Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study

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dc.authorwosidBabacan, Hasan/AAI-3356-2020
dc.contributor.authorOzturk, Firat
dc.contributor.authorBabacan, Hasan
dc.contributor.authorInan, Sevinc
dc.contributor.authorGumus, Cesur
dc.date.accessioned2024-08-04T20:32:53Z
dc.date.available2024-08-04T20:32:53Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: The aim of this experimental study was to evaluate the effects of systemically applied zoledronic acid on bone regeneration in response to expansion of the sagittal suture and relapse in rats. Methods: Thirty-six male Wistar rats were divided into 3 groups. In the first and second groups, saline solution was given subcutaneously after expansion, and the retention periods lasted 14 and 7 days, respectively. In the third group, 0.1 mg of zoledronic acid was diluted with saline solution and given subcutaneously after expansion; the retention period lasted for 7 days. Expansion and relapse amounts were measured by using computed tomography. After the retention period, 6 rats from each group were killed for histologic and immunohistochemical assessments. The other 6 rats from each group were used for observation of the relapse. Results: The histologic evaluation showed that, in groups 1 and 2, the numbers of osteoblasts were less than observed in group 3. When scores of staining intensity were compared, immunoreactivities were statistically significantly increased in group 3 compared with groups 2 and 1. Statistically significant differences were found when the relapse percentages were compared between the groups (P < 0.05). The smallest relapse occurred in group 3. Conclusions: Zoledronic acid has positive effects on bone formation in the sagittal suture in response to expansion and decreases the relapse ratio after expansion in rats. (Am J Orthod Dentofacial Orthop 2011; 140: e31-e41)en_US
dc.identifier.doi10.1016/j.ajodo.2010.11.020
dc.identifier.endpageE41en_US
dc.identifier.issn0889-5406
dc.identifier.issn1097-6752
dc.identifier.issue1en_US
dc.identifier.pmid21724069en_US
dc.identifier.scopus2-s2.0-79960004114en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE31en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajodo.2010.11.020
dc.identifier.urihttps://hdl.handle.net/11616/95373
dc.identifier.volume140en_US
dc.identifier.wosWOS:000292304100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrthodontic Tooth Movementen_US
dc.subjectRapid Palatal Expansionen_US
dc.subjectDistraction Osteogenesisen_US
dc.subjectExperimental Periodontitisen_US
dc.subjectCancer-Chemotherapyen_US
dc.subjectMidpalatal Sutureen_US
dc.subjectFixed Appliancesen_US
dc.subjectZoledronic Aciden_US
dc.subjectAlendronateen_US
dc.subjectOsteonecrosisen_US
dc.titleEffects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical studyen_US
dc.typeArticleen_US

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