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Öğe Assessment of change in neutrophil-lymphocyte ratio, platelet-lymphocyteratio in patients with acute and chronic urticaria(2018) Gür, Ali; Turgut, Kasım; Güven, Taner; Aytemur, Zeynep Ayfer; Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Yumrutepe, SevgiAbstract: Aim: Urticaria is a skin disease characterized by erythematous, oedematous, itchy,and spontaneously disappearing urticaria lesions. One of the most common skin diseases, it is the most common reason underlying the presentations to emergency departments. Our objective is to investigate the role of systemic inflammation in urticaria pathogenesis by measuring the indicators of Neutrophil-Lymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) in routine hemograms in patients with acute and chronic urticaria. Material and Methods: Of patients visiting the Dermatology Policlinic of İnönü University Medical School Hospital between July 2017 and February 2018, 69 patients diagnosed with acute urticaria and 188 patients diagnosed with chronic urticaria as well as 90 healthy people taken as controls with an age range of 18to 70 were included in our study. Blood values of patients were studied retrospectively. (For the study, a Research Ethics Approval was obtained from Malatya Research Ethics Board.) Results: No significant difference was detected among the study groups in terms of demographic properties. Whereas a significant difference was noted among the three groups with regard to NLR values, no statistically significant difference was detected among the groups with respect to PLR values. No statistically significant difference was observed between the group of patients with urticaria and the control group in terms of erythrocyte distribution(p: 0.01). On the other hand, when the patient group with chronic urticaria was divided into two subgroups as patients with a complaint duration of 90 days and less, and those with a complaint duration of more than 90 days and evaluated, no statistically significant difference was detected between these groups in terms of RDW, lymphocytes, neutrophils, platelets, NLR and PLR values Conclusion: In our study, we have determined that systemic inflammation has increased in the group of patients with urticaria as compared to the control group. What’s more interesting in this study is our conclusion that the pathways involved in continued inflammation do not change by time in chronic urticaria.Öğe Can the use of smokeless tobacco products be Accepted as a harm reduction method in tobacco Addiction?(2014) Öztuna, Funda; Aytemur, Zeynep Ayfer; Elbek, Osman; Kılınç, Oğuz; Küçük Uyanusta, Çağla; Akçay, Müşerref Şule; Dağlı, ElifAbstract: The goal of smoking cessation treatment is to keep the patient completely away from tobacco and tobacco products. The aim of harm reduction strategies in tobacco control is to reduce the risks associated with tobacco use. In order to turn it into an opportunity, tobacco companies have developed smokeless tobacco products. Some epidemiological studies have reported that smokeless tobacco products are safer than tobacco smoke. However, this method is not completely harmless. In this review, we will discuss all aspects of tobacco harm reduction methods.Öğe Diffusion-weighted magnetic resonance imaging of thorax in diagnosis of pulmonary embolism(2018) Gür, Ali; Turgut, Kasım; Güven, Taner; Aytemur, Zeynep Ayfer; Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Yumrutepe, SevgiAbstract: Pulmonary embolism (PE) has a high mortality rate and a considerable incidence in emergency care. Thorax computed tomography (CT) angiography is the primary diagnosis method for PE, but has many contraindications. In the present study, we aimed to determine the usability of Diffusion-weighted magnetic resonance imaging (DWMRI) in diagnosis of pulmonary embolism. Patients, diagnosed as pulmonary embolism previously by thorax CT angiography, were taken DWMRI. Demographic parameters, complaints, laboratory values and imaging findings were recorded on standart forms. Twenty nine patients, who were diagnosed as pulmonary emboli, were evaluated. Many of them were female(69%) and the mean of age was 61 years. Dyspnea and chest pain were the main complaints. Atelectasis(69,1%) and pulmonary infarct(30,9%) were determined lesions on CT and DWMRI. Region of interest (ROI) were determined by using MRI (T2) images. Three different ROI values were placed on areas and apparent diffusion coefficient (ADC) values were calculated for peripheric lung lesions. Significant difference was determine between mean ADC values of atelectasis and pulmonary infarct lesions (p<0.05). DWMRI can differentiate peripheric lesions in PE patients, but it is not adequate for diagnosis of PE.Öğe Orta ve ağır astımlı olgularda alerjik bronkopulmoner aspergilloz(2008) Aydoğan, Öznur; Erdinç, Münevver; Aytemur, Zeynep Ayfer; Sin, Aytül; Savaş, RecepÖz: Giriş: Allerjik bronkopulmoner aspergilloz (ABPA), ağır astımlı olgularda görülmektedir ve aspergillus antijenlerine aşırı duyarlılık nedeni ile oluşmaktadır. ABPA sıklığına dair bilgiler, farklı tanısal kriterlerin kullanıldığı az sayıda çalışma nedeniyle tahmine dayalıdır. Gereç ve Yöntem: Bu çalışmada; orta ve ağır persistan astımlı olgularda ABPA sıklığı araştırılmıştır. ABPA-Santral bronşektazi (ABPA-SB) tanısı; astım, santral bronşektazi, Aspergillus fumigatus deri testi pozitifliği veya serumda aspergillus sIgE pozitifliği; ABPA-Seropozitif (ABPA-S) tanısı; astım, yüksek total IgE düzeyi, Aspergillus fumigatus deri testi pozitifliği ve serumda aspergillus sIgE saptanması ile konmuştur. Bulgular: Altmış dört olgunun %71.9'u orta, %28.2'si ağır persistan astımdır. Aspergillus sIgE, 2 (%3.1) olguda pozitiftir. Deri testlerinde A. fumigatus pozitifliği toplam 4 olguda (%7.8) gösterilmiştir. YRBT ile 7 (%14.6) olguda santral bronşektazi ve 1 (%2) olguda santral yerleşimli mukus tıkacı saptanmıştır. Çalışmamızda 2 (%3.1) olgu ABPA-SB tanısı almıştır. İki (%3.1) olgu ise aspergillus duyarlı astım olarak değerlendirilmiştir. Sonuç: ABPA'lı olgular, ağır persistan astımlı olgulardır. Bu nedenle kontrolü güç ağır astım olgularında ABPA düşünülmelidir.Öğe The Role of First-Pass Perfusion Computed Tomography in the Differentiation of Centrally Located Lung Cancer and Distal Atelectasis(2016) Erbay, Mehmet Fatih; Baysal, Tamer; Aytemur, Zeynep AyferAbstract: Our aim in this study was to differentiate postobstructive consolidation from lung cancer by means of first-pass perfusion CT in centrally located malignancies. We studied 20 patients (18 males and 2 females) diagnosed as lung cancer with untreated central masses and distal postobstructive atelectasis. In order to localize the slice position showing the appropriate mass-consolidation area to be included in contrast-enhanced dynamic imaging, we first performed scout and baseline acquisition without contrast media, followed by dynamic acquisition after intravenous contrast media injection. Three different ROIs were placed on the central mass while avoiding the peripheral regions as much as possible and on the peripheral locations of distal consolidation using dynamic contrast-enhanced images. The BV, BF, TTP and MTT perfusion parameters were automatically calculated in the ROI locations. We were able to differentiate the central masses from distal consolidations by means of statistical differences in the first-pass BV and BF parameters between the mass and distal consolidation areas. The mean values of parameters that were calculated in the mass and consolidation areas were BV: 7.69±4.28 ml/100g, BF: 48.87±25.54 ml/100g/min, TTP: 27.94±7.32 sec., MTT: 9.56±3.47 sec. and BV: 11.83±5.34 ml/100g, BF: 78.75±39.41 ml/100g/min, TTP: 29.72±6.05 sec., MTT: 11.44±4.93 sec., respectively. We concluded that first-pass perfusion CT may be used as a functional imaging method to differentiate central lung cancer from distal consolidation and could be useful in reducing the target cancer volume in patients who are candidates for radiation therapy.
