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Öğe Acute Abdominal Pain With Rupture Of Uterine Leimyosarcoma(Lippincott Williams & Wilkins, 2016) Coskun, Ebru Inci; Yilmaz, Ercan; Sahin, Nurhan[Abstract Not Available]Öğe Assessment of levels of knowledge of breastfeeding counseling of health personnel working in primary health care institutions(2019) Kayhan Tetik, Burcu; Aksoy Derya, Yeşim; Ucar, Tuba; Coskun, Ebru Inci; Felek, Selma; Citil, Semsettin; Sener, Kemal;Aim: The aim of this study is to evaluate the knowledge level of breast milk and breastfeeding of health professionals working in primary health care institutions in Malatya.Material and Methods: A Cross-sectional Study’s survey prepared by using the Handbook of Breastfeeding Counseling translated by Child and Adolescent Reproductive Health Branch of the Ministry of Health of Turkey. 778 people were contacted by the interviewers by visiting the primary health care institutions in Malatya city center and districts, directly. All data was evaluated with SPSS 22 software and p0.05 was accepted as statistically significant.Results: The mean age of the participants was 36.15±8.57 years; 77.6% of them were women; 49.1% were working in Family Health Center. It was determined 80.1% of family physicians and 84.5% of midwives / nurses have been consulting about breast milk / breastfeeding in daily practice. When the respondents’ answers to the statements of knowledge about breast milk/breastfeeding counseling were assessed, there was no significant difference between the answers given by the family physicians and midwives/ nurses (p> 0.05). The participants gave wrong answers to 40% of the questions about conditions that require practical support such as insufficient breastmilk and the conditions related to the breasts. Conclusion: In our study we observed that basic subjects were well known by healthcare personnel whereas there is a serious lack of information, especially in daily practice, which should be constantly updated. We think that the training of breastfeeding and breastfeeding counseling should be updated periodically and especially emphasis should be given to new developments and practical information.Öğe Assessment of relationships between novel inflammatory markers and presence and severity of preeclampsia: Epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratio(Taylor & Francis Inc, 2017) Cakmak, Huseyin Altug; Cakmak, Burcu Dincgez; Yayla, Cigdem Abide; Coskun, Ebru Inci; Erturk, Mehmet; Keles, IbrahimObjective: The aim of this study was to evaluate the relation of three new inflammatory markers with presence and severity of preeclampsia and to compare the predictive values of all markers for presence of this setting.Methods: In this study, a total of 100 consecutive pregnants with a diagnosis of preeclampsia and 40 healthy pregnants between October 2014 and April 2015 were included. Epicardial fat tissue was calculated by two-dimensional transthoracic echocardiography, and pentraxin-3 and neutrophil-to-lymphocyte ratio were measured by using an enzyme-linked immunosorbent assay method and routine blood count analysis, respectively.Results: Epicardial fat thickness (p<0.001), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were found to be significantly increased in the preeclampsia as compared to the healthy pregnants. Furthermore, epicardial fat thickness (p=0.002), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were significantly elevated in the severe preeclampsia compared to mild preeclampsia. In the multivariate analysis, epicardial fat thickness (p=0.013), pentraxin-3 (p=0.04), and neutrophil-to-lymphocyte ratio (p<0.001) were found as significant independent predictors of presence of preeclampsia after adjusting for other risk factors.Conclusion: Epicardial fat thickness, neutrophil-to-lymphocyte ratio, and pentraxin-3 are important markers that provide an additional information beyond that provided by conventional methods in predicting presence and severity of preeclampsia.Öğe Assessment of relationships between novel inflammatory markers and presence and severity ofpreeclampsia: epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratio(Taylor & francıs ınc, 530 walnut street, ste 850, phıladelphıa, pa 19106 usa, 2017) Coskun, Ebru Inci; Erturk, MehmetObjective: The aim of this study was to evaluate the relation of three new inflammatory markers with presence and severity of preeclampsia and to compare the predictive values of all markers for presence of this setting.Methods: In this study, a total of 100 consecutive pregnants with a diagnosis of preeclampsia and 40 healthy pregnants between October 2014 and April 2015 were included. Epicardial fat tissue was calculated by two-dimensional transthoracic echocardiography, and pentraxin-3 and neutrophil-to-lymphocyte ratio were measured by using an enzyme-linked immunosorbent assay method and routine blood count analysis, respectively.Results: Epicardial fat thickness (p<0.001), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were found to be significantly increased in the preeclampsia as compared to the healthy pregnants. Furthermore, epicardial fat thickness (p=0.002), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were significantly elevated in the severe preeclampsia compared to mild preeclampsia. In the multivariate analysis, epicardial fat thickness (p=0.013), pentraxin-3 (p=0.04), and neutrophil-to-lymphocyte ratio (p<0.001) were found as significant independent predictors of presence of preeclampsia after adjusting for other risk factors.Conclusion: Epicardial fat thickness, neutrophil-to-lymphocyte ratio, and pentraxin-3 are important markers that provide an additional information beyond that provided by conventional methods in predicting presence and severity of preeclampsia.