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Öğe Adrenolökodistrofi: Tek voksel MR spektroskopi bulguları(Tanısal ve Girişimsel Radyoloji (Yeni Adı: Dİagnostic & Intervent. Radiol), 2004) Alkan, Alpay; Kutlu, Ramazan; Aslan, Mehmet; Yakıncı, CengizÖz: Adrenolökodistrofi (ALD), santral sinir sistemi ve adrenal kortekste çok uzun zincirli yağ asitlerinin birikimine bağlı olarak ortaya çıkan metabolik bir hastalıktır. Nöropatolojisinde serebral beyaz cevherde demyelinasyon, aksonal kayıp ve inflamasyonlu bölgelerde IgG ve sitokin birikimi bildirilmiştir [1-4]. Manyetik rezonans spektroskopi (MRS), değişik hastalıklarda hücresel düzeyde metabolit değişikliklerini gösterebilen bir görüntüleme yöntemidir [1,4-6]. Bu çalışmada, ALD’li bir olguda tutulum alanlarında ve normal görünen beyaz cevherde metabolit değişikliklerin olup olmadı ğının MRS ile ortaya konması amaçlanmıştır.Öğe Alkaptonuria with asymmetric otologic involvement: a case report(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2022) Ozturk, Ebru Ozer; Aslan, Mehmet; Marsak, Mucahit; Sezer, Suat[Abstract Not Available]Öğe Angiographic embolization in epistaxis: Our clinical experience and results(2021) Cicek, Mehmet Turan; Yildirim, İsmail Okan; Bayindir, Tuba; Sarac, Kaya; Tan, Mehmet; Aslan, Mehmet; Ozer Ozturk, EbruAim: Nosebleed, more commonly called epistaxis is a general clinical problem, and the most of bleedings can be treated non-invasive approach. However, because of persistent and sometimes life-threatening bleeding, additional treatment such as super-selective embolization may be required. In this study, we report our data on the endovascular treatment of persistent epistaxis. Materials and Methods: Between January 2010 and December 2019, all patients who were followed up at Inonu University Turgut Ozal Medical Center Otorhinolaryngology Clinic due to recurrent persistent nosebleed and required endovascular treatment were retrospectively screened. Demographic data, cause of epistaxis, localization of the bleeding, the clinical significance of the bleeding, interventional approach, complications related to treatment, and results were evaluated. Results: All of 18 patients with intractable epistaxis were included in the study. Depending on the etiology of epistaxis, patients were determined into three groups: idiopathic epistaxis (10/18), iatrogenic or traumatic epistaxis (7/18), and nasopharyngeal cancer (1/18). Nine of 18 patients required blood transfusions. The internal maxillary artery was embolized unilaterally in 12 of 18 (66%) and bilaterally in 2 of 18 (11%) procedures. Four patients were not embolized because of bleeding originated from ethmoidal branches of the ophthalmic artery. These four patients were operated on (endoscopic ethmoidectomy and bleeding control). Long-term success rates of embolization were 14 of 14. Major complications (transient hemiparesis) occurred in one patient after embolization. Conclusion: Endovascular approach proves to be effective for intractable and fatal epistaxis. Embolization has a good risk-benefit ratio in persistent bleeding. However, if bleeding is originated by the ethmoidal branches of the ophthalmic artery, embolization may not be performed to avoid visual complications.Öğe Angiographic embolization in epistaxis: Our clinical experience and results(2021) Cicek, Mehmet Turan; Yildirim, Ismail Okan; Bayindir, Tuba; Sarac, Kaya; Tan, Mehmet; Aslan, Mehmet; Ozer Ozturk, EbruAbstract: Aim: Nosebleed, more commonly called epistaxis is a general clinical problem, and the most of bleedings can be treated non-invasive approach. However, because of persistent and sometimes life-threatening bleeding, additional treatment such as super-selective embolization may be required. In this study, we report our data on the endovascular treatment of persistent epistaxis. Materials and Methods: Between January 2010 and December 2019, all patients who were followed up at Inonu University Turgut Ozal Medical