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Öğe Adenosquamous carcinoma of the prostate(1999) Turhan O.I.; Aydin N.E.; Sariyüce O.We present an unusual variant of prostatic adenocarcinoma with obvious squamous differentiation. The squamous component is represented by cells that contain vesicular or hyperchromatic nuclei and large acidophilic cytoplasm. We could demonstrate immunohistochemically the presence of prostate specific antigen (PSA) and glial fibrillary acidic protein (GFAP) in these tumour cells. Either in adenocarcinomatous or malignant squamous components, the prostatic epithelial cells showed the two markers, namely PSA, GFAP, which may reflect the multidirectional differentiation of these cells from a pluripotent origin.Öğe Cells in various benign and malignant conditions of the human prostate express different antigenic phenotypes(Akademiai Kiado Rt., 1998) Turhan O.I.; Aydin N.E.; Sariyüce O.; Özkan S.Prostatic epithelium basically consists of secretory-luminal, basal and endocrine-paracrine cells. Immunohistochemical procedures are frequently used for showing the cells reflecting different differentiations. In this study, 40 prostatic tissue specimens submitted to the Department of Pathology of Inonu University, Research Hospital, between 1991 and 1996 were examined. Half of the cases were diagnosed as cancer and the other half had various benign lesions. Of the cases 22.5% (n = 9) were needle biopsy material whereas the remainder, 47.5% (n = 19), were from prostatectomy and 30% (n = 12) were transurethral resection of the prostate (TURP) specimens. High molecular weight anti-cytokeratin antibodies (HMW anti-cytokeratin) stained basal cells both in all normal prostatic tissue and benign prostatic lesions, but in the majority of cancers (70%, n = 14) negative immunoreactivity was seen. Nevertheless, in some of the cancer cases (30%, n = 6) basal cell anti- cytokeratin staining was shown. Negative immunoreactivity with HMW anti- cytokeratin is important in distinguishing between malignant and benign lesions, whereas positive staining is not every time in favour of benign lesions. With the usage of prostate specific antigen (PSA) it was seen that all of the malignant and benign prostatic lesions stained positively. Basal cells in hyperplastic glands were not stained with this stain. Irregular, and in some areas, intense (PSA) immunoreactivity is present in precancerous and malignant lesions. Endocrine cells, which are represented with Chromogranin- A (Chr-A) immunoreactivity and reflecting neuroendocrine differentiation, are present in 75% (n = 15) of benign lesions and in 50% (n = 10) of cancer cases. It was thought that the lesser number of these cells in neoplastic lesions in comparison to the non-tumoral lesions is correlated with the disorder of mechanism that regulates the cell growth. Both in neoplastic and nontumoral tissues the prostatic epithelial cells showed the three markers, namely HMW anti-cytokeratin, PSA, and Chr-A, which may reflect the multidirectional differentiation of these cells from a pluripotent origin.Öğe Congenital malformations of the central nervous system(2001) Uzun A.; Aydin N.E.Congenital malformations of the central nervous system are common. They have assumed increasing importance in recent years because of sophisticated diagnostic methods and possibilities for genetic counselling and antenatal diagnosis of the abnormal fetus. Malformations may be primary or secondary; this review deals with primary malformations of the central nervous system. Chromosomal abnormalities can be inherited from a parent or new mutations can occur. Teratogens are external agents that alter a normal embryologic process in some way. When examining a case of congenital malformation, the morphologist should try to determine the specific features of the malformation and indicate, if possible, how that malformation may have been caused. Approximately 3 % of newborns have major malformations. About 60 % of congenital malformations are of unknown cause, and about 20 % are due to interactions between hereditary tendencies and nongenetic, usually undefined factors. There must be close cooperation between the morphologists and clinicans for precise understanding of the central nervous system malformations.Öğe Dural cavernous hemangioma originating from superior petrosal sinus(2002) Koçaki A.; Çayli S.R.; Önal S.Ç.; Kutlu R.; Aydin N.E.Cavernous angiomas of the dura are rare and have been described in the literature particularly in the middle cranial fossa. We present a case of cavernous hemangioma of the middle cranial fossa arising from the superior petrosal sinus. In our review of the literature, this is the 2nd report describing a cavernous hemangioma in such a location.Öğe Effect of nitric oxide on bacterial translocation in experimental intestinal obstruction(Turkish Surgical Society, 2001) Hasano?lu A.; Karadaş K.; Türköz Y.; Özerol I.H.; Tekereko?lu M.S.; Aydin N.E.; Ertaş E.Bacterial translocation is defined as the passage of endogenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs that suggested to be the cause of sepsis in patient with multiple organ failure. The aim of this study was to investigate the antibacterial effect of nitric oxide by using nitric oxide synthetase enzyme inhibitors such as L-NAME and aminoguanidin in the obstructive intestinal rat model. Fourty rats were divided into four groups. The first one was control group and had only laparatomy. Intestinal obstruction was performed to second group, intestinal obstruction + L-NAME (L-NG-nitro-L-arginine methyl ester) were applied to third group. Fourth group had intestinal obstruction and aminoguanidin was injected to them. According to the histopathological study of the intestine, group III demonstrated less ulceration than groups II and IV (p<0.05). Mucosal damage and bacterial translocation showed no correlation according to the results. The incidence of bacterial translocation was 46.6% in group II, 73.3% in group III and 90% in group IV. Eighty two percent of isolated bacteria was typical enteric Gram negative organisms. Bacterial translocation was not observed in control group. Plasma nitric oxide levels of groups were 14.0±3.3, 31.2±7.6, 12.2±2.5, and 10.5±1.8 ?mol/L, respectively. As a conclusion; nitric oxide can damage mucosal integrity that may increase bacterial translocation but the antibacterial effect of nitric oxide may be more effective and nitric oxide can decrease the translocation of bacteria from gut.