The association of GLUT-1, Galectin 3 and Claudin 1 staining with the type of renal tumors
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The mechanism of carcinogenesis and prognostic parameters of renal cell carcinomas(RCC) exhibiting an increasing incidence
trend are still obscure. Even though new tumors types are identified, diagnostic difficulty is even experienced occasionally for the
most common tumor types. Various immunohistochemical and molecular-genetic studies are conducted for tumor type identification
and prognostic evaluation. The present study examined glucose transporter protein (GLUT-1), galectin-3 that is associated with cell
growth, differentiation, proliferation, adhesion, angiogenesis and apoptosis, and Claudin 1, a transmembrane protein of intercellular
tight junctions, immunohistochemically for the most commonly encountered renal tumors. The staining patterns were compared in
terms of Fuhrman nuclear grade, stage, metastasis, and demographic data.
Material and Methods: Methods: The study consisted of a total of 99 renal tumor cases including 40 Clear Cell Renal Cell Carcinoma
(CCRCC), 22 Chromophobe Renal Cell Carcinoma (CrRCC), 16 Oncocytoma and 19 Papillary Renal Cell Carcinoma (PRCC) cases.
Results: Overexpression of GLUT-1 was observed in 92.5% of CCRCC cases and 36.8% of PRCC cases whereas the loss of expression
was observed in CrRCC and Oncocytoma. Claudin-1 was seen in 77.5% of the CCRCCs, 45.4% of the CrRCCs, 81.25% of the
oncocytomas and 84.2% of the PRCCs. Galectin-3 was present in 90% of the CCRCCs, 81% of the CrRCCs, 50% of the oncocytomas
and 21% of the PRCC
Conclusion: Diffuse membranous staining pattern was observed for GLUT-1 in case of CCRCC, however, no correlation with
prognostic parameters was noticed. Claudin-1 expression was observed in high nuclear grade tumors. Thus, it may be regarded as
a poor prognostic factor. Galectin 3 expression was observed in the tumors with sarcomatoid differentiation.
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Medical Research
WoS Q DeÄŸeri
Scopus Q DeÄŸeri
Cilt
Sayı
Künye
Coban, G., Turna, S., Yildiz, P., Unver, N., Buyukpinarbasili, N., Ersoz, C., & Gucin, Z. (2021). The association of GLUT-1, Galectin 3 and Claudin 1 staining with the type of renal tumors . Annals of Medical Research