Öğe The effect of motivational video and nutrition on the non-stress test: a randomised controlled clinical trial(Taylor & Francis Inc, 2022) Tashan, Sermin Timur; Coskun, Ebru Inci; Nacar, Gulcin; Erci, BehiceThis study aimed to determine the effect of motivational video stimulation and nutrition on the non-stress test (NST). The sample of the study consisted of 360 pregnant women in total, including two experimental groups and one control group (120 pregnant women in each group). After the pregnant women in the study were divided into three groups at a 1:1:1 ratio with the computer-assisted random sampling method, the draw method was used to determine the experimental and control groups. The pregnant women in the first experimental group were allowed to consume cake and juice 30 min before the NST procedure. The pregnant women in the second experimental group were also allowed to consume cake and juice, while they were also shown a video with the content of development and changes in the mother and the foetus during pregnancy, with relaxing music, for about 15-20 min. There was no intervention made in the control group. The data were collected using a Participant Information Form and an NST Findings Registry Form which were created by the researchers based on their review of the relevant literature. The data were analysed using arithmetic means, percentage distributions, ANOVA, Bonferroni and chi-squared tests. It was found that the mean number of foetal movements and the mean number of accelerations in the cake + juice and motivational video groups were higher than those in the control group (p < 0.001). Besides, the pregnant women in the experimental groups were found to have more reactive NST results. As a result, it was determined that the motivational video and cake + juice interventions improved the movement of the foetus, the number of accelerations and the ratio of reactivity in NST, but the two interventions did not have any superiority over each other. It is recommended to offer cake and juice to pregnant women before NST or have them watch a motivational video during NST, for having good NST results.Impact statement What is already known about the topic? The false-positive rates of the NST, which enables monitoring foetal movements and foetal heart rates, are high. These false-positive rates of the NST lead to many obstetric complications, in addition to increasing the rates of cesarean-section deliveries. Recent studies showed that there are methods and factors that increase foetal movements and shorten the application period of the NST. It was identified that food intake, music therapy, foetal vibroacoustic and halogen light stimulation before the NST increases foetal movements and shortens the application period of the NST. What this paper adds? In the study, it was found that watching motivational videos and consuming cake and juice increased the number of foetal movements, the number of accelerations and the rate of reactive NST results, but the two interventions did not have superiority over each other. What are the implications of these findings for clinical practice and/or further research? In order to increase reactive NST rates, it is recommended that pregnant women consume cake and fruit juice before the procedure and watch a motivational video during the NST procedure.Öğe The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome(Bmc, 2018) Tuncay, Gorkem; Karaer, Abdullah; Coskun, Ebru Inci; Baloglu, Demet; Tecellioglu, Ayse NihanBackground: The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. Methods: A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38-2.49 mIU/L and 2.50-4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L). Results: There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79-3.53), 1.08 (95% CI: 0.09-13.1), and 1.79 (95% CI: 0.77-4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit-administration rate) between the two groups. Conclusions: Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes.Öğe The impact of thyroid-stimulating hormone levels in euthyroid women onintrauterine insemination outcome(Bıomed central ltd, 236 grays ınn rd, floor 6, london wc1x 8hl, england, 2018) Tuncay, Gorkem; Karaer, Abdullah; Coskun, Ebru Inci; Baloglu, Demet; Tecellioglu, Ayse NihanBackground: The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. Methods: A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38-2.49 mIU/L and 2.50-4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L). Results: There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79-3.53), 1.08 (95% CI: 0.09-13.1), and 1.79 (95% CI: 0.77-4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit-administration rate) between the two groups. Conclusions: Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes.Öğe Metabolomic analysis of endometrial cancer by high-resolution magic angle spinning NMR spectroscopy(Springer Heidelberg, 2022) Duz, Senem Arda; Mumcu, Akin; Dogan, Berat; Yilmaz, Ercan; Coskun, Ebru Inci; Saridogan, Erdinc; Tuncay, GorkemPurpose To analyze endometrial metabolite profiles between patients with endometrial cancer and controls. Methods Seventeen (17) women with endometrium cancer and 18 controls were enrolled in this study. H-1 HR-MAS (High Resolution-Magic Angle Spinning) NMR (Nuclear Magnetic Resonance) spectroscopy data obtained from endometrial tissue samples of patients with endometrial cancer and control group were analyzed with bioinformatics methods. Results Principal component analysis (PCA) and the partial least squares discriminant analysis (PLS-DA) score plots obtained with the multivariate statistical analysis of pre-processed spectral data shows a separation between the samples from patients with endometrial cancer and controls. Analysis results suggest that the levels of lactate, glucose, o-phosphoethanolamine, choline, glycerophosphocholine, phosphocholine, leucine, isoleucine, valine, glutamate, glutamine, n-acetyltyrosine, methionine, taurine, alanine, aspartate and phenylalanine are increased in patients with endometrial cancer compared to the controls. Conclusion The metabolomics signature of patients with endometrial cancer is different from that of benign endometrial tissue.Öğe Metastasis of hepatocellular carcinoma in the ovary after liver transplantation out of Milan criteria(Lippincott Williams & Wilkins, 2016) Coskun, Ebru Inci; Kutluturk, Koray; Yilmaz, Ercan; Barut, Bora; Isik, Burak[Abstract Not Available]Öğe Multifocal low-grade endometrial stromal sarcoma arising from pre-existing endometriosis in a hysterectomised patient: a case report(Taylor & Francis Inc, 2019) Alan, Saadet; Yilmaz, Ercan; Tecellioglu, Fahriye; Akatli, Ayse Nur; Coskun, Ebru Inci; Gokce, Hasan[Abstract Not Available]Öğe Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer(Sage Publications Ltd, 2018) Yilmaz, Ercan; Gul, Mehmet; Melekoglu, Rauf; Coskun, Ebru Inci; Sahin, Nurhan; Gul, Semir; Bastemur, Ayse GulcinObjectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer. Methods The study participants were divided into patients with benign endometrial pathologies (Group 1, n=23), patients with endometrial hyperplasia (Group 2, n=21) and patients with endometrial cancer (Group 3, n=20). NEDD4L expression was detected by immunohistochemical staining and H scores were calculated to standardize staining intensity. Statistical analysis was performed using SPSS 16.0. Results NEDD4L expression levels according to H scores were significantly lower in patients diagnosed with endometrial cancer compared with those with benign endometrial pathologies. Conclusion NEDD4L is involved in maintaining cell stability, and reduced NEDD4L expression as a result of gene mutation may disrupt this balance in favor of tumorigenesis.Öğe RELATIONSHIP BETWEEN EPICARDIAL FAT THICKNESS AND PRESENCE AND SEVERITY OF PREECLAMPSIA(Lippincott Williams & Wilkins, 2016) Cakmak, Huseyin Altug; Abide, Cigdem Yayla; Cakmak, Burcu Dincgez; Coskun, Ebru Inci; Erturk, Mehmet; Keles, Ibrahim[Abstract Not Available]Öğe The relationships between blood pressure, blood glucose, and bone mineral density in postmenopausal Turkish women(Dove Medical Press Ltd, 2015) Cakmak, Huseyin Altug; Cakmak, Burcu Dincgez; Yumru, Ayse Ender; Aslan, Serkan; Enhos, Asim; Kalkan, Ali Kemal; Coskun, Ebru InciBackground: Hypertension, diabetes mellitus, and osteoporosis are important comorbidities commonly seen in postmenopausal women. The aim of the present study was to investigate the relationships between blood pressure, blood glucose, and bone mineral density (BMD) in postmenopausal Turkish women. Methods: In this cross-sectional study, 270 consecutive patients who were admitted to an outpatient clinic with vasomotor symptoms and/or at least 1 year of amenorrhea were included. The patients were categorized into three groups according to their blood pressure and metabolic status as follows: normotensive, hypertensive nondiabetics, and hypertensive diabetics. The T-and z-scores of the proximal femur and lumbar vertebrae were measured with the dual-energy X-ray absorptiometry method to assess the BMD of the study groups. Results: Lumbar vertebral T-scores (P<0.001), lumbar vertebral z-scores (P<0.003), and proximal femoral T-scores (P<0.001) were demonstrated to be significantly lower in the hypertensive diabetic group compared to the hypertensive nondiabetic and normotensive groups. Systolic blood pressure was significantly inversely correlated with lumbar vertebral T-scores (r=-0.382; P=0.001), lumbar vertebral z-scores (r=-0.290; P=0.001), and proximal femoral T-scores (r=-0.340; P=0.001). Moreover, diastolic blood pressure was significantly inversely correlated with lumbar vertebral T-scores (r=-0.318; P=0.001), lumbar vertebral z-scores (r=-0.340; P=0.001), and proximal femoral T-scores (r=-0.304; P=0.001). Hypertension (odds ratio [OR]: 2.541, 95% confidence interval [CI]: 1.46-3.48, P=0.003), diabetes mellitus (OR: 2.136, 95% CI: 1.254-3.678, P=0.006), and age (OR: 1.069, 95% CI: 1.007-1.163, P=0.022) were found to be significant independent predictors of osteopenia in a multivariate analysis, after adjusting for other risk parameters. Conclusion: The present study is the first to evaluate the relationships between blood pressure, blood glucose, and BMD in postmenopausal Turkish women. Moreover, both hypertension and diabetes were demonstrated as significant independent predictors of osteopenia in postmenopausal Turkish women. Clinicians should be aware of the high risk of developing osteopenia in diabetic hypertensive postmenopausal women.Öğe Renal cell carcinoma diagnosed during pregnancy: a case report and literature review(Sage Publications Ltd, 2018) Yilmaz, Ercan; Oguz, Fatih; Tuncay, Gorkem; Melekoglu, Rauf; Beytur, Ali; Coskun, Ebru Inci; Gunes, AliDiagnosing cancer during pregnancy is uncommon. Although pregnancies with concomitant malignancies have been reported, urological tumours are possibly the most rarely identified tumours during pregnancy. Renal cell carcinoma appears to be the most common urological malignancy during pregnancy. In this case report, we discuss successful management of a patient who was diagnosed with renal cell carcinoma during the antenatal period.Öğe Treatment of unruptured cornual pregnancies by local injections of methotrexate or potassium chloride under transvaginal ultrasonographic guidance(Professional Medical Publications, 2018) Tuncay, Gorkem; Karaer, Abdullah; Coskun, Ebru Inci; Melekoglu, RaufObjective: To demonstrate the outcome of intralesional management and show the safety of local treatment of cornual pregnancy. Methods: Eight patients were treated with local methotrexate or potassium chloride injection. All patients underwent transvaginal ultrasound examination and were diagnosed by the criteria defined by TimorTritsch. In the case of fetal heart beat observation, potassium chloride was injected; and in the case of no heart beat detection, methotrexate was used. A follicle aspiration needle was inserted directly into the gestational sac under transvaginal guidance. Results: Although it has been considered to be a risk factor, none of the patients in our study had previous ectopic pregnancy, history of infertility / in vitro fertilization, or cornual pregnancy. One of the patients had a medical history of abortion. In four cases, methotrexate was injected, and three patients received potassium chloride as a local treatment. None of the patients had any complication in the peri- or postoperative period. Conclusion: Using a local approach, the treatment agent can reach the area of the cornual pregnancy in high concentrations. Based on this case series, a local approach seems to be an effective and fertilitysparing method for treating unruptured cornual pregnancies.Öğe Vitronectin and prolactin levels of cervicovaginal irrigation liquid in preterm birth risk evaluation(2020) Coskun, Ebru Inci; Sezer, Salim; Dag, Ismail; Yilmaz, Ercan; Ayanoglu, Yavuz TahsinAim: The objective of this study is to determine the predictive role of cervical length, cervicovaginal irrigation liquid vitronectin and prolactin levels in preterm birth.Material and Methods: A total of 73 pregnant women between 24-34th gestational week were included and the study population was divided into two groups as: term birth group (n=54) and preterm birth(n=19). Birth weeks, weight and methods were noted. The irrigation fluid has been collected from posterior fornix and vitronectin levels are detected by Enzyme-linked-immunosorbent-assay method.Results: Vitronectin were higher in preterm group as compared to controls [90 (78-98) vs 16 (9-41) ng/ml, p0.001]. Positive predictive value for vitronectin was 78 %, negative predictive value was 100 % and accuracy ratio was 91.8%. The sensitivity of vitronectin was 100 %, specifity was 89 % with a cut-off value of 59 ng/mL. Area under curve for vitronectin was 0.96 which was compatible with ‘perfect’. When average prolactin levels have been found as 0.14 ng/mL in term and 2 ng/mL in preterm birth group, cervical length have been found as 34.5 and 24.2 mm respectively. Cut-off value for prolactin has been found as 0.088 ng/dL. Positive predictive value was 58.3 % for prolactin and 51.5 % for cervical length. Negative predictive value was 89.8% for prolactin and 95 % for cervical length. Vitronectin was strongly positively correlated with prolactin levels while it was negatively correlated with cervical length (r=0.691 and r=-0.348 respectively). Conclusion: Many trials have been done to make the most accurate prediction of preterm delivery risk. By this study, it makes us think about that vitronectin could be a valuable marker for preterm birth, and also could be independent from the gestational week.
