Interaction of Statins with Grapefruit Juice

Basit Öğe Kaydı
dc.authorscopusid56960016500
dc.authorscopusid57221923900
dc.contributor.authorAteş M.
dc.contributor.authorSahin S.
dc.date.accessioned2024-08-04T20:01:01Z
dc.date.available2024-08-04T20:01:01Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractGrapefruit juice, which discovered to interact with felodipine for the first time, is now known to interact with more than 80 drugs. Statins are among the drugs that interact with grapefruit juice. Grapefruit juice-statin interactions were first investigated in 1998 in human pharmacokinetic studies with lovastatin and simvastatin. The pharmacokinetic and pharmacodynamic basis of the interaction has been extensively investigated in studies. Flavonoids and furanocoumarins, the main components of grapefruit juice, have been reported to cause drug interactions. Furthermore, statin-grapefruit juice interactions occur mostly through inhibition of cytochrome-3A4 (CYP3A4), to a lesser extent through inhibition of P-glycoprotein (Pgp) and organic anion transporting polypeptides (OATPs). Changes in plasma drug levels as a result of interaction may increase the side-effect of statins or reduce their therapeutic efficacy. Therefore, patients using statins are generally advised to avoid grapefruit juice consumption. © 2023 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.en_US
dc.identifier.doi10.55262/fabadeczacilik.1187441
dc.identifier.endpage358en_US
dc.identifier.issn1300-4182
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85169565385en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage337en_US
dc.identifier.trdizinid1192797en_US
dc.identifier.urihttps://doi.org/10.55262/fabadeczacilik.1187441
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1192797
dc.identifier.urihttps://hdl.handle.net/11616/91192
dc.identifier.volume48en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)en_US
dc.relation.ispartofFabad Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCYP3A4en_US
dc.subjectdrug interactionen_US
dc.subjectGrapefruit juiceen_US
dc.subjectOATPen_US
dc.subjectP-gpen_US
dc.subjectstatinsen_US
dc.titleInteraction of Statins with Grapefruit Juiceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu