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Öğe Cystic Adrenal Lymphangioma - Report of two cases and review of the literature(Pakistan Medical Assoc, 2012) Cakir, Ebru; Aydin, N. Engin; Samdanci, Emine; Ates, Mustafa; Elmali, Candan; Sayin, Sadegul; Erdem, GulnurCystic adrenal lymphangiomas are very rare, benign vascular lesions. They are usually found during a work up for abdominal pain or incidentally during imaging studies for an unrelated cause. We report two cases of cystic adrenal lymphangiomas. They presented with flank discomfort, hypertension and flushing. Their laboratory findings were in normal limits. Radio logic imagings showed adrenal cystic neoplasm and the patients underwent adrenelectomy. Histopathologic examination and immunohistochemical findings were consistent with lymphangioma. Cystic lymphangiomas may imitate other adrenal neoplasms and must be kept in mind in the clinical and radiologic differential diagnosis of cystic adrenal lesions.Öğe Effects of highly purified urinary FSH and human menopausal FSH on uterine myoelectrical dynamics(Oxford Univ Press, 2010) Hascalik, Seyma; Celik, Onder; Tagluk, M. Emin; Yildirim, Ayse; Aydin, N. EnginThe aim of the study was to investigate the effects of urinary follicle-stimulating hormone (FSH) compounds on the electrical activity of myometrium using signal-processing techniques. Thirty animals were involved in the experiment. After two successive normal estrous cycles, 15 of these animals were put into three equal subgroups. Group 1 was the control; animals were given solvent. Groups 2 and 3 were treated with Urofollitropin and Menotropin, respectively. The other 15 animals were ovariectomized and subjected to the same protocol. Their uterine myoelectrical signals were recorded over a period of at least 3 min at a sampling frequency of 500 Hz, and analyzed through software assisted signal processing. The results show the power and some characteristic spectral components of myoelectrical signal were differentially reduced with the administration of highly purified urinary FSH and human menopausal FSH but significant differences were not detected between their histology. In conclusion, uterine myoelectrical signals change with administration of urinary FSH preparations. Human menopausal FSH and more precisely highly purified FSH suppress the spectral components and modify the power of the myoelectrical signals which provides uterine quiescence.Öğe Enhanced endometrial response to a magnetic intrauterine device: A preliminary study(Taylor & Francis Ltd, 2009) Celik, Onder; Ugras, Murat; Hascalik, Seyma; Aydin, N. Engin; Abbasov, TeymurazObjective To evaluate the effects of an intrauterine device producing a static magnetic field on the endometrial histology of rats. Methods The experiments involved 20 adult female Wistar albino rats that were divided into five groups. Group 1 was sham-operated; Groups 2, 3 and 4 had a copper intrauterine device (IUD), an uncovered intrauterine magnet (IUM) or an intrauterine silicone-coated IUM, respectively, inserted into one of the uterine horns; in Group 5 an uncovered IUM was implanted subcutaneously. Six days later the rats were sacrificed; endometrial and subcutaneous tissues were harvested and examined microscopically. Results Copper IUDs caused classical cellular infiltration through the endometrium. IUMs, producing a static magnetic field, also caused leucocyte and monocyte infiltration of the endometrium and, in addition, a significant leucocyte accumulation over the endometrial surface. Conclusion This preliminary study reveals that an intrauterine magnet induces the accumulation of leucocytes in the uterine cavity in addition to the classic stromal infiltration caused by commercially available nonmagnetic IUDs. This activity could contribute to a greater efficacy of intrauterine contraception and should be investigated further.Öğe Follicular dendritic cell sarcoma associated with hyaline-vascular castleman's disease(Pakistan Medical Assoc, 2013) Cakir, Ebru; Aydin, N. Engin; Samdanci, Emine; Karadag, Nese; Sayin, Sadegul; Kizilay, AhmetFollicular dendritic cell sarcoma (FDCS) of the head and neck region, associated with Castleman's disease (CD), is an extremely rare entity. To the best of our knowledge, we report the first case demonstrating the transformation of the former into the latter as documented in the same lymph node disection material. A 45-year-old female presented to our hospital with right sided neck swelling. Radio logic imaging showed a well defined 3.5x3.5cm mass of soft tissue at the right side of the neck with multiple bilateral cervical lymph nodes. Excision of the right neck mass with lymph node disection was performed. Microscopic examination and immunohistochemical findings showed features of follicular dendritic cell sarcoma. The associated lymph nodes exhibited changes consistent with hyaline-vascular type CD, follicular dendritic cell hyperplasia and foci of overgrowth in which FDCS possibly evolved. This report confirms the evolving of FDCS in the setting of follicular dendritic cell hyperplasia occurring in Castleman's disease.Öğe Intertriginous plasmacytosis with plasmoacanthoma: report of a typical case and review of the literature(Blackwell Publishing, 2008) Senol, Mustafa; Ozcan, Atilla; Aydin, N. Engin; Hazneci, Ersoy; Turan, NergizClinical manifestations of benign (reactive) plasma cell proliferations of the skin and mucosa consist of a relatively rare and distinct group in dermatologic disorders. They have generally been named according to their localization. We report a typical case of mucocutaneous plasmacytosis located on intertriginous areas of the skin as well as mucosa with a perianal tumoral mass diagnosed as plasmoacanthoma. To our knowledge, this is the first detailed case report, at least in English literature.Öğe Intraductal Papillary Mucinous Neoplasia in Ectopic Pancreas Located in the Jejunum: Case Report(Ortadogu Ad Pres & Publ Co, 2011) Bassullu, Nuray; Turkmen, Ilknur; Yilmaz, Mehmet; Comunoglu, Cem; Aydin, N. EnginEctopic pancreas is a commonly seen congenital anomaly in gastrointestinal system, but jejunal pancreatic heterotopia is seen rarely. Although every pathological change that occurs in the pancreas can be seen in its heterotopic counterpart, neoplasia is an unusual complication. Intraductal papillary mucinous neoplasms (IPMNs) are tumors originate from ductal epithelial cells of the pancreas that constitute the main pancreatic duct or its major side branches and have a low incidence. Only two cases regarding the IPMN in heterotopic pancreas have been reported previously, but none of them were located in the jejunum. An IPMN in an ectopic pancreas tissue located in the jejunum in a 62-year-old male patient who presented with ileus is presented. It is important to recognize a tumor arising in heterotopic pancreas in order to prevent its misinterpretation as metastatic tumor or direct invasion of another tumor. To the best of our knowledge, this is the first reported IPMN case occurring in ectopic pancreas tissue located in the jejunum.Öğe Kalici Kateterlere Bagli Olmayan Polipoid Sistit: Sekiz Olgunun Sunumu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2002) Kiliç, Süleyman; Erguvan, Rezzan; Ipek, Deniz; Günes, Ali; Gökçe, Hasan; Aydin, N. Engin; Baydinç, CanKateterizasyon öyküsü olmayan polipoid sistitli hastalari degerlendirmek ve ilgili literatür isiginda tartismak amaçlandi. Materyal ve Metot: Turgut Özal Tip Merkezi’nin kayitlarinin retrospektif analizi ile kosulari uygun 8 hasta belirlendi. Bulgular: Iki kadin ve 6 erkek hasta degerlendirildi. Ortalama yas 48 idi (28-70). Dördünde mevcut olan üriner sitoloji bulgulari normaldi. Hiçbir hastada bakteriyel üreme tespit edilmedi. Bütün olgular hematüri, over apsesi, mesane karsinomu, erektil disfonksiyon, nörojenik mesane, benin prostat hiperplazisi ve açiklanamayan dizüri gibi farkli durumlarin degerlendirilmesinde radyolojik ve sistoskopik incelemelerle tesadüfen teshis edildi. Hastalar ilk tanidan sonra 6 aydan 2 yila kadar izlendi. Izlem süresince hiç rekürrens tespit edilmedi. Sonuçlar: Polipoid sistit benin bir lezyondur ve mesanenin transizyonel hücre karsinomunun ayirici tanisinda düsünülmelidir.Öğe Low-grade Epithelial-Myoepithelial Carcinoma of Bartholin Gland: Report of 2 Cases of a Distinctive Neoplasm Arising in the Vulvovaginal Region(Lippincott Williams & Wilkins, 2009) McCluggage, W. Glenn; Aydin, N. Engin; Wong, Newton A. C. S.; Cooper, KumarasenWe report 2 cases of a distinctive neoplasm arising from Bartholin gland and presenting as a vulval or vaginal mass. The tumors occurred in patients aged 44 and 51 years and were 2 and 3 cm in maximum dimension. In both cases, normal Bartholin gland tissue was identified adjacent to the lesion. The neoplasms were unencapsulated and largely well circumscribed but with a focally infiltrative edge. They were composed of tubular, trabecular, or insular arrangements with a double layer of inner cuboidal cells with round nuclei and outer cells with ovoid nuclei and clear cytoplasm, corresponding to epithelial and myoepithelial cells, respectively. Luminal eosinophilic colloid-like material was present. In both cases.. a minor proportion of the neoplasm consisted of cribriform arrangements, creating an appearance reminiscent of adenoid cystic carcinoma, although the overall morphology was not typical of that lesion. Mitotic figures were identified in both cases, the mitotic count being 1 and 5/10 high-power fields. Immunohistochemically, the inner cells were positive with epithelial markers. including broad-spectrum cytokeratins and epithelial membrane antigen, and the outer cell layer was positive with myoepithelial markers p63, calponin, and alpha-smooth muscle actin. Both neoplasms exhibited diffuse strong immunoreactivity of the epithelial cells with c-kit. Activating mutations in KIT exons 9, 11, 13, and 17 and in platelet-derived growth factor receptor alpha exons 12, 14, and 18 were searched for by polymerase chain reaction and direct sequencing but were not identified. We believe this represents a low-grade carcinoma arising from Bartholin gland composed of a dual population of epithelial and myoepithelial cells and closely resembling the salivary gland neoplasm termed epithelial-myoepithelial carcinoma. We propose the term low-grade epithelial-myoepithelial carcinoma of Bartholin gland.Öğe Submandibuiar Giand VVarthin Tümörü (Papiller Kistadenoma Lenfomatozum)(Turgut Özal Tıp Merkezi Dergisi, 1999) Atik, Esin; Erguvan, Rezzan; Aydin, N. EnginPapiller kistadenoma lenfomatozum, adenolenfoma veya daha sık kullanılan ismiyle VVarthin tümörü büyük çoğunlukla parotisde oluşan olağandışı bir tükürük bezi tümörüdür. En sık kabul edilen histogenez embriyonik hayatta parotis çevresi veya içindeki ienf düğümlerinde kalmış ' otan tükürük bezi dokusundan geliştiği yönündedir. Bu değişik tümörün bir örneğini 20 yaşında bir kadında submandibuiar giand yerleşimli olarak sunmaktayız.
