Crocin (active constituent of saffron) improves CCl4-induced liver damage by modulating oxidative stress in rats
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: CCl4 is a widely used xenobiotic for the purpose of causing liver damage in experimental studies. In this study, we aimed to reveal the effects of crocin on liver injury caused by CCl4 via free radical scavenging properties. Materials and methods: Animals were divided into five groups of 10: control; corn oil; crocin; CCl4 ; CCl4 + crocin. Tissue samples were carefully removed and separated for biochemical and histological investigations. Results: CCl4 administration led to significant increases in MDA, SOD, CAT and TOS in liver tissue, and AST, ALT and ALP levels in plasma (p <0.05). In addition, CCl4 caused significant decreases in GSH and TAS (p < 0.05). When animals were treated with crocin, high MDA, SOD, CAT, TOS levels, and AST and ALP activities decreased and GSH and TAS levels increased. Control group exhibited normal histological appearance; however extensive necrosis areas were detected in the CCl4 group. In the CCl4 +crocin group, pathological changes were markedly decreased and the appearance of liver tissue was almost similar to the control groups. Conclusion: Our results showed that crocin suppresses oxidative stress with antioxidant properties and has a protective effect on tissue damage caused by CCl4.
Açıklama
Anahtar Kelimeler
CCl4, Crocin, Oxidative stress, MDA, Hepatotoxicity
Kaynak
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
44
Sayı
3
