Interaction of Statins with Grapefruit Juice
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Society of Pharmaceutical Sciences of Ankara (FABAD)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Grapefruit juice, which discovered to interact with felodipine for the first time, is now known to interact with more than 80 drugs. Statins are among the drugs that interact with grapefruit juice. Grapefruit juice-statin interactions were first investigated in 1998 in human pharmacokinetic studies with lovastatin and simvastatin. The pharmacokinetic and pharmacodynamic basis of the interaction has been extensively investigated in studies. Flavonoids and furanocoumarins, the main components of grapefruit juice, have been reported to cause drug interactions. Furthermore, statin-grapefruit juice interactions occur mostly through inhibition of cytochrome-3A4 (CYP3A4), to a lesser extent through inhibition of P-glycoprotein (Pgp) and organic anion transporting polypeptides (OATPs). Changes in plasma drug levels as a result of interaction may increase the side-effect of statins or reduce their therapeutic efficacy. Therefore, patients using statins are generally advised to avoid grapefruit juice consumption. © 2023 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
Açıklama
Anahtar Kelimeler
CYP3A4, drug interaction, Grapefruit juice, OATP, P-gp, statins
Kaynak
Fabad Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
48
Sayı
2