Öğe [Histopathology of strobilocercosis found in the livers of white mouse.].(2010) Aydin N.E.; Miman O.; Gül M.; Daldal N.The adult form of Taenia taeniaeformis is found in the intestine of the cat and cheetah. The larva form is called Strobilocercus fasciolaris and is found in rodents such as mice and rats. Our objective was to draw attention to that rare zoonosis, since it has already been reported in the literature as strobilocercosis in humans. During an experimental animal study conducted at Inonu University, some unexpected cystic formations were found in the livers of nine 6-8-month-old healthy white mice, which affected the conducted study negatively. These cystic formations were examined histopathologically. Prepared sections were stained with haemotoxylin eosin, periodic acid-Schiff and Masson trichrome stains, and examined by light microscopy. Strobilocercus fasciolaris larvae that curled towards cyst cavity and their hooks were seen. Plasma cells, macrophage, focus of eosinophilic infiltration and fibroblastic connective tissue were simultaneous found. In this paper, histopathological changes in intermediate hosts caused by Strobilocercus fasciolaris and other cestod larvae have been discussed.Öğe The influence of atorvastatin on tendon healing: An experimental study on rabbits(2010) Esenkaya I.; Sakarya B.; Unay K.; Elmali N.; Aydin N.E.Hyperlipidemia is a major risk factor for coronary heart disease. The most commonly used antihyperlipidemic drugs are 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins), of which atorvastatin is one of the most widely used. Little is known about the relationship between tendinopathy and HMG CoA reductase inhibitors (statins) or the effects of atorvastatin use on tendon healing following surgical repair of tendon rupture. We hypothesized that atorvastatin negatively affects this healing process. The Achilles tendons of 16 New Zealand rabbits were ruptured surgically and repaired with sutures. Eight of the rabbits were given oral atorvastatin. The other 8 served as a surgical control group. Six weeks postoperatively, all the rabbits were sacrificed, and the repaired tendons were removed. After standard histological preparation, fibroblastic activity, revascularization, collagenization, collagen construction, and inflammatory-cell infiltration were evaluated. On comparing the atorvastatin and surgical control groups, we observed no difference in fibroblastic activity. Although it did not reach statistical significance in our study, a difference was noted in revascularization, collagenization, and inflammatory cell infiltration; and a statistical difference was observed in collagen construction. Doubt remains about the adverse effect of atorvastatin use during tendon healing. Further investigations in animal and human models are needed on the effects of tendon healing when atorvastatin is administered for a longer time frame prior to the injury.Öğe Internal mammary artery atherosclerosis in segments removed during coronary artery bypass grafting surgery and C. Pneumoniae infection(2004) Ege E.; Paç M.; Durmaz R.; Bulut Y.; Hazar A.; Emmiler M.; Aydin N.E.Objective: Recent studies suggest the association of atherosclerotic cardiovascular disease with Chlamydia pneumoniae infection. We investigated C. pneumoniae DNA in internal mammarian artery (IMA) (used as a coronary bypass conduit) and its relationship with atherosclerosis. Methods: Sixty-six consecutive patients who underwent coronary artery bypass grafting (CABG) during an eight-month period were included in this study. From all patients, we attempted to obtain surplus segments of harvested IMA grafts. The vessels were examined histopathologically, and presence of C. pneumoniae DNA in IMA grafts was assessed by polymerase chain reaction (PCR). Results: C. pneumoniae DNA was found in 7 (10.6%) of 66 IMA specimens. The light microscopic examinations of IMA segments from the C. pneumonia positive group showed atherosclerotic intimal changes in four of the seven patients. These atherosclerotic changes were type II in three patients and type III in one patient according to the AHA classification. The rest of the IMA segments from 62 patients did not show any discernible atherosclerotic lesion. Conclusion: The IMA graft examination by PCR and histopathology may be helpful in the determination of future graft patency for IMA bypass surgery.Öğe Rare sclerosing stromal tumor of the ovary: A case report(Logos Medical Publishing, 2009) U?uralp S.; Güngör A.; Si?irci A.; Şamdanci E.; Aydin N.E.Sclerosing stromal tumor (SST) is a rare benign ovarian neoplasm of stromal origin. This disease most frequently occurs in young women under 30 years old. 15-year-old girl presented with a right ovarian complex cystic mass on abdominal ultrasonography. The CA-125 value was increased mildly. Other tumor markers were normal. Pelvic magnetic resonance imaging showed a large right ovary including heterogenic area, thick septa and contrast-enhanced cystic area. Intraoperatively, a hard, lobular, whitish-yellow fibrotic ovarian tumor including cystic area was identified. Oophorectomy was performed. Histologically, SST was reported. It must be remembered that when a white-yellow and hard ovarian tissue is identified intraoperativel, the rare SST of the ovary maybe present.
