Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mosby-Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: The aim of this experimental study was to evaluate the effects of systemically applied zoledronic acid on bone regeneration in response to expansion of the sagittal suture and relapse in rats. Methods: Thirty-six male Wistar rats were divided into 3 groups. In the first and second groups, saline solution was given subcutaneously after expansion, and the retention periods lasted 14 and 7 days, respectively. In the third group, 0.1 mg of zoledronic acid was diluted with saline solution and given subcutaneously after expansion; the retention period lasted for 7 days. Expansion and relapse amounts were measured by using computed tomography. After the retention period, 6 rats from each group were killed for histologic and immunohistochemical assessments. The other 6 rats from each group were used for observation of the relapse. Results: The histologic evaluation showed that, in groups 1 and 2, the numbers of osteoblasts were less than observed in group 3. When scores of staining intensity were compared, immunoreactivities were statistically significantly increased in group 3 compared with groups 2 and 1. Statistically significant differences were found when the relapse percentages were compared between the groups (P < 0.05). The smallest relapse occurred in group 3. Conclusions: Zoledronic acid has positive effects on bone formation in the sagittal suture in response to expansion and decreases the relapse ratio after expansion in rats. (Am J Orthod Dentofacial Orthop 2011; 140: e31-e41)
Açıklama
Anahtar Kelimeler
Orthodontic Tooth Movement, Rapid Palatal Expansion, Distraction Osteogenesis, Experimental Periodontitis, Cancer-Chemotherapy, Midpalatal Suture, Fixed Appliances, Zoledronic Acid, Alendronate, Osteonecrosis
Kaynak
American Journal of Orthodontics and Dentofacial Orthopedics
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
140
Sayı
1
