Analysis of peripheral blood lymphocyte phenotypes and Th1 Th2 cytokines profile in the systemic immune responses ofHelicobacter pylori infected individuals
| dc.authorid | 41809 | en_US |
| dc.contributor.author | Kayhan, Başak | |
| dc.contributor.author | Araslı, Mehmet | |
| dc.contributor.author | Eren, Hacı | |
| dc.contributor.author | Aydemir, Selim | |
| dc.contributor.author | Aktaş, Elif | |
| dc.date.accessioned | 2017-08-03T11:11:57Z | |
| dc.date.available | 2017-08-03T11:11:57Z | |
| dc.date.issued | 2008 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | H. pylori elicits specific humoral and cellularimmune responsesin themucosalimmune system.However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While αβ TCR+ lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan γδ TCR+ lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed. | en_US |
| dc.identifier.citation | Kayhan, B. Araslı, M. Eren, H. Aydemir, S. Aktaş, E. (2008). Analysis of peripheral blood lymphocyte phenotypes and Th1 Th2 cytokines profile in the systemic immune responses ofHelicobacter pylori infected individuals. Microbiology and Immunology . 52(11), 531–538. | en_US |
| dc.identifier.doi | 10.1111/j.1348-0421.2008.00066.x | en_US |
| dc.identifier.endpage | 538 | en_US |
| dc.identifier.issn | 03855600 | |
| dc.identifier.issue | 11 | en_US |
| dc.identifier.startpage | 531 | en_US |
| dc.identifier.uri | http://doi.wiley.com/10.1111/j.1348-0421.2008.00066.x | |
| dc.identifier.uri | https://hdl.handle.net/11616/7435 | |
| dc.identifier.volume | 52 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Microbiology and Immunology | en_US |
| dc.relation.ispartof | Microbiology and Immunology | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Cytokines | en_US |
| dc.subject | Gamma delta T cells | en_US |
| dc.subject | Helicobacter pylori | en_US |
| dc.subject | Immunophenotyping | en_US |
| dc.title | Analysis of peripheral blood lymphocyte phenotypes and Th1 Th2 cytokines profile in the systemic immune responses ofHelicobacter pylori infected individuals | en_US |
| dc.type | Article | en_US |
