DSpace Arşivi :: by Yazar "Bag, Harika Gozukara" değerine göre listeleniyor

Yazar "Bag, Harika Gozukara" seçeneğine göre listele

Listeleniyor 1 - 20 / 42

Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain
(Pergamon-Elsevier Science Ltd, 2018) Erdemli, Mehmet Erman; Aladag, M. Arif; Altinoz, Eyup; Demirtas, Sezin; Turkoz, Yusuf; Yigitcan, Birgul; Bag, Harika Gozukara
Objectives: The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity. Materials and methods: Four groups were formed with 9 pregnant rats each as control (C), acrylamide (AA), N-acetylcysteine (NAC), acrylamide plus N-acetylcysteine (AA plus NAC) groups. Caesarian section was implemented on the 20th day of pregnancy. Malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and Brain-derived neurotrophic factor (BDNF) levels were analyzed and histopathologic examinations were performed in brain tissues of the fetuses. Results: Our data indicated that AA caused necrotic death and hemorrhagic damages in fetal brain tissue with decreasing BNDF levels and increasing oxidative stress. N-acetylcysteine prevented the toxic effects of its on fetal brain (p < 0.05). Conclusion: Our study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect.
Acrylamide applied during pregnancy causes the neurotoxic effect by lowering bdnf levels in thefetal brain
(Pergamon-elsevıer scıence ltd, the boulevard, langford lane, kıdlıngton, oxford ox5 1gb, england, 2018) Erdemli, Mehmet Erman; Aladag, M. Arif; Altinoz, Eyup; Demirtas, Sezin; Turkoz, Yusuf; Yigitcan, Birgul; Bag, Harika Gozukara
Objectives: The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity. Materials and methods: Four groups were formed with 9 pregnant rats each as control (C), acrylamide (AA), N-acetylcysteine (NAC), acrylamide plus N-acetylcysteine (AA plus NAC) groups. Caesarian section was implemented on the 20th day of pregnancy. Malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and Brain-derived neurotrophic factor (BDNF) levels were analyzed and histopathologic examinations were performed in brain tissues of the fetuses. Results: Our data indicated that AA caused necrotic death and hemorrhagic damages in fetal brain tissue with decreasing BNDF levels and increasing oxidative stress. N-acetylcysteine prevented the toxic effects of its on fetal brain (p < 0.05). Conclusion: Our study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect.
Ameliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity
(Pergamon-Elsevier Science Ltd, 2024) Erdemli, Zeynep; Gul, Mehmet; Gokturk, Nurcan; Kayhan, Elif; Demircigil, Nursena; Ozsoy, Eda Nur; Bag, Harika Gozukara
First in the literature this study aimed to investigate the effects of Tartrazine, a common industrial food dye, on kidney and whether Thymoquinone has a protective effect in tartrazine-induced nephrotoxicity. The study conducted on the rats bred at I(center dot)non & uuml; University Experimental Animals Production and Research Center. Wistar albino rats were randomly divided into 4 groups, where each group included 8 rats: control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone groups. The experiments continued for 3 weeks and then, kidney tissues and blood samples were collected from the rats under anesthesia. Malondialdehyde (MDA), super oxidized dismutase (SOD), total oxidant status (TOS), increase in Oxidative stress index (OSI), glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase (CAT), Total antioxidant status (TAS) levels decreased in the kidney tissues collected from the tartrazine group. Serum Bun and Creatinine levels increased in the tartrazine group. Tartrazine administration damaged and degenerated the glomeruli and cortical distal tubes in the histopathology of kidney tissues, also different degrees of inflammatory cell infiltration were observed in the renal cortex and medulla. Thymoquinone and tartrazine administration improved both biochemical and histopathological parameters. Tartrazine administration induced nephrotoxicity. This could be observed with the increase in oxidant capacity and the deterioration of kidney functions. Thymoquinone was observed to demonstrate strong antioxidant properties. Thymoquinone could be used primarily as a protective agent against Tartrazine-induced toxicity.
Biochemical and histopathological investigation of the protective effects of melatonin and vitamin E against the damage caused by acetamiprid in Balb-c mouse testicles at light and electron microscopic level
(Springer Heidelberg, 2022) Zayman, Emrah; Gul, Mehmet; Erdemli, Mehmet Erman; Gul, Semir; Bag, Harika Gozukara; Taslidere, Elif
The protective effects of melatonin (Mel) and vitamin E (Vit E) against the negative effects of acetamiprid (Acmp) on testicles, reproductive hormones, and oxidative stress parameters were investigated in the present study. A total of 50 Balb-c male mice were used in 7 groups; 6 mice in the control groups (distilled water, corn oil, ethanol), and 8 in other groups (Acmp, Acmp + Mel, Acmp + Vit E, Acmp + Vit E + Mel). After the experiment, which lasted 21 days, hematoxylin eosin (H&E), periodic acid Schiff (PAS), and caspase-3 immunohistochemical (IHC) staining was performed on the testicular tissues. Also, the tissues were examined ultrastructurally with the transmission electron microscopy (TEM). In the Acmp group, there were decreased seminiferous tubule diameter and epithelial thickness, epithelial degeneration, decreased spermatozoa in the lumen, decreased PAS-positive staining in the seminiferous epithelial basement membrane, edema in the interstitial area, and hydropic degeneration in Leydig cells. Caspase-3 immunoreactivity was higher than in the other groups. TEM examination showed degeneration in tubule cells, lysosomal accumulation in cells of the spermatogenic line, vacuolizations with myelin figures, and necrosis. Hydropic degeneration, electron-dense lipid vacuoles, and chromatolysis were evident in the Leydig cell cytoplasm. In Sertoli cells, electron-dense lysosomal deposits were noted. In biochemical terms, there were decreased tissue glutathione (GSH) and total antioxidant status (TAS), and increased malondialdehyde (MDA) and total oxidant status (TOS). Plasma luteinizing hormone (LH), follicular stimulating hormone (FSH), and testosterone levels were decreased. In the groups with melatonin, vitamin E, and both were applied together, tissue damage, and apoptotic cell death were reduced at both light microscopic and ultrastructural levels. In biochemical terms, there were decreased oxidative parameters and increased hormonal parameters. It was found that vitamin E was more effective in decreasing oxidative parameters and increasing antioxidative parameters when compared to melatonin, and hormonal parameters increased at a higher level in the Acmp + Vit E group than in all groups. As a result, it was found that exposure to Acmp caused damage to testicular tissue, induced oxidative stress in testicles, and decreased plasma LH, FSH, and testosterone levels, and although vitamin E is more effective than melatonin in preventing this damage, both are effective.
Biochemical investigation of the toxic effects of acrylamide administration during pregnancy on the liver of mother and fetus and the protective role of vitamin E
(Taylor & Francis Ltd, 2017) Erdemli, Mehmet Erman; Altinoz, Eyup; Aksungur, Zeynep; Turkoz, Yusuf; Dogan, Zumrut; Bag, Harika Gozukara
Objectives: To investigate the toxic effects occurring in the liver tissues of the pregnant rats and the fetuses, which are administered acrylamide and vitamin E as a protector during pregnancy. Materials and methods: This research was conducted with the permission of Laboratory Animals Ethical Board of Inonu University Faculty of Medicine. Forty rats, of which their pregnancy is validated via vaginal smear, were distributed into five different groups. On the 20th day of pregnancy, pregnant rats and fetuses are decapitated. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS) and xanthine oxidase (XO) levels were measured in the liver samples taken from mother and fetuses. Results: It was detected that acrylamide administered during pregnancy increased MDA, TOS, XO levels statistically significantly and decreased the GSH level (p <= 0.05) in the pregnant rat liver tissue when compared to all other groups. In the vitamin E administered group; GSH, TAS levels significantly increased statistically and TOS and XO levels dropped to levels of the control group (p <= 0.05), in comparison to all other groups. Among all groups, no biochemical changes were observed in the fetus liver tissue (p > 0.05). Conclusion: The liver of pregnant rats functions as a protective pre-filter by detoxifying acrylamide effectively and the acrylamide that reaches fetus liver is detoxified by the cytochrome P-450 system of the fetus liver. To be able to figure out the biochemical mechanism, more advanced studies are needed.
Can BuCyE conditioning regimen be an alternative treatment to BEAM at autologous transplantation in malignant lymphoma patients?: a single center experience
(E-Century Publishing Corp, 2015) Berber, Ilhami; Erkurt, Mehmet Ali; Nizam, Ilknur; Koroglu, Mustafa; Kaya, Emin; Kuku, Irfan; Bag, Harika Gozukara
High-dose chemotherapy (HDC) applied together with autologous stem cell transplantation (ASCT) is a commonly used treatment modality in patients with malignant lymphoma. At present, there is a limited number of studies which compare toxicity and efficacy of various high-dose regimens applied in the treatment of malignant lymphoma. For this reason, the aim of this study was to investigate the efficacy and toxicity of BuCyE (busulfan, cyclophosphamide and etoposide) and BEAM (carmustine, etoposide, cytarabine and melphalan) preparative regimens in the patients with malignant lymphoma scheduled for autologous stem cell transplantation. Between November, 2010 and April, 2015, 42 patients with relapsed or refractory malignant lymphoma who underwent autologous stem cell transplantation following BEAM (n=11) and BuCyE (n=31) preparative regimens were analyzed at Bone Marrow Transplantation Unit of TurgutOzal Medicine Center in Turkey. The groups were compared in terms of patient characteristics, hematopoietic engraftment time, toxicity profiles and survival. No significant differences were detected between the groups with regard to age, gender distribution, international prognostic index, ASCT indications, disease status at the time of ASCT and type of lymphoma (P>0.05). Median number of infused CD34+ cells/kg, neutrophil and platelet engraftment statuses of BuCyE and BEAM groups were found to be similar (P>0.05). More patients in BuCyE group developed mucositis and nausea, but this difference was not statistically significant (P>0.05). A similar statistically insignificant difference was seen in that infectious complications occurred more commonly in BEAM group (P>0.05). Overall survival and event-free survival rates were not significantly different between the groups (P>0.05). BuCyE is a conditioning regimen which can be effectively used as an alternative to BEAM in the patients with malignant lymphoma undergoing ASCT. Moreover, toxicity rates of both regimens are similar. In order to comprehend the effect of each HDC regimen, further evidence-based data obtained from the studies involving larger sample sizes are required.
Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?
(Mashhad Univ Med Sciences, 2018) Erdemli, Mehmet Erman; Gul, Mehmet; Altinoz, Eyup; Aksungur, Zeynep; Gul, Semir; Bag, Harika Gozukara
Objective(s): To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride. Materials and Methods: Ethics committee approval was obtained and 50 male Wistar rats were randomly divided into 5 groups that included 10 rats each: Control, Corn oil, Crocin, Carbon tetrachloride (CCl4), and Crocin + Carbon tetrachloride. Following the experiments, the rats were decapitated under anesthesia and incised kidney tissues were subjected to biochemical and histological examinations. Results: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P <= 0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman's space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. There was a significant decrease in increased MDA, TOS, Bun, and creatinine levels, and a significant increase in decreased GSH, SOD, CAT, and TAS levels in CCl4 + crocin administered group compared to the CCl4 group (P <= 0.05), local minimal glomerular damage, tubular damage, inflammatory infiltration, and vascular collagen symptoms were observed in kidney sections, however significant improvement was observed in damage findings when compared to the CCl4 group. Conclusion: At this dose and time interval, against a highly toxic chemical such as CCl4, crocin was able to suppress oxidative stress by playing a protective role in the kidney tissue.
Chronic liver fibrosis induction in aging causes significant ultra-structural deterioration in liver and alteration on immune response gene expressions in liver-spleen axis
(Taylor & Francis Inc, 2024) Karaca, Zeynal Mete; Karaca, Gamze; Kayhan, Basak; Gul, Mehmet; Ersan, Veysel; Bag, Harika Gozukara; Yesilada, Elif
The relationship between damage to the liver and spleen by aging and the immune response status in these two organs, which are anatomically and immunologically interconnected, is unknown. The authors investigated the histopathological, ultrastructural, and immunological effects of aging in young and aged fibrotic mice by using an experimental model. Four groups were planned, with 10 mice in each experimental group. The levels of fibrosis and ultrastructural destruction in the liver were determined by alpha-SMA staining and TEM analysis. Expression levels of immunity genes (Il2, Il4, Il6, Il10, Il12, Il17, Tnf, Ifng, Tgfb1, Gata3, Rorc, Tbx21, Foxp3, Ccl2, Ccr2, Cxcr3, Pf4, Cxcl10) were carried out by qRT-PCR. While structural disorders were detected in the mitochondria of aged healthy group, cellular destruction in the fibrosis-induced elderly group was at a dramatic level. Fibrosis induction in aged mice caused an elevation in the expression of chemokines (CCl2, CXCL10, CCR2) and cytokine (IL-17a) genes that induce autoinflammatory response in the liver. Unlike the cellular pathology and genes activated in fibrosis in youth and the natural occurrence of fibrosis with aging, induction of fibrosis during aging causes deterioration in the liver and expression of genes responsible for autoimmunity in both the liver and spleen.
Clinical Performance of Nanofilled and Microhybrid Direct Composite Restorations on Endodontically Treated Teeth
(Dennis Barber Ltd, 2019) Akalin, Tugba Toz; Bozkurt, Funda Ozturk; Tuncer, Aysun Kara; Bag, Harika Gozukara; Ozcan, Mutlu
This study evaluated the clinical performance of direct restorations made of nanofilled and microhybrid resin composites in endodontically treated teeth. Twenty patients (11 males, 9 females; mean age: 34.2 +/- 10) that met the inclusion criteria received a total of 48 restorations. After employing etch-and-rinse adhesive system, one dentist placed all restorations using either a nanofilled (Filtek Ultimate) or microhybrid (Filtek Z250) resin composite. The restorations were clinically reviewed at baseline, 6 months, and up to 2 years using the modified United States Public Health Service (USPHS) criteria. The changes were analyzed using the McNemar test and marginal homogeneity tests (p< 0.05). The mean observation period was 17.4 months. With respect to color match, marginal adaptation, secondary caries, and surface texture, no significant differences were found between the two restorative materials (p> 0.05). Most restorations yielded alpha or bravo scores with respect to the evaluation criteria. Five restorations failed due to chipping up to 2 years (1 microhybrid at 6 m, and 3 at 2 years; 1 nanofilled at 2 y) and were repaired. One complete replacement and one extraction due to endodontic complications were needed for 2 microhybrid resin group at 2 years.
A Combination of Blood Lymphocytes and AST Levels Distinguishes Patients with Small Hepatocellular Carcinomas from Non-cancer Patients
(Springer, 2021) Carr, Brian, I; Bag, Harika Gozukara; Ince, Volkan; Akbulut, Sami; Ersan, Veysel; Usta, Sertac; Isik, Burak
Purpose HCC patients typically present at an advanced tumor stage, in which surgical therapies cannot be used. Screening ultrasound exams can increase the numbers of patients diagnosed with small tumors, but are often not used in patients at risk for HCC. We evaluated clinically available and cheap potential blood tests as biomarkers for screening patients at risk for HCC. Methods A comparison was made of commonly used blood count and liver function parameters in a group of patients (n = 101) with small HCCs (<= 3 cm) or without HCC (n = 275), who presented for liver transplantation in our institute. Results Significant differences were found for blood lymphocytes and AST levels. This 2-parameter combination was found to be significantly different between patients with small HCCs versus no HCC. Using the combination of lymphocytes and AST levels to dichotomize the HCC patients, only blood levels of alpha-fetoprotein among the tumor characteristics were found to be significantly different among the 2 HCC groups, as well as levels of blood total bilirubin, ALKP, and PLR ratio. The results were confirmed using a separate smaller cohort of non-transplanted small size HCC patients. Conclusion The combination of elevated blood levels of lymphocyte counts and AST levels holds promise for screening of patients with chronic liver disease who are at risk for HCC.
Crocin (active constituent of saffron) improves CCl4-induced liver damage by modulating oxidative stress in rats
(Walter De Gruyter Gmbh, 2019) Cosgun, Binnaz Elif; Erdemli, Mehmet Erman; Gul, Mehmet; Gul, Semir; Bag, Harika Gozukara; Erdemli, Zeynep; Altinoz, Eyup
Background: CCl4 is a widely used xenobiotic for the purpose of causing liver damage in experimental studies. In this study, we aimed to reveal the effects of crocin on liver injury caused by CCl4 via free radical scavenging properties. Materials and methods: Animals were divided into five groups of 10: control; corn oil; crocin; CCl4 ; CCl4 + crocin. Tissue samples were carefully removed and separated for biochemical and histological investigations. Results: CCl4 administration led to significant increases in MDA, SOD, CAT and TOS in liver tissue, and AST, ALT and ALP levels in plasma (p <0.05). In addition, CCl4 caused significant decreases in GSH and TAS (p < 0.05). When animals were treated with crocin, high MDA, SOD, CAT, TOS levels, and AST and ALP activities decreased and GSH and TAS levels increased. Control group exhibited normal histological appearance; however extensive necrosis areas were detected in the CCl4 group. In the CCl4 +crocin group, pathological changes were markedly decreased and the appearance of liver tissue was almost similar to the control groups. Conclusion: Our results showed that crocin suppresses oxidative stress with antioxidant properties and has a protective effect on tissue damage caused by CCl4.
DHAP plus filgrastim as an effective peripheral stem cell mobilization regimen for autologous stem-cell transplantation in patients with relapsed/refractory lymphoma: A single center experience
(Pergamon-Elsevier Science Ltd, 2016) Berber, Ilhami; Erkurt, Mehmet Ali; Kuku, Irfan; Maya, Emin; Bag, Harika Gozukara; Nizam, Ilknur; Koroglu, Mustafa
This study aimed to evaluate the efficiency of DHAP regimen plus filgrastim for mobilization of stem cells in patients with recurrent and/or refractory lymphoma. Thirty-four patients who took DHAP as salvage therapy prior to autologous stem cell transplantation were included. After chemotherapies, 2 cycles of DHAP plus filgrastim were administered to the patients. Stem cells from 32 patients (94%) were collected on median 11th day (8-12), and the median collected CD34(+) cell dose was 9.7 x 10(6)/kg (range 3.8-41.6). DHAP plus filgrastim was found to be an effective chemotherapy regimen in mobilizing CD34(+) stem cells into the peripheral. (c) 2016 Elsevier Ltd. All rights reserved.
The effect of bulk-fill flowable composites on the fracture resistance and cuspal deflection of endodontically treated premolars
(Taylor & Francis Ltd, 2015) Toz, Tugba; Tuncer, Safa; Bozkurt, Funda Ozturk; Tuncer, Aysun Kara; Bag, Harika Gozukara
The aim of this study was to evaluate the effect of bulk-fill flowable composites on cuspal deflection and fracture resistance of endodontically treated teeth. Forty-two maxillary premolars were subjected to endodontic treatment followed by the preparation of mesioocclusodistal cavities. Teeth were divided into six groups according to restorative materials as follows: Group 1: Clearfil Majesty Flow and Clearfil Majesty Posterior; Group 2: Venus Bulk Fill and Clearfil Majesty Posterior; Group 3: Clearfil Majesty Posterior; Group 4: Vertise Flow and Clearfil Majesty Posterior; Group 5: SDR and Clearfil Majesty Posterior; and Group 6: x-tra base and Clearfil Majesty Posterior. A single-step self-etch adhesive (OptiBond All-in-One) was applied to all groups, except Group 4. The cavities were restored with a centripetal incremental insertion technique and flowable composites using a 2-mm-thick base material, except for Group 3. The distance between cusp tips was measured before and after the cavity preparations, after the restorations, and after thermal cyclus with a digital micrometer. After measuring, each tooth was subjected to compressive loading with a stainless steel ball (4mm diameter) perpendicular to the occlusal surface with a crosshead speed of 1mm/min, and mean loads necessary to fracture were recorded in Newtons. The data were statistically analyzed by Kruskal-Wallis test. No statistically significant differences were found between groups in fracture strength or cuspal deflections (p>0.05). Bulk-fill flowable composite bases did not change the cuspal deflection or fracture resistance of endodontically treated teeth, compared with that of a conventional flowable base and conventional resin composite.
The Effect of Pre-transplant Lipid Profile on Post-transplant Hepatocellular Carcinoma Recurrence: Retrospective Single-Center Analysis
(Aves, 2022) Ince, Volkan; Carr, Brian, I; Usta, Sertac; Ersan, Veysel; Bag, Harika Gozukara; Yilmaz, Sezai
Background: Plasma lipids have been shown to relate to tumor biology. We aimed to analyze the effect of pre-transplant plasma lipid profiles on post-transplant tumor recurrence in patients with hepatocellular carcinoma and to identify any possible relationship between the pre-transplant lipid profile with maximum tumor diameter, number of tumor nodules, tumor differentiation, portal vein invasion, or serum biomarker levels. Methods: Patients with hepatocellular carcinoma who underwent liver transplants between 2006 and 2021 had data collected prospectively and were analyzed retrospectively. Patients who did not have lipid profile data before transplant and whose post-transplant follow-up period was <90 days were excluded. Patients who had pre-transplant plasma lipid data and whose post-transplant follow-up period was >90 days were included in this study (n = 254). Results: Lower high-density lipoprotein cholesterol levels were found to be significantly associated with post-Tx recurrence (38 vs 29.5, P <.001) and were also significantly associated with macroscopic portal vein thrombosis (39 vs 30.4, P <.021). There was no significant association between plasma lipids and tumor differentiation. Higher high-density lipoprotein cholesterol levels were significantly associated with good overall and disease-free survivals (P =.024 and P =.001). Conclusion: Pre-transplant low plasma high-density lipoprotein cholesterol levels were significantly associated with portal vein thrombosis and poor post-transplant overall and disease-free survivals.
The effects of acrylamide and Vitamin E administration during pregnancy on adult rats testis
(Wiley, 2019) Erdemli, Zeynep; Erdemli, Mehmet Erman; Turkoz, Yusuf; Gul, Mehmet; Yigitcan, Birgul; Bag, Harika Gozukara
Thirty rats, with confirmed pregnancies by vaginal smear, were divided into five groups, each including six rats, as the Control, Corn Oil, Vitamin E, Acrylamide, Vitamin E + Acrylamide groups. The births were monitored on the 21st day to select the male rats, and the selected male rats were decapitated at the end of the 8th week. Oxidant-antioxidant parameters, serum hormone levels and histopathological examinations were performed on testis tissues of the rats. It was found that acrylamide (AA) negatively affected the serum hormone levels (Total Testosterone, Progesterone, FSH, LH, Estradiol), oxidant-antioxidant parameters in the tissues (MDA, GSH, NO, SOD, CAT, TAS, TOS) (p < 0.05) and the histological findings (the Johnson's score, seminiferous tubule diameter, histopathological images), and Vitamin E administration resulted with an increase in the total testosterone, progesterone, FSH, LH, GSH, TAS, NO, SOD, CAT levels (p < 0.05) and an improvement in histopathological findings. Currently, it is almost inevitable to be exposed to food-induced AA toxicity and such toxicity is likely to cause lifelong damage. It was concluded that Vitamin E was able to present a protective effect in the testis tissue against AA toxicity; however, further studies are necessary.
