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Öğe The role of National Institutes of Health category IV prostatitis in accurately staging the newly diagnosed prostate cancer(Springer London Ltd, 2013) Aglamis, E.; Tasdemir, C.; Ceylan, C.It has been known that the National Institutes of Health category IV (NIH-IV) prostatitis increases the serum total prostate-specific antigen (tPSA) in patients with benign prostatic hyperplasia. However, the effect of NIH-IV prostatitis on tPSA levels, which are used for staging prostate cancer (PCa) in patients with PCa, has not been previously investigated. To evaluate the effect of NIH-IV prostatitis on the tPSA which is used for staging PCa in patients with newly diagnosed PCa. A total of 198 patients in whom PCa was detected were included in the study. Group 1 included patients with only PCa, while Group 2 included patients with prostatitis and PCa. The tPSA levels of patients in Groups 1 and 2 were compared. A total of 120 (61 %) PCa (Group 1) and 78 (39 %) PCa + NIH-IV prostatitis (Group 2) patients were identified. The tPSA levels of 70 (58 %) patients in Group 1 and 22 (28 %) patients in Group 2 were at the interval of < 20 ng/ml (the mean levels of tPSA: 11.8 +/- A 4.5 and 14.1 +/- A 3.3, respectively). The tPSA levels of 50 (42 %) patients in Group 1 and 56 (72 %) patients in Group 2 were within the range of a parts per thousand yen20 ng/ml (the mean levels of tPSA: 39.9 +/- A 31.0 and 47.0 +/- A 29.2, respectively). Within both the < 20 ng/ml range and a parts per thousand yen20 ng/ml range, the mean tPSA value in Group 2 was found to be significantly higher than that of Group 1 (p = 0.03 and 0.01, respectively). The existence of NIH-IV prostatitis together with cancer in patients with PCa significantly increases the tPSA level which is used in staging the PCa.