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    Analysis of peripheral blood lymphocyte phenotypes and Th1 Th2 cytokines profile in the systemic immune responses ofHelicobacter pylori infected individuals
    (Microbiology and Immunology, 2008) Kayhan, Başak; Araslı, Mehmet; Eren, Hacı; Aydemir, Selim; Aktaş, Elif
    H. pylori elicits specific humoral and cellularimmune responsesin themucosalimmune system.However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While αβ TCR+ lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan γδ TCR+ lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed.