Investigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We investigated repair of acrylamide (AA) induced damage in intestines by administration of crocin. We used 40 male Wistar rats in four groups of 10 animals: control, AA, crocin, and AA + crocin groups. We investigated biochemical and histological changes to small and large intestine. AA ingestion decreased glutathione (GSH) levels and total antioxidant status (TAS) in the intestine compared to the control group, while superoxide dismutase (SOD) and catalase (CAT) activities, and total oxidant status (TOS) and malondialdehyde (MDA) levels were increased. Villi were shortened and villus degeneration was observed in ileum of the AA group. Degeneration of surface epithelium and Liberkuhn crypts were observed in colon sections. GSH and TAS levels increased after administration of AA together with crocin, while SOD and CAT levels and TOS and MDA levels decreased; significant recovery of histological damage also was observed. We found that crocin exhibits protective effects on AA induced small and large intestine damage by inhibiting oxidative stress.
Açıklama
Anahtar Kelimeler
Oxıdatıve Stress, Actıve Constıtuent, Maıllard Reactıon, Saffron Extract, Satıvus L., Mıce, Toxıcıty, Glycıdamıde, Metabolısm, Expressıon
Kaynak
Bıotechnıc & hıstochemıstry
WoS Q Değeri
Scopus Q Değeri
Cilt
93
Sayı
4
Künye
Gül, M. Yiğitcan, B. Bağ, HG. Aksungur, Z. (2018). Investigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats. Cilt:93 Sayı:4, 267-376 ss.
