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  • Küçük Resim
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    The association of GLUT-1, Galectin 3 and Claudin 1 staining with the type of renal tumors
    (2019) Turna, Seval; Coban, Ganime; Yildiz, Pelin; Unver, Nurcan; Buyukpinarbasili, Nur; Ersoz, Cevper; Gucin, Zuhal
    Aim: The mechanism of carcinogenesis and prognostic parameters of renal cell carcinomas(RCC) exhibiting an increasing incidence trend are still obscure. Even though new tumors types are identified, diagnostic difficulty is even experienced occasionally for the most common tumor types. Various immunohistochemical and molecular-genetic studies are conducted for tumor type identification and prognostic evaluation. The present study examined glucose transporter protein (GLUT-1), galectin-3 that is associated with cell growth, differentiation, proliferation, adhesion, angiogenesis and apoptosis, and Claudin 1, a transmembrane protein of intercellular tight junctions, immunohistochemically for the most commonly encountered renal tumors. The staining patterns were compared in terms of Fuhrman nuclear grade, stage, metastasis, and demographic data. Material and Methods: Methods: The study consisted of a total of 99 renal tumor cases including 40 Clear Cell Renal Cell Carcinoma (CCRCC), 22 Chromophobe Renal Cell Carcinoma (CrRCC), 16 Oncocytoma and 19 Papillary Renal Cell Carcinoma (PRCC) cases. Results: Overexpression of GLUT-1 was observed in 92.5% of CCRCC cases and 36.8% of PRCC cases whereas the loss of expression was observed in CrRCC and Oncocytoma. Claudin-1 was seen in 77.5% of the CCRCCs, 45.4% of the CrRCCs, 81.25% of the oncocytomas and 84.2% of the PRCCs. Galectin-3 was present in 90% of the CCRCCs, 81% of the CrRCCs, 50% of the oncocytomas and 21% of the PRCC Conclusion: Diffuse membranous staining pattern was observed for GLUT-1 in case of CCRCC, however, no correlation with prognostic parameters was noticed. Claudin-1 expression was observed in high nuclear grade tumors. Thus, it may be regarded as a poor prognostic factor. Galectin 3 expression was observed in the tumors with sarcomatoid differentiation.
  • Küçük Resim
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    Clinical and histopathological analysis of 1694 cases diagnosed with endometrial polyps based on endometrial sampling
    (2019) Sahin, Nurhan; Coban, Ganime; Sezal, Zeynep; Kilic, Gokhan; Cali, Halime; Arici, Dilek Sema
    Aim: All the patients presented to gynecology polyclinics with abnormal uterine bleeding either during the reproductive or the peri/ postmenopausal period underwent endometrial sampling to exclude endometrial pathologies. One endometrial pathology frequently encountered in the histopathological examination of these samples is Endometrial Polyp (EP); and it is important that they are recognized as they require a distinct treatment plan and can be associated with endometrial malignancies. Material and Methods: In this study, we investigated the demographic and clinical findings and concomitant malignancies of the cases diagnosed with endometrial polyps based on endometrial biopsy samples at Bezmialem Vakif University over a period of 7 years and compared our results with those in the literature. Results: Our study determined an EP prevalence of 19% and only 11 (0.65%) of the 1694 cases were found to have “adenocarcinomas” within/outside the polyp. Conclusion: Considering that EPs may be associated with malignancies, histopathological examination must absolutely be performed with adequate sampling.