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  • Küçük Resim Yok
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    The effects of recombinant human bone morphogenic protein-2 and low-level laser irradiation on synthetic graft healing in a rat bony defect model
    (E-Century Publishing Corp, 2016) Koparal, Mahmut; Kose, Ibrahim; Atalay, Yusuf; Cakmak, Omer; Alan, Hilal; Agacayak, Kamil Serkan; Erdogdu, Ibrahim Halil
    We assessed the benefit of bone morphogenic protein-2 (BMP-2) and low-level laser irradiation (LLLI) on the osseointegration of synthetic bone grafts. Synthetic bone grafts are safe alternatives to autografts. BMP-2 and LLLI have been shown separately to improve bone healing. However, their effects have not been evaluated together with synthetic materials. Here, we used a rat model to compare the efficacy of BMP-2 and LLLI on synthetic graft healing. Male Sprague-Dawley rats (n = 35) were divided equally into groups: control (defect only), graft only, graft and BMP-2, graft and LLLI, and a combination of graft, LLLI, and BMP-2. A 3 x 3 mm monocortical tibial defect was filled using a synthetic graft with or without 2 mg/mL BMP-2 pre-treatment. LLLI was performed using an optical fibre and an indium-gallium-arsenide-phosphate laser for 60 s daily for 7 days, delivering 6.0 J/day. Histopathology was performed 4 weeks post-graft using a standardised scoring system (1-5, based on the degree of healing observed). Groups were compared using the MannWhitney U test, with p values < 0.05 considered significant. Osteogenesis was poor in both the control and graft-only groups (1.4 +/- 0.5 and 2.3 +/- 0.5, respectively). BMP-2-(4.3 +/- 0.5), LLLI-(3.7 +/- 0.5), and BMP-2/LLLI-treated (4.7 +/- 0.5) grafts all displayed significantly more healing than the control or graft alone groups (P < 0.001). Both BMP-2 and LLLI significantly improved the osseointegration of synthetic bone grafts. However, no synergy was noted between the therapies.
  • Küçük Resim
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    The investigation of effects of proton pump inhibitors
    (2018) Asutay, Fatih; Atalay, Yusuf; Acar, Ahmet Huseyin
    Aim: Proton pump inhibitors (PPI) have been widely used throughout the world. The effects of the PPIs on bone mineral density (BMD) is important for oral surgeons. The aim of this study was evaluate alterations in bone mineral density in patients using PPI. Material and Methods: A total of 92 patients were enrolled in the study and were separated into 4 groups (24 in control group, 22 in Lansoprazole group, 24 in Pantoprazole group and 22 in Esomeprazole group). Hounsfield Unit scores were measuredseparately of the incisor, canine, premolar, molar and tubule regions in the jaws with computed tomography. The measurement area in the dental regions was defined as an area of 2mm2 at least 2mm from the apex of the teeth. All data were collected and statistically analysed. Results: There was no significant difference between the groups in respect of mean age. There were no significant differences between the control and the study groups. Also no significant difference was found among the study groups. Conclusion: These data revealed that there were no correlations between decreased maxillary bone mineral density and proton pump inhibitor use. Further studies with more extensive samples should take into consideration drug doses and the period of use.