Center Otorhinolaryngology Clinic due to recurrent persistent nosebleed and required endovascular treatment were retrospectively screened. Demographic data, cause of epistaxis, localization of the bleeding, the clinical significance of the bleeding, interventional approach, complications related to treatment, and results were evaluated. Results: All of 18 patients with intractable epistaxis were included in the study. Depending on the etiology of epistaxis, patients were determined into three groups: idiopathic epistaxis (10/18), iatrogenic or traumatic epistaxis (7/18), and nasopharyngeal cancer (1/18). Nine of 18 patients required blood transfusions. The internal maxillary artery was embolized unilaterally in 12 of 18 (66%) and bilaterally in 2 of 18 (11%) procedures. Four patients were not embolized because of bleeding originated from ethmoidal branches of the ophthalmic artery. These four patients were operated on (endoscopic ethmoidectomy and bleeding control). Long-term success rates of embolization were 14 of 14. Major complications (transient hemiparesis) occurred in one patient after embolization. Conclusion: Endovascular approach proves to be effective for intractable and fatal epistaxis. Embolization has a good risk-benefit ratio in persistent bleeding. However, if bleeding is originated by the ethmoidal branches of the ophthalmic artery, embolization may not be performed to avoid visual complications.Öğe Atlanto axial subluxation associated with rubinstein taybi syndrome(Eur J Radiol Extra, 2003) Sığırcı, Ahmet; Yakıncı, Mehmet Cengiz; Alkan, Alpay; Aslan, Mehmet; Sığırcı, Aykut; Kutlu, RamazanA case of atlanto-axial subluxation in a 5-year-old boy with Rubinstein /Taybi syndrome (RTS) is presented and the imaging findings are evaluated. To the best of our knowledge, atlanto-axial subluxation has not been reported in association with this syndromeÖğe Bir Yenidoğan Yoğun Bakım Ünitesinde Pnömotoraks Tanısıyla Yatan Hastaların Retrospektif Değerlendirilmesi(2013) Yakında, Hüseyin; Aslan, Mehmet; Kurnaz, Erdal; Gündüz, Ahmet; Özdemir, Ramazan; Karadağ, AhmetAmaç: Pnömotoraks yenidoğan döneminde solunum sıkıntısı yapan önemli nedenlerden biridir. Pnömotoraks genellikle mekanik ventilasyon tedavisi altında olan yenidoğanlarda görülür. Respiratuvar distres sendromu, mekonyum aspirasyonu sendromu ve doğum sonrası canlandırma işlemi uygulanması pnömotoraksa neden olabilir. Bu çalışmada yenidoğan yoğun bakım ünitemizde pnömotoraks nedeniyle yatırılan yenidoğanları geriye dönük olarak inceledik. Gereç ve Yöntemler: Yenidoğan yoğun bakım ünitemizde 2008-2011 yılları arasında pnömotoraks nedeniyle yatırılan 56 olgu geriye dönük olarak incelendi. Olguların demografik özellikleri, tanıları, tedavileri, yatış süreleri ve prognozları açısından değerlendirildi. Akciğer grafisi ile tanı konuldu. Olguların tedavisi göğüs tüpü drenajı ile yapıldı. İstatistiksel analiz için Pearson Ki Kare analizi ve Fisher'in Kesin Ki Kare analizi kullanıldı ve p<0,05 istatistiksel olarak anlamlı kabul edildi. Bulgular: Erkeklerde ve term bebeklerde pnömotoraks sıklığı yüksek bulundu. Çoğu olguda pnömotoraks gelişimi tek taraflı olup, yerleşimi sol taraftaydı. En sık görülen primer akciğer hastalığı respiratuvar distres sendromu olarak bulundu. Perinatal asfiksi en sık eşlik eden hastalıktı. Çalışmamızda 21 olguda pnömotoraks mekanik ventilasyon desteği sırasında görüldü. Olguların % 48,2'si kaybedildi. Çalışmamızda sürfaktan ihtiyacının olması, pnömotoraksın mekanik ventilasyon desteği altında gelişmiş olması, pnömotoraks bölgesi, ek hastalık varlığı ve doğumda resüsitasyon uygulanması ile mortalite arasında istatistiksel olarak anlamlı ilişki bulundu (p<0,05). Sonuç: Pnömotoraks morbidite ve mortalitesi yüksek olan, hayatı tehdit edici bir durumdur. Çalışmamızda mortalite oranının, sürfaktan ihtiyacı, mekanik ventilatör seyrinde pnömotoraks gelişmiş olması, ek hastalık varlığı, doğumda resüsitasyon uygulanması ve pnömotoraksın bilateral olması ile arttığı bulunmuşturÖğe Bir yenidoğan yoğun bakım ünitesinde pnömotoraks tanısıyla yatan hastaların retrospektif değerlendirilmesi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2013) Yakında, Hüseyin; Aslan, Mehmet; Kurnaz, Erdal; Gündüz, Ahmet; Özdemir, Ramazan; Karadağ, AhmetAmaç: Pnömotoraks yenidoğan döneminde solunum sıkıntısı yapan önemli nedenlerden biridir. Pnömotoraks genellikle mekanik ventilasyon tedavisi altında olan yenidoğanlarda görülür. Respiratuvar distres sendromu, mekonyum aspirasyonu sendromu ve doğum sonrası canlandırma işlemi uygulanması pnömotoraksa neden olabilir. Bu çalışmada yenidoğan yoğun bakım ünitemizde pnömotoraks nedeniyle yatırılan yenidoğanları geriye dönük olarak inceledik. Gereç ve Yöntemler: Yenidoğan yoğun bakım ünitemizde 2008-2011 yılları arasında pnömotoraks nedeniyle yatırılan 56 olgu geriye dönük olarak incelendi. Olguların demografik özellikleri, tanıları, tedavileri, yatış süreleri ve prognozları açısından değerlendirildi. Akciğer grafisi ile tanı konuldu. Olguların tedavisi göğüs tüpü drenajı ile yapıldı. İstatistiksel analiz için Pearson Ki Kare analizi ve Fisher’in Kesin Ki Kare analizi kullanıldı ve p<0,05 istatistiksel olarak anlamlı kabul edildi. Bulgular: Erkeklerde ve term bebeklerde pnömotoraks sıklığı yüksek bulundu. Çoğu olguda pnömotoraks gelişimi tek taraflı olup, yerleşimi sol taraftaydı. En sık görülen primer akciğer hastalığı respiratuvar distres sendromu olarak bulundu. Perinatal asfiksi en sık eşlik eden hastalıktı. Çalışmamızda 21 olguda pnömotoraks mekanik ventilasyon desteği sırasında görüldü. Olguların % 48,2’si kaybedildi. Çalışmamızda sürfaktan ihtiyacının olması, pnömotoraksın mekanik ventilasyon desteği altında gelişmiş olması, pnömotoraks bölgesi, ek hastalık varlığı ve doğumda resüsitasyon uygulanması ile mortalite arasında istatistiksel olarak anlamlı ilişki bulundu (p<0,05). Sonuç: Pnömotoraks morbidite ve mortalitesi yüksek olan, hayatı tehdit edici bir durumdur. Çalışmamızda mortalite oranının, sürfaktan ihtiyacı, mekanik ventilatör seyrinde pnömotoraks gelişmiş olması, ek hastalık varlığı, doğumda resüsitasyon uygulanması ve pnömotoraksın bilateral olması ile arttığı bulunmuştur.Öğe Bir Yenidoğan Yoğun Bakım Ünitesinde Pnömotoraks Tanısıyla Yatan Hastaların Retrospektif Değerlendirilmesi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2013) Yakında, Hüseyin; Aslan, Mehmet; Kurnaz, Erdal; Gündüz, Ahmet; Özdemir, Ramazan; Karadağ, AhmetAmaç: Pnömotoraks yenidoğan döneminde solunum sıkıntısı yapan önemli nedenlerden biridir. Pnömotoraks genellikle mekanik ventilasyon tedavisi altında olan yenidoğanlarda görülür. Respiratuvar distres sendromu, mekonyum aspirasyonu sendromu ve doğum sonrası canlandırma işlemi uygulanması pnömotoraksa neden olabilir. Bu çalışmada yenidoğan yoğun bakım ünitemizde pnömotoraks nedeniyle yatırılan yenidoğanları geriye dönük olarak inceledik. Gereç ve Yöntemler: Yenidoğan yoğun bakım ünitemizde 2008-2011 yılları arasında pnömotoraks nedeniyle yatırılan 56 olgu geriye dönük olarak incelendi. Olguların demografik özellikleri, tanıları, tedavileri, yatış süreleri ve prognozları açısından değerlendirildi. Akciğer grafisi ile tanı konuldu. Olguların tedavisi göğüs tüpü drenajı ile yapıldı. İstatistiksel analiz için Pearson Ki Kare analizi ve Fisher’in Kesin Ki Kare analizi kullanıldı ve p<0,05 istatistiksel olarak anlamlı kabul edildi. Bulgular: Erkeklerde ve term bebeklerde pnömotoraks sıklığı yüksek bulundu. Çoğu olguda pnömotoraks gelişimi tek taraflı olup, yerleşimi sol taraftaydı. En sık görülen primer akciğer hastalığı respiratuvar distres sendromu olarak bulundu. Perinatal asfiksi en sık eşlik eden hastalıktı. Çalışmamızda 21 olguda pnömotoraks mekanik ventilasyon desteği sırasında görüldü. Olguların % 48,2’si kaybedildi. Çalışmamızda sürfaktan ihtiyacının olması, pnömotoraksın mekanik ventilasyon desteği altında gelişmiş olması, pnömotoraks bölgesi, ek hastalık varlığı ve doğumda resüsitasyon uygulanması ile mortalite arasında istatistiksel olarak anlamlı ilişki bulundu (p<0,05). Sonuç: Pnömotoraks morbidite ve mortalitesi yüksek olan, hayatı tehdit edici bir durumdur. Çalışmamızda mortalite oranının, sürfaktan ihtiyacı, mekanik ventilatör seyrinde pnömotoraks gelişmiş olması, ek hastalık varlığı, doğumda resüsitasyon uygulanması ve pnömotoraksın bilateral olması ile arttığı bulunmuştur.Öğe Botulinum-A Toxin Application for the Treatment of Asymmetric Crying Facies(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2010) Aslan, Mehmet; Bıçak, Uğur; Gürlek, Ali; Üzüm, İsa; Yakıncı, Cengiz“Asimetrik ağlayan yüz” istirahat esnasında simetrik olan yüzün, ağlama ya da gülme sırasında ağız köşesinin aşağı ve dışa hareketinin kısıtlı olması ya da hiç olmamasıdır. Asimetrinin etiyolojisinde tek taraflı depresör anguli oris kasının konjenital yokluğu veya hipoplazisi vardır. Major konjenital anomalilerle, en çok da kardiovasküler sistemle birlikteliği bildirilmiştir. Bu yazıda asimetrik ağlayan yüzü olan 6 yaşındaki bir erkek çocuğu ve botulinum-A toksiniyle (BOTOKS) tedavisi sunulmaktadır. Asimetrik ağlayan yüzün BOTOKS’la tedavisi henüz bildirilmemiştir.Öğe Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus(Neuroradiology, 2005) Saraç, Kaya; Akıncı, Ayşehan; Alkan, Alpay; Aslan, Mehmet; Baysal, Tamer; Özcan, AbdulcemalAbstract The metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9±3.4 (8.2–19.4). The average number of keto-acidosis episodes was 1.9±2.2 (0–9) and the average number of daily insulin injections was 2.8±0.97 (2–4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover.Öğe Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type1 diabetes mellitus(NEURORADIOLOGY, 2005) Saraç, Kaya; Akıncı, Ayşehan; Alkan, Alpay; Aslan, Mehmet; Baysal, Tamer; Özcan, AbdulcemalThe metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9±3.4 (8.2–19.4). The average number of keto-acidosis episodes was 1.9±2.2 (0–9) and the average number of daily insulin injections was 2.8±0.97 (2–4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover.Öğe Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications(Eur J Radiol, 2004) Alkan, Alpay; Kutlu, Ramazan; Koçak, Gülendam; Sığırcı, Ahmet; Emul, Murat; Doğan, Selda; Aslan, Mehmet; Saraç, Kaya; Yakıncı, Mehmet CengizPurpose: To investigate whether there are metabolite changes in basal ganglia of children with complete healing of rheumatic fever (RF), history of Syndenham chorea (SC) and obsessive compulsive-tic disorder (OCTD) developed after RF when compared with healthy controls and each other. Material and methods: A total of 49 children with history of RF and 31 healthy controls were included into the study. All patients and control group underwent a detailed neuropsychiatric evaluation. Children with the history of RF were classified into three groups as; group 1: with history of RF without neuropsychiatric complications (NCRF), group 2: only with history of SC (HSC), group 3: with HSC and OCTD (OCTD). After MR imaging, single voxel MR spectroscopy was performed in all subjects. Voxels (15 × 15 × 15 mm) were placed in basal ganglia. N-acetyl aspartate (NAA)/creatin (Cr), and choline (Cho)/Cr ratios were calculated. Results: OCTD were detected in 13 children with HSC. NAA/Cr ratio was found to be decreased in these children when compared with NCRF (n:29), HSC without OCTD (n:7) and control groups (n:31). No significant difference was found in metabolite ratios of children with HSC without OCTD when compared with NCRF and control groups. There were no significant differences in Cho/Cr ratio between patient and control groups. Conclusion: Although MR imaging findings was normal, MR spectroscopy findings (decreased NAA/Cr ratio) in our study support the neuronal loss in basal ganglia of children with OCTD and could indicate the development of permanent damage.Öğe Can isolated sudden sensorineural hearing loss (SSNHL) and idiopathic acute facial paralysis (Bell's palsy) be symptoms of COVID-19?