The effects of acrylamide and vitamin E on kidneys in pregnancy: an experimental study
(Taylor & Francis Ltd, 2019) Erdemli, Mehmet Erman; Aksungur, Zeynep; Gul, Mehmet; Yigitcan, Birgul; Bag, Harika Gozukara; Altinoz, Eyup; Turkoz, Yusuf
Objectives: The objective of this study is to investigate possible damages to kidney tissues of pregnant rats and their fetuses exposed to acrylamide during pregnancy and possible protective effects of vitamin E against these damages. Material and methods: Rats were randomly assigned to five groups of control, corn oil, vitamin E, acrylamide, vitamin E + acrylamide, six pregnant rats in each. Mother and fetal kidney tissues were examined for malondialdehyde (MDA), reductase glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS), total oxidant status (TOS), urea, creatine, trace elements such as Zn and Cu in the serum and histopathological analyses were conducted. Results: It was determined that acrylamide, administered during pregnancy, statistically significantly increased MDA and TOS levels, maternal serum urea, creatinine, and Zn levels, while it decreased GSH, TAS, SOD, and CAT levels (p <= .05) when compared with all other groups in the kidney tissues of pregnant rats and their fetuses and caused tubular degeneration, hemorrhage, narrowing, and closure in Bowman's space, and, in the E vitamin group, it statistically significantly increased GSH, TAS, SOD, CAT, urea, creatinine, and Zn levels when compared with other groups and lowered TOS and MDA levels to those of the control group (p < .05) and there were no differences between the groups histologically. Conclusion: It was observed that acrylamide administered during pregnancy caused oxidative stress in kidney tissues of mother rats and their fetuses, resulting in tissue damage, and vitamin E application, which is considered to be a powerful antioxidant, inhibited oxidative stress.
Effects of high-voltage electrical burns and other burns on levels of serum oxidative stress and telomerase in children
(2018) Gurunluoglu, Kubilay; Demircan, Mehmet; Tasci, Aytac; Uremia, Muhammed Mehdi; Turkoz, Yusuf; Bag, Harika Gozukara
Introduction: Electrical burns cause significant morbidity and mortality worldwide. Here we measured changes in levels of serum oxidative stress and telomerase in children suffering from high-voltage electrical burn (HVEB) injuries and other burns and the significance of these parameters in terms of amputation. Materials and methods: After obtaining approval from our ethics committee for this prospective study, we formed three groups: a group of 18 children with HVEBs, a group of 18 children with thermal burns, and a control group. All children were 1-16 years of age. The HVEB group was divided into HVEB-WA (without amputation) and HVEB-A (with amputation) subgroups. Serum malondialdehyde (MDA) level, total antioxidant capacity (TAC), total oxidant capacity (TOC), glutathione (GSH) level, and telomerase level were measured and compared among the groups. Results: The patients differed in terms of demographics. The healing time of the HVEB group was longer than that of the thermal burn group, and the oxidative stress indicators of the HVEB group remained higher for longer. The mean oxidative stress indices in the HVEB-A group were higher than those in the HVEB-WA group and remained elevated for longer. Conclusion: HVEBs are more destructive than thermal burns; damage may progress over time, and healing takes longer. Healing can be followed biochemically by measuring levels of oxidative stress indicators. Indications for amputation, if not initially obvious, can be predicted by evaluating these indicators, affording therapeutic advantages. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.
