Orta ve ağır astımlı olgularda alerjik bronkopulmoner aspergilloz
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Tarih
2008
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info:eu-repo/semantics/openAccess
Özet
Öz: Giriş: Allerjik bronkopulmoner aspergilloz (ABPA), ağır astımlı olgularda görülmektedir ve aspergillus antijenlerine aşırı duyarlılık nedeni ile oluşmaktadır. ABPA sıklığına dair bilgiler, farklı tanısal kriterlerin kullanıldığı az sayıda çalışma nedeniyle tahmine dayalıdır. Gereç ve Yöntem: Bu çalışmada; orta ve ağır persistan astımlı olgularda ABPA sıklığı araştırılmıştır. ABPA-Santral bronşektazi (ABPA-SB) tanısı; astım, santral bronşektazi, Aspergillus fumigatus deri testi pozitifliği veya serumda aspergillus sIgE pozitifliği; ABPA-Seropozitif (ABPA-S) tanısı; astım, yüksek total IgE düzeyi, Aspergillus fumigatus deri testi pozitifliği ve serumda aspergillus sIgE saptanması ile konmuştur. Bulgular: Altmış dört olgunun %71.9'u orta, %28.2'si ağır persistan astımdır. Aspergillus sIgE, 2 (%3.1) olguda pozitiftir. Deri testlerinde A. fumigatus pozitifliği toplam 4 olguda (%7.8) gösterilmiştir. YRBT ile 7 (%14.6) olguda santral bronşektazi ve 1 (%2) olguda santral yerleşimli mukus tıkacı saptanmıştır. Çalışmamızda 2 (%3.1) olgu ABPA-SB tanısı almıştır. İki (%3.1) olgu ise aspergillus duyarlı astım olarak değerlendirilmiştir. Sonuç: ABPA'lı olgular, ağır persistan astımlı olgulardır. Bu nedenle kontrolü güç ağır astım olgularında ABPA düşünülmelidir.
Abstract: Introduction: Allergic bronchopulmonary aspergillosis (ABPA), which is predominantly a disease of severe asthmatic patients, is caused by hypersensitivity to aspergillus antigens. The prevalence of ABPA is speculative, as the few studies that were performed adopted widely different diagnostic criteria. Material and Method: In this study, we aimed to evaluate the prevalence of ABPA in patients with moderate and severe asthma. ABPA-Central bronchiectasis (ABPA-SB) was diagnosed if a patient had asthma, central bronchiectasis, positive Aspergillus fumigatus skin test or positive serum aspergillus sIgE. ABPA-Seropositive (ABPA-S) was diagnosed if a patient had asthma, elevated total IgE level, positive Aspergillus fumigatus skin test and positive serum aspergillus sIgE. Results: Of the sixty four patients, 71.9% had moderate asthma and 28.2% severe asthma. Positive Aspergillus sIgE was present in 2 patients (3.1%). Sensitivity to A. fumigatus with skin test was shown in a total of 4 (7.8%) patients. Central bronchiectasis was seen on HRCT in seven of the patients (14.6%) and central mucus impaction was seen in one patient (2%). In this study, ABPA was diagnosed in 2 (3.1%) patients. Two (3.1%) patients were evaluated as aspergillus-sensitive asthma. Conclusion: Patients with ABPA had severe asthma. Therefore, ABPA should be considered in patients with poorly controlled severe asthma
Abstract: Introduction: Allergic bronchopulmonary aspergillosis (ABPA), which is predominantly a disease of severe asthmatic patients, is caused by hypersensitivity to aspergillus antigens. The prevalence of ABPA is speculative, as the few studies that were performed adopted widely different diagnostic criteria. Material and Method: In this study, we aimed to evaluate the prevalence of ABPA in patients with moderate and severe asthma. ABPA-Central bronchiectasis (ABPA-SB) was diagnosed if a patient had asthma, central bronchiectasis, positive Aspergillus fumigatus skin test or positive serum aspergillus sIgE. ABPA-Seropositive (ABPA-S) was diagnosed if a patient had asthma, elevated total IgE level, positive Aspergillus fumigatus skin test and positive serum aspergillus sIgE. Results: Of the sixty four patients, 71.9% had moderate asthma and 28.2% severe asthma. Positive Aspergillus sIgE was present in 2 patients (3.1%). Sensitivity to A. fumigatus with skin test was shown in a total of 4 (7.8%) patients. Central bronchiectasis was seen on HRCT in seven of the patients (14.6%) and central mucus impaction was seen in one patient (2%). In this study, ABPA was diagnosed in 2 (3.1%) patients. Two (3.1%) patients were evaluated as aspergillus-sensitive asthma. Conclusion: Patients with ABPA had severe asthma. Therefore, ABPA should be considered in patients with poorly controlled severe asthma
Açıklama
Anahtar Kelimeler
Kaynak
Türk Toraks Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
4
Künye
AYDOĞAN Ö,ERDİNÇ M,AYTEMUR Z. A,SİN A,SAVAŞ R (2008). Orta ve ağır astımlı olgularda alerjik bronkopulmoner aspergilloz. Türk Toraks Dergisi, 9(4), 151 - 156.