(W B Saunders Co-Elsevier Inc, 2021) Aslan, Mehmet; Cicek, Mehmet TuranObjectives: The symptoms of COVID-19 at the time of presentation mainly include fever, cough, respiratory distress and myalgia. On the other hand, as neurological symptoms, disruption of taste and smell and cerebrovascular pathologies are well-known, whereas other neurological symptoms and signs are being newly recognized. Sudden-onset sensorineural hearing loss (SSNHL) and idiopathic acute facial paralysis (Bell's palsy) are otologic emergencies that are frequently encountered by otorhinolaryngology specialists. Although there are many articles describing SSNHL and Bell's palsy in the literature, the literature describing their relationship to COVID-19 is limited. In our study, we aimed to present the neuro-otologic relationship of SSNHL and Bell's palsy with COVID-19. Material and methods: The pretreatment real-time oronasopharyngeal PCR tests, COVID-19 symptomatology and COVID-19 infection statuses of patients who presented to our clinic with isolated SSNHL and Bell's palsy between April 2020 and April 2021 were questioned, and the data of the patients were collected. Throughout their treatment, the patients were followed-up in terms of COVID-19 infection. This is a prospective study. Moreover, to observe the change in the incidence, the data of patients visiting between January 2019 and January 2020 were also collected. The data of the patients were statistically analyzed using SPSS. Results: The study included a total of 177 patients. The SSNHL group consisted of 91 patients, and the Bell's palsy group consisted of 86 patients. Neither group showed a statistically significant difference in comparison to the year without the pandemic in terms of the patient numbers (incidence), sex, age, morbidity, response to treatment or social habits. There was a statistically significant difference in age only in the Bell's palsy group, but this difference was not medically significant. Conclusion: As a result of our study, we did not observe a relationship between COVID-19 and cases of SSNHL and Bell's palsy. It is recommended to apply standard otologic treatment to isolated SSNHL and Bell's palsy patients whose association with COVID-19 is not determined.Öğe Changes in homocysteine levels in epileptic children receiving sodium valproate(Erciyes Tıp Dergisi, 2003) Özerol, Elif; Özerol, İbrahim; Aslan, Mehmet; Yakıncı, Cengiz; Temel, İsmailÖz: Amaç: Valproatın folat ve homosistein düzeyleri üzerinde etkileri ile ilgili veriler çelişkilidir. Bu çalışmanın amacı valproat alan çocuklarda homosistein, folat ve vitamin B12 düzeylerinde farklılık olup olmadığını değerlendirmektir. Hastalar ve Yöntem: Sodyum valproat alan altmışbeş hasta ve yirmibeş sağlıklı kontrol çalışıldı. Serum total homosistein düzeyleri ELİZA kitiyle analiz edildi. Vitamin B12 and folat değerleri BIo DPC kitleriyle ölçüldü. Bulgular: Serum Hey konsantrasyonları hastalarda kontrollerdekinden anlamlı olarak daha yüksekti. Üstelik, kontrollerle karşılaştırıldığında serum folat düzeylerinin hastalarda anlamlı olarak azaldığı gözlendi. Bunun aksine, serum vitamin B12 düzeyleri değişmedi. Sonuç: Sonuçta, bizim verilerimiz valproat ile uzun süre tedavinin serum homosistein konsantrasyonlarını arttırdığım göstermektedir; homosistein metabolizması üzerinde valproatın indükleyici bir etkisi olabilir ve bu etki düşük folat düzeylerinden bağımsız değildir. Bu sonuçlar sodium valproat alan. hastalarda hiperhomosisteineminin tanımlanması için. homosistein düzeylerinin tayin edilmesi gerektiğini göstermektedir. Başlık (İngilizce): Sodyum valproat alan epileptik çocuklarda homosistein düzeylerindeki değişiklikler Öz (İngilizce): Purpose: The data regarding valproate and their influence on folate and homocysteine levels are conflicting. The aim of this study was to evaluate whether differences exist in homocysteine, folate, and vitamin Bn levels in children receiving valproate. Patients and Methods: Sixty-five patients receiving sodium valproate and twenty-five healthy controls were included in the study. Serum total homocysteine levels were analyzed by enzyme linked immunosorbent assay kit. Vitamin Bi2 and folate values were measured by Bio DPC kits. Results: Serum homocysteine concentrations were significantly higher in patients than those of the controls. Moreover, serum folate levels were observed to be significantly decreased in patients compared to controls. On the contrary, serum vitamin B12 levels did not change in the patients. Conclusion: Our data show that prolonged treatment with valproate increases serum homocysteine concentrations suggesting that an effect of inducer valproate on homocysteine metabolism could exist, which is not independent of the effect of low folate levels. These results indicate that homocysteine levels should be determined in order to identify hyperhomocysteinemia among patients receiving sodium valproate.Öğe A comparative analysis of long-term life qualities of head and neck cancer (nasopharyngeal, hypopharyngeal and laryngeal cancers) patients who were treated with the intensity-modulated radiation therapy (IMRT): Expectations and outcomes(2021) Aslan, Mehmet; Çiçek, Mehmet TuranThe long-term quality of life outcomes of head-neck cancer patients who were treated with Intensity-modulated radiation therapy (IMRT) are not well known. The aim of this study was to determine the long-term quality of life and problems in patients undergoing IMRT in head-neck cancers. The study was conducted at a high-volume tertiary care setting. Patients who have received IMRT for head and neck cancers in our clinic, who completed at least one year following the completion of their therapy, and who are being followed up for the present, were included in the study. To assess patients’ quality of life and problems they experience, the updated(revised) version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC QLQ-H&N43) and The Arizona Sexual Experience Scale (ASEX) were administered to patients by the same clinician, using the face-to-face interview method. The study included 18,28,30 patients who received IMRT for hypopharyngeal, nasopharyngeal, and laryngeal cancer, respectively. Given the EORTC QLQ-H&N43 results of patient groups; contrary to expectations, mucosal dryness, sense and voice problems were observed as common problems in all patient groups. Thanks to protection of body integrity, good social contact and communication, a high level of satisfaction was observed in all patient groups. In conclusion; a high level of satisfaction was observed in patient groups treated with IMRT, despite long-term mucosal dryness, voice disturbances and sense problems, thanks to the preservation of body integrity and good social communication.Öğe Comparison of brain apparent diffusion coefficient value in naturally and assisted conceived newborns(Taylor & Francis Ltd, 2012) Aslan, Mehmet; Dogan, Metin; Celik, Onder; Karsavuran, Nazan; Dogan, Derya Gumus; Botan, Edin; Alkan, AlpayBackground: Our aim was to assess the value of brain apparent diffusion coefficient (ADC) in Intra Cytoplasmic Sperm Injection (ICSI) and spontaneously conceived preterm singletons. Methods: Twenty ICSI-conceived preterm singletons and 20 gestational age matched spontaneously conceived preterm singletons were studied. All subjects underwent diffusion-weighted imaging (DWI). The main outcome measure was the brain ADC value in the in ICSI-conceived and naturally conceived newborns. Results: Children born after ICSI had an increased ADC value than the controls. The ADC values of ICSI-conceived singletons were higher than those of spontaneously conceived singletons at cerebellum, corpus striatum, frontal lobe, occipital lobe, and temporal lobe white matter. The mean Apgar score, birth weight, height, and head circumference of ICSI children were found to be similar to naturally conceived children. Conclusions: Measuring ADC value may be a promising marker in identifying neurological outcome of ICSI-conceived newborns.Öğe A comparison of the platelet index, neutrophil-lymphocyteand platelet-lymphocyte ratios of patients withdifferentiated thyroid cancer and nodular hyperplasia(2021) Aslan, Mehmet; Çiçek, Mehmet TuranAim: In our study, it was aimed to determine the usability of the inexpensive, fast and easily accessible platelet index, NLR (Neutrophil to Lymphocyte ratio) and PLR (Platelet to Lymphocyte ratio) as predictive values in patients with differentiated thyroid cancer and nodular hyperplasia. Materials and Methods: The data of 454 patients operated due to differentiated thyroid cancers and nodular hyperplasia at our clinic between 2010 and 2020 and a control group consisting of 120 healthy individuals were retrospectively examined. The data of the patients and the control group were statistically analyzed. Results: The study included a total of 574 participants including 314 patients who received differentiated thyroid cancer surgery, 140 patients who received surgery due to thyroid nodular hyperplasia and a control group consisting of 120 healthy individuals. There was no significant difference among the groups in terms of age. There was a dominance of the female sex among the groups, but the difference was insignificant. There was no significant difference among the groups in terms of their MPV, PLR or NLR values. However, the PDW (Platelet Distribution Width) values were significantly higher among the differentiated thyroid cancer patients.Conclusion: In our study, we observed that the MPV, PLR and NLR values varied, but the differences were not statistically significant. The PDW values were significantly high. Considering the current literature, we concluded that, among the existing parameters, NLR is a more reliable constant value at the stage of diagnosis.Öğe Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus(Springer, 2012) Aslan, Mehmet; Celik, Onder; Celik, Nilufer; Turkcuoglu, Ilgin; Yilmaz, Ercan; Karaer, Abdullah; Simsek, YavuzTo assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 +/- A 8.3 vs. 9.6 +/- A 5.9 ng/ml, P = 0.001) and nesfatin-1 levels were found lower (5.5 +/- A 8.1 vs. 8.1 +/- A 23.9 ng/ml, P = 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 +/- A 4.3 and 8.2 +/- A 1.9 ng/ml, P = 0.618) and nesfatin-1 levels (5.4 +/- A 4.0 and 6.2 +/- A 10.3 ng/ml, P = 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM.Öğe Covid-19 Tanı,Triaj ve Patogenez(İnönü Üniversitesi Tıp Fakültesi, 2020) Oğuzalp, S. Şeyma; Aslan, MehmetGİRİŞ: Koronavirüsler (CoV), soğuk algınlığı gibi toplumda yaygın görülen, kendi kendini sınırlayan hafif enfeksiyon tablolarından, Orta Doğu Solunum Sendromu (Middle East Respiratory Syndrome, MERS) ve Ağır Akut Solunum Sendromu (Severe Acute Respiratory Syndrome, SARS) gibi daha ciddi enfeksiyon tablolarına neden olabilen büyük bir virüs ailesidir.Öğe Delayed myelination in a rhizomelic chondrodysplasia punctata case MR spectroscopy findings(Magn Reson Imaging, 2003) Alkan, Alpay; Kutlu, Ramazan; Yakıncı, Mehmet Cengiz; Sığırcı, Ahmet; Aslan, Mehmet; Saraç, KayaRhizomelic chondrodysplasia punctata is a member of genetic peroxisomal disorders. Delayed myelination, which is probably related to the inadequacy of plasmalogens biosynthesis, is an important feature of this disorder. Direct assessment of neuropathologic aspects of RCDP syndrome such as neuronal degeneration and delayed myelination is possible with MR spectroscopy. In this report, MR spectroscopy findings (decreased Cho/Cr and increased Ins-Gly/Cr ratios and increased levels of mobile lipids) of a rhizomelic chondrodysplasia punctata case supporting delayed myelination are presented. This is the second report of MR spectroscopy examination of the specific brain metabolic changes associated with rhizomelic chondrodysplasia punctata. © 2003 Elsevier Science Inc. All rights reserved.
