Crocin (active constituent of saffron) improves CCl4-induced liver damage by modulating oxidative stress in rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidAltinoz, Eyup/AAM-2378-2020
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorCosgun, Binnaz Elif
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorGul, Semir
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorAltinoz, Eyup
dc.date.accessioned2024-08-04T20:09:59Z
dc.date.available2024-08-04T20:09:59Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: CCl4 is a widely used xenobiotic for the purpose of causing liver damage in experimental studies. In this study, we aimed to reveal the effects of crocin on liver injury caused by CCl4 via free radical scavenging properties. Materials and methods: Animals were divided into five groups of 10: control; corn oil; crocin; CCl4 ; CCl4 + crocin. Tissue samples were carefully removed and separated for biochemical and histological investigations. Results: CCl4 administration led to significant increases in MDA, SOD, CAT and TOS in liver tissue, and AST, ALT and ALP levels in plasma (p <0.05). In addition, CCl4 caused significant decreases in GSH and TAS (p < 0.05). When animals were treated with crocin, high MDA, SOD, CAT, TOS levels, and AST and ALP activities decreased and GSH and TAS levels increased. Control group exhibited normal histological appearance; however extensive necrosis areas were detected in the CCl4 group. In the CCl4 +crocin group, pathological changes were markedly decreased and the appearance of liver tissue was almost similar to the control groups. Conclusion: Our results showed that crocin suppresses oxidative stress with antioxidant properties and has a protective effect on tissue damage caused by CCl4.en_US
dc.description.sponsorshipKarabuk University scientific research fund [KBU-BAP-15/2-YL-009]en_US
dc.description.sponsorshipThis study was supported financially by Karabuk University scientific research fund (KBU-BAP-15/2-YL-009).en_US
dc.identifier.doi10.1515/tjb-2017-0173
dc.identifier.endpage378en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85073551074en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage370en_US
dc.identifier.trdizinid335443en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2017-0173
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/335443
dc.identifier.urihttps://hdl.handle.net/11616/92546
dc.identifier.volume44en_US
dc.identifier.wosWOS:000481592100016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCCl4en_US
dc.subjectCrocinen_US
dc.subjectOxidative stressen_US
dc.subjectMDAen_US
dc.subjectHepatotoxicityen_US
dc.titleCrocin (active constituent of saffron) improves CCl4-induced liver damage by modulating oxidative stress in ratsen_US
dc.typeArticleen_US

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