Investigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats

Basit Öğe Kaydı
dc.contributor.authorGül, Mehmet
dc.contributor.authorYiğitcan, B.
dc.contributor.authorBağ, Harika Gözükara
dc.contributor.authorAksungur, Z
dc.date.accessioned2019-07-18T10:23:55Z
dc.date.available2019-07-18T10:23:55Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated repair of acrylamide (AA) induced damage in intestines by administration of crocin. We used 40 male Wistar rats in four groups of 10 animals: control, AA, crocin, and AA + crocin groups. We investigated biochemical and histological changes to small and large intestine. AA ingestion decreased glutathione (GSH) levels and total antioxidant status (TAS) in the intestine compared to the control group, while superoxide dismutase (SOD) and catalase (CAT) activities, and total oxidant status (TOS) and malondialdehyde (MDA) levels were increased. Villi were shortened and villus degeneration was observed in ileum of the AA group. Degeneration of surface epithelium and Liberkuhn crypts were observed in colon sections. GSH and TAS levels increased after administration of AA together with crocin, while SOD and CAT levels and TOS and MDA levels decreased; significant recovery of histological damage also was observed. We found that crocin exhibits protective effects on AA induced small and large intestine damage by inhibiting oxidative stress.en_US
dc.identifier.citationGül, M. Yiğitcan, B. Bağ, HG. Aksungur, Z. (2018). Investigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats. Cilt:93 Sayı:4, 267-376 ss.en_US
dc.identifier.doi10.1080/10520295.2018.1432888en_US
dc.identifier.endpage276en_US
dc.identifier.issue4en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://hdl.handle.net/11616/12739
dc.identifier.volume93en_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USAen_US
dc.relation.ispartofBıotechnıc & hıstochemıstryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxıdatıve Stressen_US
dc.subjectActıve Constıtuenten_US
dc.subjectMaıllard Reactıonen_US
dc.subjectSaffron Extracten_US
dc.subjectSatıvus L.en_US
dc.subjectMıceen_US
dc.subjectToxıcıtyen_US
dc.subjectGlycıdamıdeen_US
dc.subjectMetabolısmen_US
dc.subjectExpressıonen_US
dc.titleInvestigation of the protective effects of crocin on acrylamide induced small and large intestine damage in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
1.6 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı Koleksiyonu