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Öğe Effects of acrylamide and crocin on rat lung tissue(2022) Erdemli, Zeynep; Erdemli, Mehmet Erman; Bağ, Harika Gözükara; Altınöz, EyüpAim: We aimed to determine the effects of acrylamide (AA) and crocin (Cr) on rat lung tissues. Materials and Methods: Forty Wistar albino rats were divided into control, AA, Cr, and AA + Cr groups. Rats were administered 25 mg/kg AA and 50 mg/kg Cr for 21 days. After 21 days, malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT) and protein levels were measured in rat lung tissues. Results: The analysis of the rat lung tissues revealed that oxidant parameter markers (MDA, TOS, OSI) increased and antioxidant parameter markers (GSH, TAS, SOD, CAT) decreased in the AA group when compared to all other groups (p < 0.05). A significant increase was determined in antioxidant capacity (GSH, TAS, SOD, CAT) in the Cr-treatment group when compared to all other groups (p < 0.05). We found a significant improvement in oxidant-antioxidant parameters in the AA + Cr group when compared to the AA group (p < 0.05). Conclusion: This study was the first of its kind in the literature and revealed that AA administration led to damages in lung tissue. It could be suggested that this was due to an increase in oxidant levels and oxidative stress. Cr exerted a powerful antioxidant effect in lung tissues. Against AA toxicity, we recommend the consumption of Cr to improve antioxidant capacity.Öğe Effects of renal replacement therapy on fıbromyalgıa syndrome ın patıents wıthchronıc kıdney dısease(CARBONE EDITORE, VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY, 2018) Şahin, İdris; Bağ, Harika GözükaraIntroduction: Although musculoskeletal disorders are among the major complications of chronic kidney disease (CKD), there are scarce data to investigate fibromyalgia syndrome (FMS) in these patients. We aimed to investigate the prevalence of FMS in the patients with CKD. Material and methods: A total of 289 (119 predialysis (PD), 85 hemodialysis (HD), 85 continuous ambulatory peritoneal dialysis (CAPD)) patients were included. Diagnosis of FMS was based on American College of Rheumatology (ACR) 1990 FMS criteria. Results: Mean age was 52 +/- 16 years (range 18-89 years). One-hundred-sixty-four (56.7%) of them were male. A total of 46 patients (10 male/36 female) (15.9%) were diagnosed FMS. The prevalence of FMS was 28.8% in females and 6.1% in males. Compared to males, females had a significantly higher rate of FMS (p<0.001). The prevalence of FMS was 19.3% in PD group, 17.6% in the CAPD group, and 9.4% in the HD group. Although the frequency of FMS was lower in HD group compared to both the PD and the CAPD groups, the differences were not statistically significant (for HD vs PD, p=0.052; for HD vs CAPD, p=0.113). In PD group, hemoglobin (Hb) levels were significantly higher in patients with FMS than without FMS. Parathormone (PTH) levels were significantly lower in CAPD patients with FMS than without FMS. Although the prevalence of FMS was increased in PD and CAPD patients, this increase did not reach statistical significance. FMS was markedly more prevalent in female patients. While the Hb level was lower in the PD patients with FMS, PTH level was lower in the CAPD patients diagnosed with FMS. Conclusions: Our study demonstrated that the rate of FMS was higher in PD and CAPD patients compared to HD patients, although our results did not reach statistical significance. Among the entire demographic and laboratory parameters, female gender was found to be significant risk factor for development of FMS. Future multicenter studies which have large sample size are clearly needed to determine other factors related to development of FMS in patients with CKD.Öğe Evaluation of the frequency, follow-up, and treatment of patients with multisystem inflammatory syndrome related to COVID-19(2022) Öncül, Mehmet; Karakurt, Cemşit; Elkıran, Özlem; Tekin, Mehmet; Bağ, Harika GözükaraAim: Aim of this study is evaluate the clinical features, laboratory values, treatment and follow-up of in children with COVID-19-associated multisystem inflammatory syndrome (MIS-C) disease. Materials and Methods: In this study, patients aged between 2 months and 17 years, who applied to the Inonu University Faculty of Medicine, Department of Pediatrics between March 2020, and February 2021 due to MIS-C related to COVID-19 disease, were reviewed retrospectively. Demographic data, clinical features, laboratory values, treatment and follow-up data of the patients were evaluated. Results: Forty-nine patients diagnosed with MIS-C between March 2020 and February 2021 were included in the study. Thirty-one (72.7%) patients were male and 18 (27.3%) were female. The most common indications for admission were fever (100%), abdominal pain (51.6%), vomiting (42.9%), cough (38.8%), diarrhea (28.8%), shortness of breath, rash, conjunctivitis, and convulsion. Levels of CRP (93.9%), D-dimer (85.7%), fibrinogen (73.4%), interleukin 6 (IL6) (73.4%), procalcitonin (71.4%), NT-proBNP (63.2%) remained at high levels in respective number of patients. The (32.6%) patients were followed up in the intensive care unit. These patients had cardiogenic shock (26.5%), severe pneumonia (18.3%), and acute gastroenteritis (14.3%). It was determined that the mean age of the patients followed up for cardiogenic shock was 12.5 years and relatively higher (p<0.05). One patient died during follow-up. Conclusion: Although the manifestations of MIS- C due to COVID -19 are seen relatively rarely in children, it constitutes a serious problem and they mostly require hospitalization in intensive care unit, simultaneously involves many organ systems, and leads a serious course with higher risk of mortality. Another problem in these patients is higher rates of cardiac involvement. For this reason, it is important to take necessary precautions to protect children against COVID 19 and its associated MIS-C, and to include them in vaccination programs.Öğe İnönü Üniversitesi Tıp Fakültesi 1. ve 6. Sınıf Öğrencilerinin Gözünden Hekime Şiddet Nedenleri(Acıbadem Sağlık Bilimleri Dergisi, 2018) Tetik, Burcu Kayhan; Bağ, Harika Gözükara; Paksoy, Nur; Tural, Cansu; Gedik, Işılay; Sertkaya, SerapÖZET Amaç: Bu çalışmanın amacı 1. ve 6. Sınıf tıp fakültesi öğrencilerinin gözünden hekime şiddet nedenlerini araştırmak, bu konudaki bilgi düzeylerini belirleyebilmek ve sağlıkta şiddet ile ilgili farkındalıklarını artırabilmektir. Gereç - Yöntem: İnönü Üniversitesi Tıp Fakültesi 1. ve 6. Sınıf öğrencilerinden çalışmaya katılmayı kabul eden 246 öğrenci alınmıştır. Hekime neden şiddet uygulanabileceği ile ilgili hazırlanan sorulardan oluşan anket uygulanmıştır. Veriler SPSS 22 prog ile değerlendirilmiştir. Bulgular: Çalışmaya toplam 246 öğrenci katılmıştır. Öğrencilere en yaygın şiddet sebeplerinin ne olduğu sorulduğunda, dönem 1 öğrencilerinin %26.8’i, dönem 6 öğrencilerinin %61.3’ü “Muayene olmak için hastanın çok bekletilmesi” cevabını vermiş ve bu fark istatistiksel olarak anlamlı kabul edilmiştir (p<0.001). Aynı soruya dönem 1 öğrencilerinin %28.8’i dönem 6 öğrencilerinin %8.6‘sı “Doktorun hastayı muayene etmeden ilaç yazması” cevabını vermiş ve bu fark istatistiksel olarak anlamlı kabul edilmiştir (p<0.001). Sonuç: Toplumda yaygınlaşma eğilimi gösteren şiddet, sağlık sektörünü de ciddi biçimde etkilemektedir. Bu nedenle tıp fakültelerinde mezuniyet öncesi dönemde; hasta ile etkili iletişim kurabilme ve şiddete maruziyet durumunda sahip oldukları hukuki hakları ile ilgili derslerin müfredata eklenmesinin daha uygun olduğunu ayrıca yasal mevzuatın eksikliği de dikkate alınarak yeni hukuki düzenlemeler yapılabilmesi için ilgili mercilerle görüşmelerin yapılmasının gerekliliğini vurgulamak istedik. Anahtar sözcükler: Şiddet, tıp öğrencisi, etkili faktörlerÖğe Investigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats(TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA, 2018) Gül, Mehmet; Yiğitcan, B.; Bağ, Harika Gözükara; Aksungur, ZWe investigated repair of acrylamide (AA) induced damage in intestines by administration of crocin. We used 40 male Wistar rats in four groups of 10 animals: control, AA, crocin, and AA + crocin groups. We investigated biochemical and histological changes to small and large intestine. AA ingestion decreased glutathione (GSH) levels and total antioxidant status (TAS) in the intestine compared to the control group, while superoxide dismutase (SOD) and catalase (CAT) activities, and total oxidant status (TOS) and malondialdehyde (MDA) levels were increased. Villi were shortened and villus degeneration was observed in ileum of the AA group. Degeneration of surface epithelium and Liberkuhn crypts were observed in colon sections. GSH and TAS levels increased after administration of AA together with crocin, while SOD and CAT levels and TOS and MDA levels decreased; significant recovery of histological damage also was observed. We found that crocin exhibits protective effects on AA induced small and large intestine damage by inhibiting oxidative stress.
