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Öğe Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study(Mosby-Elsevier, 2011) Ozturk, Firat; Babacan, Hasan; Inan, Sevinc; Gumus, CesurIntroduction: The aim of this experimental study was to evaluate the effects of systemically applied zoledronic acid on bone regeneration in response to expansion of the sagittal suture and relapse in rats. Methods: Thirty-six male Wistar rats were divided into 3 groups. In the first and second groups, saline solution was given subcutaneously after expansion, and the retention periods lasted 14 and 7 days, respectively. In the third group, 0.1 mg of zoledronic acid was diluted with saline solution and given subcutaneously after expansion; the retention period lasted for 7 days. Expansion and relapse amounts were measured by using computed tomography. After the retention period, 6 rats from each group were killed for histologic and immunohistochemical assessments. The other 6 rats from each group were used for observation of the relapse. Results: The histologic evaluation showed that, in groups 1 and 2, the numbers of osteoblasts were less than observed in group 3. When scores of staining intensity were compared, immunoreactivities were statistically significantly increased in group 3 compared with groups 2 and 1. Statistically significant differences were found when the relapse percentages were compared between the groups (P < 0.05). The smallest relapse occurred in group 3. Conclusions: Zoledronic acid has positive effects on bone formation in the sagittal suture in response to expansion and decreases the relapse ratio after expansion in rats. (Am J Orthod Dentofacial Orthop 2011; 140: e31-e41)Öğe Effects of direct and indirect bonding techniques on bond strength and microleakage after thermocycling(Korean Assoc Orthodontists, 2009) Ozturk, Firat; Babacan, Hasan; Nalcaci, Ruhi; Kustarci, AlperObjective: The purpose of this study was to compare the shear bond strength (SBS) of brackets and microleakage of a tooth-adhesive-bracket complex bonded with a direct and an indirect bonding technique after thermocycling. Methods: Fifty non-carious human premolars were divided into two equal groups. In the direct bonding group a light-cured adhesive and a primer (Transbond XT) was used. In the indirect-bonding group, a light-cured adhesive (Transbond XT) and chemical-cured primer (Sondhi Rapid Set) were used. After polymerization, the teeth were kept in distilled water for 24 hours and thereafter subjected to thermal cycling (500 cycles). For the microleakage evaluation, 10 teeth from each group were further sealed with nail varnish, stained with 0.5% basic fuchsin for 24 hours, and examined under a stereomicroscope. Fifteen teeth from each group were used for SBS testing with the universal testing machine and adhesive remnant index (ARI) evaluation. Data were analyzed using the Mann-Whitney U test, Chi-square test, and Fisher's exact test. Results: There were no statistical differences on SBS and microleakage between the two bonding techniques. The indirect bonding group had a significantly lower ARI score. Bracket failures were obtained between enamel-resin interfaces. Conclusions: The type of bonding technique did not significantly affect the amount of microleakage and SBS. (Korean J Orthod 2009;39(6):393-401)Öğe Effects of zoledronic acid on sutural bone formation: a computed tomography study(Oxford Univ Press, 2012) Ozturk, Firat; Babacan, Hasan; Gumus, CesurThe aim of this study was to investigate the effects of systemically applied zoledronic acid (ZA) on osteoblastic bone formation and relapse in the rat sagittal suture after expansion. Eighteen 12-week-old male Wistar rats were divided into three groups. In groups 1 and 2, a saline solution was given subcutaneously after expansion and the retention period lasted for 14 and 7 days, respectively. In group 3, 0.1 mg of ZA was diluted with saline and given subcutaneously after expansion: the retention period lasted for 7 days. Computed tomography (CT) measurements were obtained at the start of the study (T1), after expansion (T2), after the retention period (T3), and after the follow-up period (T4). The amount of expansion and relapse and the density of the newly formed bone in the expansion area were measured. The mean bone density values in hounsfield unit (HU) of the newly formed bone were recorded using MX View Workstation. Data were analysed using the Kruskal-Wallis, Friedman, Wilcoxon, and Mann-Whitney U-tests. The results showed that there were significant differences between the groups in the density of newly formed bone after the retention period (P < 0.05). Statistically significant differences were observed when the relapse percentages were compared between the groups (P < 0.05). ZA stimulated bone formation and decreased the relapse ratio after expansion in the rat sagittal suture.Öğe Identical unerupted maxillary incisors in monozygotic twins(Mosby-Elsevier, 2010) Babacan, Hasan; Ozturk, Firat; Polat, Hidayet BurakMesiodens is the most common type of supernumerary tooth found in the premaxilla. It might be discovered by the orthodontist by chance on a radiograph or as the cause of an unerupted maxillary central incisor. The genetic transmission of supernumerary and impacted teeth is poorly understood. The occurrence of identical unerupted maxillary central incisors and mesiodentes in monozygotic twins suggests that genetic factors might influence the etiology of this problem. In this case report, we discuss the treatment of unerupted maxillary permanent incisors caused by mesiodentes in monozygotic twins. (Am J Orthod Dentofacial Orthop 2010;138:498-509)Öğe Simplified Indirect Bonding Technique for Lingual Retainer Fabrication(Aves Press Ltd, 2012) Ozturk, Firat; Babacan, Hasan; Topcuoglu, TolgaAim: The aim of this study was to describe a simplified technique for fabricating an indirectly bonded lingual retainer using a light cure composite resin and clear tape. Subjects and Methods: Lingual retainers, made of dead soft wire, were tended to the lingual contour of the lower incisors on the stone models of patients and placed to the mouth. Fabricating lingual retainers with this method were used in 6 patients who were followed for 6 months. Results: During this period, failures occurred in 2 teeth. One failure was on a canine; the other one is on an incisor. Conclusion: Due to the isolation done with a clear tape in this method, there is no need for an extra procedure for the removal of the remnants of the separating medium from the resin surface. These extra procedures applied can cause the degradation of the resin surface which may lead to bonding failures (Turkish J Orthocl 2012;25:47-52)