Analysis of peripheral blood lymphocyte phenotypes and Th1 Th2 cytokines profile in the systemic immune responses ofHelicobacter pylori infected individuals
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Microbiology and Immunology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
H. pylori elicits specific humoral and cellularimmune responsesin themucosalimmune system.However,
the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori
positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based
cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls.
While αβ TCR+ lymphocytes and their phenotype analysis were not significantly different to those of
healthy controls, the percentage of pan γδ TCR+ lymphocytes was up to 2.4 times greater in the H. pylori
positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in
serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2
type immune response. The correlation between phenotype and type of T cell response in the peripheral
blood during H. pylori infection is discussed.
Açıklama
Anahtar Kelimeler
Cytokines, Gamma delta T cells, Helicobacter pylori, Immunophenotyping
Kaynak
Microbiology and Immunology
WoS Q Değeri
Scopus Q Değeri
Cilt
52
Sayı
11
Künye
Kayhan, B. Araslı, M. Eren, H. Aydemir, S. Aktaş, E. (2008). Analysis of peripheral blood lymphocyte phenotypes and Th1 Th2 cytokines profile in the systemic immune responses ofHelicobacter pylori infected individuals. Microbiology and Immunology . 52(11), 531–538.
