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Öğe Diaphragmatic injuries due to stab wounds: Analysis of 18 patients(Turkish Surgical Society, 2010) Dirican A.; Ateş M.; Ünal B.; Yilmaz M.; Özgör D.; Yilmaz S.Purpose: Although all diaphragmatic injuries caused by stab wounds need to be repaired, preoperative diagnosis is often difficult. The purpose of the present study is to share our experience regarding diaphragmatic wounds. Patients and Methods: Eighteen patients with stab wounds causing diaphragmatic injuries treated at General Surgery Clinic of ?nönü University Faculty of Medicine between March 2000 and June 2009 were evaluated retrospectively. Results: There were 15 male and 3 female patients with mean age of 33 (20-69) years. Most common complaints were difficulty in breathing, and abdominal and chest pain. Localization of the injury was on the left side of the diaphragm in 11 (61%) patients and on the right side in 6 (33%) patients, and one (6%) patient had injuries on both sides. Surgery was performed in 17 patients with midline abdominal incision within the first 24 hours after the injury and with lateral thoracotomy in a patient 10 days after injury. Mortality occurred in 3 (17%) patients; in 2 patients due to bleeding from accompanying injuries and in one patient due to postoperative sepsis. Conclusion: Preoperative diagnosis of diaphragmatic injury due to a stab wound is difficult. These patients highly probably have visceral organ injuries in addition to diaphragmatic injuries. Diaphragmatic injuries should be kept in mind in patients with abdominal penetrating stab injuries which are located between umbilicus and xiphoid. Both hemidiaphragms should be explored carefully during abdominal surgery of these patients.Öğe Interaction of Statins with Grapefruit Juice(Society of Pharmaceutical Sciences of Ankara (FABAD), 2023) Ateş M.; Sahin S.Grapefruit juice, which discovered to interact with felodipine for the first time, is now known to interact with more than 80 drugs. Statins are among the drugs that interact with grapefruit juice. Grapefruit juice-statin interactions were first investigated in 1998 in human pharmacokinetic studies with lovastatin and simvastatin. The pharmacokinetic and pharmacodynamic basis of the interaction has been extensively investigated in studies. Flavonoids and furanocoumarins, the main components of grapefruit juice, have been reported to cause drug interactions. Furthermore, statin-grapefruit juice interactions occur mostly through inhibition of cytochrome-3A4 (CYP3A4), to a lesser extent through inhibition of P-glycoprotein (Pgp) and organic anion transporting polypeptides (OATPs). Changes in plasma drug levels as a result of interaction may increase the side-effect of statins or reduce their therapeutic efficacy. Therefore, patients using statins are generally advised to avoid grapefruit juice consumption. © 2023 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.Öğe Permeability enhancers used to increase intestinal absorption(Hacettepe University, Faculty of Pharmacy, 2013) Ateş M.; Kaynak M.S.; Şahin S.Drugs are administered through various routes to obtain systemic effect. Of these, the most commonly used route of administration is the oral route. Following oral administration, the drug has to pass through several biological membranes until it reaches the site of effect. The most important one among these membranes is the intestinal epithelium. Absorption through the intestinal epithelium occurs mainly by two mechanisms. These mechanisms are absorption through the epithelial cell membranes (transcellular route) and absorption through the tight junctions between epithelial cells. Transport of molecules through the tight junctions is called as paracellular (intercellular) transport. The most effective way to improve drug absorption by regulating paracellular permeability is the structural organization of tight junctions. It is reported that some substances such as polymers, surfactants increase the absorption of paracellulary transported drugs across membranes by means of various mechanisms. These substances are also known as permeation enhancers. In this review, physicochemical peroperties of permeability enhancers and their mechanism of effect to increase intestinal absorption were discussed. Also various examples were given for these permeability enhancers and the studies counducted using these substances were evaluated. © 2013, Hacettepe University, Faculty of Pharmacy. All rights reserved.Öğe Simultaneous determination of acyclovir, metoprolol and phenol red by a RP-HPLC method for intestinal perfusion studies(Hacettepe University, Faculty of Pharmacy, 2015) Ateş M.; Kaynak M.S.; Şahin S.Intestinal perfusion (SPIP) technique is one of the most commonly used techniques to determine the intestinal permeability of a drug. In perfusion studies, metoprolol (as tartrate) and phenol red are widely used as a refer- ence compounds to evaluate the permeability coefficient of the compound of interest (acyclovir in this study). The aim of our study was to develop and validate a reversed-phase liquid chromatographic method for the simultan- eous determination of acyclovir, metoprolol and phenol red for use in intes- tinal perfusion studies. The analysis was performed on a C18 column (4.6 mm x 250 mm, 5 ?m) using a mobile phase consisting of methanol:0.0125 M potassium dihydrogen phosphate buffer (55:45, v/v; pH 7.0). Method was validated according to the FDA guidelines for selectivity, sensitivity, linearity, precision, accuracy, stability. All calibration curves were linear (r2> 0.999). Lower limit of quantitation was 0.04 ?g/mL for acyclovir, 0.02 ?g/mL for metoprolol, 0.01 ?g/mL for phenol red. Detection limit was 0.01 ?g/mL for acyclovir 0.002 ?g/mL for metoprolol, 0.003 ?g/mL for phenol red. Precision and accuracy results of the method fulfilled the required limits. This newly developed and validated method can be readily used on a routine basis for the standardization of in situ intestinal permeability experiments. © 2015, Hacettepe University, Faculty of Pharmacy. All rights reserved.