Effects of high-voltage electrical burns and other burns on levels of serum oxidative stress and telomerase in children
(Elsevier Sci Ltd, 2018) Gurunluoglu, Kubilay; Demircan, Mehmet; Tasci, Aytac; Uremia, Muhammed Mehdi; Turkoz, Yusuf; Bag, Harika Gozukara
Introduction: Electrical burns cause significant morbidity and mortality worldwide. Here we measured changes in levels of serum oxidative stress and telomerase in children suffering from high-voltage electrical burn (HVEB) injuries and other burns and the significance of these parameters in terms of amputation. Materials and methods: After obtaining approval from our ethics committee for this prospective study, we formed three groups: a group of 18 children with HVEBs, a group of 18 children with thermal burns, and a control group. All children were 1-16 years of age. The HVEB group was divided into HVEB-WA (without amputation) and HVEB-A (with amputation) subgroups. Serum malondialdehyde (MDA) level, total antioxidant capacity (TAC), total oxidant capacity (TOC), glutathione (GSH) level, and telomerase level were measured and compared among the groups. Results: The patients differed in terms of demographics. The healing time of the HVEB group was longer than that of the thermal burn group, and the oxidative stress indicators of the HVEB group remained higher for longer. The mean oxidative stress indices in the HVEB-A group were higher than those in the HVEB-WA group and remained elevated for longer. Conclusion: HVEBs are more destructive than thermal burns; damage may progress over time, and healing takes longer. Healing can be followed biochemically by measuring levels of oxidative stress indicators. Indications for amputation, if not initially obvious, can be predicted by evaluating these indicators, affording therapeutic advantages. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.
Effects of Noopept on Pubertal Process in Streptozosin-induced Diabetic Prepubertal Rats
(Wiley, 2017) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Kaya, Gul Busra; Bag, Harika Gozukara; Taslidere, Asli Cetin; Gul, Ceren
[Abstract Not Available]
EFFECTS OF RENAL REPLACEMENT THERAPY ON FIBROMYALGIA SYNDROME IN PATIENTS WITH CHRONIC KIDNEY DISEASE
(Carbone Editore, 2018) Berber, Ilhami; Sahin, Idris; Gorgel, Ahmet; Cagin, Yasir Furkan; Bag, Harika Gozukara; Berber, Nurcan Kirici
Introduction: Although musculoskeletal disorders are among the major complications of chronic kidney disease (CKD), there are scarce data to investigate fibromyalgia syndrome (FMS) in these patients. We aimed to investigate the prevalence of FMS in the patients with CKD. Material and methods: A total of 289 (119 predialysis (PD), 85 hemodialysis (HD), 85 continuous ambulatory peritoneal dialysis (CAPD)) patients were included. Diagnosis of FMS was based on American College of Rheumatology (ACR) 1990 FMS criteria. Results: Mean age was 52 +/- 16 years (range 18-89 years). One-hundred-sixty-four (56.7%) of them were male. A total of 46 patients (10 male/36 female) (15.9%) were diagnosed FMS. The prevalence of FMS was 28.8% in females and 6.1% in males. Compared to males, females had a significantly higher rate of FMS (p<0.001). The prevalence of FMS was 19.3% in PD group, 17.6% in the CAPD group, and 9.4% in the HD group. Although the frequency of FMS was lower in HD group compared to both the PD and the CAPD groups, the differences were not statistically significant (for HD vs PD, p=0.052; for HD vs CAPD, p=0.113). In PD group, hemoglobin (Hb) levels were significantly higher in patients with FMS than without FMS. Parathormone (PTH) levels were significantly lower in CAPD patients with FMS than without FMS. Although the prevalence of FMS was increased in PD and CAPD patients, this increase did not reach statistical significance. FMS was markedly more prevalent in female patients. While the Hb level was lower in the PD patients with FMS, PTH level was lower in the CAPD patients diagnosed with FMS. Conclusions: Our study demonstrated that the rate of FMS was higher in PD and CAPD patients compared to HD patients, although our results did not reach statistical significance. Among the entire demographic and laboratory parameters, female gender was found to be significant risk factor for development of FMS. Future multicenter studies which have large sample size are clearly needed to determine other factors related to development of FMS in patients with CKD.

Yazar "Bag, Harika Gozukara" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri