the best of our knowledge, there are a limited number of studies in the literature evaluating temperament and character traits of individuals with acne. Aim The aim of this study is to evaluate temperament-character traits of individuals with severe acne and to compare them with healthy controls. Patients/Methods This study was conducted on 51 patients who admitted to the dermatology outpatient clinic with complaint of acne and were diagnosed with severe AV and 47 healthy individuals, as a control group. All individuals included in the study participated voluntarily. The forms including sociodemographic data, clinical information, and Temperament and Character Inventory (TCI) scores were applied to the patient and control groups. Results The scores of scales/subscales of exploration (NS1), persistence (P), responsibility (S1), purposefulness (S2), resourcefulness (S3), self-acceptance (S4), enlightened 2nd nature (S5), self-directedness (S), integrated conscience (C5), and cooperativeness (C) were statistically significantly lower, and the scores of scales/subscales of worry and pessimism (HA1), fear of uncertainty (HA2), shyness (HA3), fatiguability (HA4), and harm avoidance (HA) were statistically significantly higher in the patient group, in comparison with the control group. Conclusions When we evaluated the patients with severe acne in terms of temperament and character features, we concluded that individuals' feeling of discomfort about their appearance may cause them to be less sociable, more anxious, and to have low resourcefulness and virtues.